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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33152
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dc.contributor.authorSingh, Parminder-
dc.contributor.authorGollapalli, Kishore-
dc.contributor.authorMangiola, Stefano-
dc.contributor.authorSchranner, Daniela-
dc.contributor.authorYusuf, Mohd Aslam-
dc.contributor.authorChamoli, Manish-
dc.contributor.authorShi, Sting L-
dc.contributor.authorLopes Bastos, Bruno-
dc.contributor.authorNair, Tripti-
dc.contributor.authorRiermeier, Annett-
dc.contributor.authorVayndorf, Elena M-
dc.contributor.authorWu, Judy Z-
dc.contributor.authorNilakhe, Aishwarya-
dc.contributor.authorNguyen, Christina Q-
dc.contributor.authorMuir, Michael-
dc.contributor.authorKiflezghi, Michael G-
dc.contributor.authorFoulger, Anna-
dc.contributor.authorJunker, Alex-
dc.contributor.authorDevine, Jack-
dc.contributor.authorSharan, Kunal-
dc.contributor.authorChinta, Shankar J-
dc.contributor.authorRajput, Swati-
dc.contributor.authorRane, Anand-
dc.contributor.authorBaumert, Philipp-
dc.contributor.authorSchönfelder, Martin-
dc.contributor.authorIavarone, Francescopaolo-
dc.contributor.authordi Lorenzo, Giorgia-
dc.contributor.authorKumari, Swati-
dc.contributor.authorGupta, Alka-
dc.contributor.authorSarkar, Rajesh-
dc.contributor.authorKhyriem, Costerwell-
dc.contributor.authorChawla, Amanpreet S-
dc.contributor.authorSharma, Ankur-
dc.contributor.authorSarper, Nazan-
dc.contributor.authorChattopadhyay, Naibedya-
dc.contributor.authorBiswal, Bichitra K-
dc.contributor.authorSettembre, Carmine-
dc.contributor.authorNagarajan, Perumal-
dc.contributor.authorTargoff, Kimara L-
dc.contributor.authorPicard, Martin-
dc.contributor.authorGupta, Sarika-
dc.contributor.authorVelagapudi, Vidya-
dc.contributor.authorPapenfuss, Anthony T-
dc.contributor.authorKaya, Alaattin-
dc.contributor.authorFerreira, Miguel Godinho-
dc.contributor.authorKennedy, Brian K-
dc.contributor.authorAndersen, Julie K-
dc.contributor.authorLithgow, Gordon J-
dc.contributor.authorAli, Abdullah Mahmood-
dc.contributor.authorMukhopadhyay, Arnab-
dc.contributor.authorPalotie, Aarno-
dc.contributor.authorKastenmüller, Gabi-
dc.contributor.authorKaeberlein, Matt-
dc.contributor.authorWackerhage, Henning-
dc.contributor.authorPal, Bhupinder-
dc.contributor.authorYadav, Vijay K-
dc.date2023-
dc.date.accessioned2023-06-22T06:48:53Z-
dc.date.available2023-06-22T06:48:53Z-
dc.date.issued2023-06-09-
dc.identifier.citationScience (New York, N.Y.) 2023-06-09; 380(6649)en_US
dc.identifier.issn1095-9203-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/33152-
dc.description.abstractAging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.en_US
dc.language.isoeng-
dc.titleTaurine deficiency as a driver of aging.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleScience (New York, N.Y.)en_US
dc.identifier.affiliationMetabolic Research Laboratories, National Institute of Immunology, New Delhi, India.en_US
dc.identifier.affiliationVagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.en_US
dc.identifier.affiliationOlivia Newton-John Cancer Research Instituteen_US
dc.identifier.affiliationExercise Biology Group, Technical University of Munich, Munich, Germany.;Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.en_US
dc.identifier.affiliationDepartment of Bioengineering, Integral University, Lucknow, India.en_US
dc.identifier.affiliationBuck Institute for Research on Aging, Novato, CA, USA.en_US
dc.identifier.affiliationVagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.en_US
dc.identifier.affiliationInstitute for Research on Cancer and Aging of Nice (IRCAN), Nice, France.en_US
dc.identifier.affiliationMolecular Aging Laboratory, National Institute of Immunology, New Delhi, India.en_US
dc.identifier.affiliationExercise Biology Group, Technical University of Munich, Munich, Germany.en_US
dc.identifier.affiliationSchool of Cancer Medicine, La Trobe University, Bundoora, VIC, Australia.en_US
dc.identifier.affiliationDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.en_US
dc.identifier.affiliationMetabolic Research Laboratories, National Institute of Immunology, New Delhi, India.en_US
dc.identifier.affiliationDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.en_US
dc.identifier.affiliationBuck Institute for Research on Aging, Novato, CA, USA.en_US
dc.identifier.affiliationDepartment of Neurology, Columbia University, New York, NY, USA.en_US
