Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33042
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dc.contributor.authorMazzinari, Guido-
dc.contributor.authorZampieri, Fernando G-
dc.contributor.authorBall, Lorenzo-
dc.contributor.authorCampos, Niklas S-
dc.contributor.authorBluth, Thomas-
dc.contributor.authorHemmes, Sabrine N T-
dc.contributor.authorFerrando, Carlos-
dc.contributor.authorLibrero, Julian-
dc.contributor.authorSoro, Marina-
dc.contributor.authorPelosi, Paolo-
dc.contributor.authorGama de Abreu, Marcelo-
dc.contributor.authorSchultz, Marcus J-
dc.contributor.authorSerpa Neto, Ary-
dc.date2022-
dc.date.accessioned2023-06-07T02:47:25Z-
dc.date.available2023-06-07T02:47:25Z-
dc.date.issued2022-
dc.identifier.citationF1000Research 2022; 11en_US
dc.identifier.issn2046-1402-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/33042-
dc.description.abstractBackground: Using the frequentist approach, a recent meta-analysis of three randomized clinical trials in patients undergoing intraoperative ventilation during general anesthesia for major surgery failed to show the benefit of ventilation that uses high positive end-expiratory pressure with recruitment maneuvers when compared to ventilation that uses low positive end-expiratory pressure without recruitment maneuvers. Methods: We designed a protocol for a Bayesian analysis using the pooled dataset. The multilevel Bayesian logistic model will use the individual patient data. Prior distributions will be prespecified to represent a varying level of skepticism for the effect estimate. The primary endpoint will be a composite of postoperative pulmonary complications (PPC) within the first seven postoperative days, which reflects the primary endpoint of the original studies. We preset a range of practical equivalence to assess the futility of the intervention with an interval of odds ratio (OR) between 0.9 and 1.1 and assess how much of the 95% of highest density interval (HDI) falls between the region of practical equivalence. Ethics and dissemination: The used data derive from approved studies that were published in recent years. The findings of this current analysis will be reported in a new manuscript, drafted by the writing committee on behalf of the three research groups. All investigators listed in the original trials will serve as collaborative authors.en_US
dc.language.isoeng-
dc.subjectBayesian analysisen_US
dc.subjectMechanical ventilationen_US
dc.subjectPEEPen_US
dc.subjectintraoperative ventilationen_US
dc.subjectpostoperative pulmonary complicationsen_US
dc.subjectrecruitment maneuversen_US
dc.titleEffect of intraoperative PEEP with recruitment maneuvers on the occurrence of postoperative pulmonary complications during general anesthesia--protocol for Bayesian analysis of three randomized clinical trials of intraoperative ventilation.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleF1000Researchen_US
dc.identifier.affiliationAnesthesiology, Hospital Universitario y Politécnico la Fe, Valencia, Spain, 46026, Spain.;Perioperative Medicine, Instituto de Investigación Sanitaria la Fe, Valencia, Spain, 46026, Spain.en_US
dc.identifier.affiliationAcademic Research Organization, Albert Einstein Hospital, Sao Paulo, Brazil.en_US
dc.identifier.affiliationSurgical sciences and integrated diagnostics, University of Genoa, Genoa, Italy.;IRCCS Policlinico San Martino, Genoa, Italy.en_US
dc.identifier.affiliationCritical Care Medicine, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.;Cardio pulmonary department, Instituto do Coração, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidad de de Sao Paulo, Sao Paulo, Brazil.en_US
dc.identifier.affiliationPulmonary Engineergin group, Anesthesiology and intensive Care, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.en_US
dc.identifier.affiliationIntensive Care, Amsterdam University Medical Centers, location 'AMC', Amsterdam, The Netherlands.;Anesthesiology, Amsterdam University Medical Centers, location 'AMC', Amsterdam, The Netherlands.en_US
dc.identifier.affiliationAnesthesiology and Critical Care, Hospital Clinic de Barcelona, Institut D'investigació August Pi i Sunyer, Barcelona, Spain.;CIBER (Center of Biomedical Research in Respiratory Diseases, Instituto de Salud Carlos III, Madrid, Spain.en_US
dc.identifier.affiliationRed de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Pamplona, Spain.en_US
dc.identifier.affiliationINCLIVA Clinical Research Institute, Hospital Clinico Universitario de Valencia, Valencia, Spain.en_US
dc.identifier.affiliationSurgical sciences and integrated diagnostics, University of Genoa, Genoa, Italy.;IRCCS Policlinico San Martino, Genoa, Italy.en_US
dc.identifier.affiliationPulmonary Engineergin group, Anesthesiology and intensive Care, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.en_US
dc.identifier.affiliationIntensive Care, Amsterdam University Medical Centers, location 'AMC', Amsterdam, The Netherlands.;Mahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of tropical medicine, Mahidol University, Bangkok, Thailand.;Nuffield Department of Medicine, University of Oxford, Oxford, UK.en_US
dc.identifier.affiliationCritical Care Medicine, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.;Cardio pulmonary department, Instituto do Coração, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidad de de Sao Paulo, Sao Paulo, Brazil.;Intensive Care, Amsterdam University Medical Centers, location 'AMC', Amsterdam, The Netherlands.en_US
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre (ANZIC-RC), Monash University, Melbourne, Australia.en_US
dc.identifier.affiliationCriticalen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.identifier.doi10.12688/f1000research.125861.1en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-7377-331Xen_US
dc.identifier.pubmedid37234075-
dc.description.volume11-
dc.description.startpage1090-
dc.subject.meshtermssecondaryPositive-Pressure Respiration/adverse effects-
dc.subject.meshtermssecondaryPositive-Pressure Respiration/methods-
dc.subject.meshtermssecondaryPostoperative Complications/etiology-
dc.subject.meshtermssecondaryPostoperative Complications/epidemiology-
dc.subject.meshtermssecondaryAnesthesia, General/adverse effects-
dc.subject.meshtermssecondaryAnesthesia, General/methods-
local.name.researcherSerpa Neto, Ary
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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