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https://ahro.austin.org.au/austinjspui/handle/1/33362
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DC Field | Value | Language |
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dc.contributor.author | Tan, Daniel J | - |
dc.contributor.author | Lodge, Caroline J | - |
dc.contributor.author | Walters, E Haydn | - |
dc.contributor.author | Lowe, Adrian J | - |
dc.contributor.author | Bui, Dinh S | - |
dc.contributor.author | Bowatte, Gayan | - |
dc.contributor.author | Pham, Jonathan | - |
dc.contributor.author | Erbas, Bircan | - |
dc.contributor.author | Hui, Jennie | - |
dc.contributor.author | Hamilton, Garun S | - |
dc.contributor.author | Thomas, Paul S | - |
dc.contributor.author | Hew, Mark | - |
dc.contributor.author | Washko, George | - |
dc.contributor.author | Wood-Baker, Richard | - |
dc.contributor.author | Abramson, Michael J | - |
dc.contributor.author | Perret, Jennifer L | - |
dc.contributor.author | Dharmage, Shyamali C | - |
dc.date.accessioned | 2023-07-19T02:15:46Z | - |
dc.date.available | 2023-07-19T02:15:46Z | - |
dc.date.issued | 2023-07-15 | - |
dc.identifier.citation | American Journal of Respiratory and Critical Care Medicine 2023-07-15; 208(2) | en_US |
dc.identifier.issn | 1535-4970 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/33362 | - |
dc.description.abstract | Rationale: Asthma is a heterogeneous condition, and longitudinal phenotyping may provide new insights into the origins and outcomes of the disease. Objectives: We aimed to characterize the longitudinal phenotypes of asthma between the first and sixth decades of life in a population-based cohort study. Methods: Respiratory questionnaires were collected at seven time points in the TAHS (Tasmanian Longitudinal Health Study) when participants were aged 7, 13, 18, 32, 43, 50, and 53 years. Current-asthma and ever-asthma status was determined at each time point, and group-based trajectory modeling was used to characterize distinct longitudinal phenotypes. Linear and logistic regression models were fitted to investigate associations of the longitudinal phenotypes with childhood factors and adult outcomes. Measurements and Main Results: Of 8,583 original participants, 1,506 had reported ever asthma. Five longitudinal asthma phenotypes were identified: early-onset adolescent-remitting (40%), early-onset adult-remitting (11%), early-onset persistent (9%), late-onset remitting (13%), and late-onset persistent (27%). All phenotypes were associated with chronic obstructive pulmonary disease at age 53 years, except for late-onset remitting asthma (odds ratios: early-onset adolescent-remitting, 2.00 [95% confidence interval (CI), 1.13-3.56]; early-onset adult-remitting, 3.61 [95% CI, 1.30-10.02]; early-onset persistent, 8.73 [95% CI, 4.10-18.55]; and late-onset persistent, 6.69 [95% CI, 3.81-11.73]). Late-onset persistent asthma was associated with the greatest comorbidity at age 53 years, with increased risk of mental health disorders and cardiovascular risk factors. Conclusions: Five longitudinal asthma phenotypes were identified between the first and sixth decades of life, including two novel remitting phenotypes. We found differential effects of these phenotypes on risk of chronic obstructive pulmonary disease and nonrespiratory comorbidities in middle age. | en_US |
dc.language.iso | eng | - |
dc.subject | asthma phenotypes | en_US |
dc.subject | chronic obstructive pulmonary disease | en_US |
dc.subject | comorbidities | en_US |
dc.subject | longitudinal phenotypes | en_US |
dc.subject | trajectories | en_US |
dc.title | Longitudinal Asthma Phenotypes from Childhood to Middle-Age: A Population-based Cohort Study. | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | American Journal of Respiratory and Critical Care Medicine | en_US |
dc.identifier.affiliation | Allergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia. | en_US |
dc.identifier.affiliation | School of Medicine, University of Tasmania, Hobart, Tasmania, Australia. | en_US |
dc.identifier.affiliation | Department of Basic Sciences, Faculty of Allied Health Sciences, University of Peradeniya, Peradeniya, Sri Lanka. | en_US |
dc.identifier.affiliation | Allergy, Asthma and Clinical Immunology, The Alfred Hospital, Melbourne, Victoria, Australia. | en_US |
dc.identifier.affiliation | School of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia. | en_US |
dc.identifier.affiliation | School of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia. | en_US |
dc.identifier.affiliation | Monash Lung, Sleep, Allergy & Immunology, Monash Health, Melbourne, Victoria, Australia.;School of Clinical Sciences and. | en_US |
dc.identifier.affiliation | Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia. | en_US |
dc.identifier.affiliation | Department of Basic Sciences, Faculty of Allied Health Sciences, University of Peradeniya, Peradeniya, Sri Lanka.;School of Public Health & Preventive Medicine, Monash University, Melbourne, Victoria, Australia. | en_US |
dc.identifier.affiliation | Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts; and. | en_US |
dc.identifier.affiliation | School of Medicine, University of Tasmania, Hobart, Tasmania, Australia. | en_US |
dc.identifier.affiliation | Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia. | en_US |
dc.identifier.affiliation | Institute for Breathing and Sleep | en_US |
dc.identifier.doi | 10.1164/rccm.202208-1569OC | en_US |
dc.type.content | Text | en_US |
dc.identifier.orcid | 0000-0003-3536-8756 | en_US |
dc.identifier.orcid | 0000-0002-4388-784X | en_US |
dc.identifier.orcid | 0000-0001-7034-0615 | en_US |
dc.identifier.pubmedid | 37209134 | - |
dc.description.volume | 208 | - |
dc.description.issue | 2 | - |
dc.description.startpage | 132 | - |
dc.description.endpage | 141 | - |
dc.subject.meshtermssecondary | Asthma/genetics | - |
local.name.researcher | Perret, Jennifer L | |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
Appears in Collections: | Journal articles |
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