dc.identifier.affiliationMouse Genetics Project, Wellcome Sanger Institute, Cambridge, UK.en_US
dc.identifier.affiliationBuck Institute for Research on Aging, Novato, CA, USA.en_US
dc.identifier.affiliationDivision of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.en_US
dc.identifier.affiliationExercise Biology Group, Technical University of Munich, Munich, Germany.en_US
dc.identifier.affiliationTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.en_US
dc.identifier.affiliationMetabolic Research Laboratories, National Institute of Immunology, New Delhi, India.en_US
dc.identifier.affiliationHarry Perkins Institute of Medical Research, Perth, WA, Australia.;Curtin Medical School, Curtin University, Perth, WA, Australia.en_US
dc.identifier.affiliationImmunobiology Laboratory, National Institute of Immunology, New Delhi, India.;MRC-Protein Phosphorylation and Ubiquitination Unit, University of Dundee, Dundee, UK.en_US
dc.identifier.affiliationHarry Perkins Institute of Medical Research, Perth, WA, Australia.;Curtin Medical School, Curtin University, Perth, WA, Australia.en_US
dc.identifier.affiliationPediatrics and Pediatric Hematology, Kocaeli University Hospital, Kocaeli, Turkey.en_US
dc.identifier.affiliationDivision of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.en_US
dc.identifier.affiliationMetabolic Research Laboratories, National Institute of Immunology, New Delhi, India.en_US
dc.identifier.affiliationTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.;Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.en_US
dc.identifier.affiliationPrimate Research Facility, National Institute of Immunology, New Delhi, India.;Small Animal Research Facility, National Institute of Immunology, New Delhi, India.en_US
dc.identifier.affiliationDivision of Cardiology, Department of Pediatrics, Columbia University, New York, NY, USA.en_US
dc.identifier.affiliationDepartment of Neurology, Columbia University, New York, NY, USA.en_US
dc.identifier.affiliationMetabolic Research Laboratories, National Institute of Immunology, New Delhi, India.en_US
dc.identifier.affiliationInstitute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.en_US
dc.identifier.affiliationThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.;Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.en_US
dc.identifier.affiliationDepartment of Biology, Virginia Commonwealth University, Richmond, VA, USA.en_US
dc.identifier.affiliationInstitute for Research on Cancer and Aging of Nice (IRCAN), Nice, France.en_US
dc.identifier.affiliationHealthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.;Centre for Healthy Longevity, National University Health System, Singapore, Singapore.;Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.en_US
dc.identifier.affiliationBuck Institute for Research on Aging, Novato, CA, USA.en_US
dc.identifier.affiliationDepartment of Medicine, Columbia University Irving Medical Center, New York, NY, USA.en_US
dc.identifier.affiliationMolecular Aging Laboratory, National Institute of Immunology, New Delhi, India.en_US
dc.identifier.affiliationInstitute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.;Broad Institute of Harvard and MIT, Cambridge, MA, USA.;Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.en_US
dc.identifier.affiliationInstitute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.en_US
dc.identifier.affiliationDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.en_US
dc.identifier.affiliationExercise Biology Group, Technical University of Munich, Munich, Germany.en_US
dc.identifier.affiliationThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.en_US
dc.identifier.doi10.1126/science.abn9257en_US
dc.type.contentTexten_US
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dc.identifier.pubmedid37289866-
dc.description.volume380-
dc.description.issue6649-
dc.description.startpageeabn9257-
dc.subject.meshtermssecondaryAging/blood-
dc.subject.meshtermssecondaryAging/drug effects-
dc.subject.meshtermssecondaryAging/metabolism-
dc.subject.meshtermssecondaryLongevity/drug effects-
dc.subject.meshtermssecondaryLongevity/physiology-
dc.subject.meshtermssecondaryTaurine/blood-
dc.subject.meshtermssecondaryTaurine/deficiency-
dc.subject.meshtermssecondaryTaurine/pharmacology-
dc.subject.meshtermssecondaryDNA Damage/drug effects-
dc.subject.meshtermssecondaryTelomerase/metabolism-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
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