1. AHRO : Austin Health Research Online
  2. Austin Health research
  3. Journal articles
Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/32935
Full metadata record
DC FieldValueLanguage
dc.contributor.authorChandrashekar, Chaitra-
dc.contributor.authorNishiuchi, Yuji-
dc.contributor.authorWhite, Barbara Fam-
dc.contributor.authorArsenakis, Yanni-
dc.contributor.authorLin, Feng-
dc.contributor.authorMcNeill, Samantha M-
dc.contributor.authorZhao, Peishen-
dc.contributor.authorvan Dun, Sam-
dc.contributor.authorKoijen, Anna-
dc.contributor.authorKajihara, Yasuhiro-
dc.contributor.authorWootten, Denise-
dc.contributor.authorvan den Bos, Leendert J-
dc.contributor.authorWade, John D-
dc.contributor.authorHossain, Mohammed Akhter-
dc.date2023-
dc.date.accessioned2023-06-07T02:25:18Z-
dc.date.available2023-06-07T02:25:18Z-
dc.date.issued2023-05-16-
dc.identifier.citationBioconjugate Chemistry 2023-05-16, 34(6)en_US
dc.identifier.issn1520-4812-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/32935-
dc.description.abstractExenatide was the first marketed GLP-1 receptor agonist for the treatment of type 2 diabetes. Modification to the chemical structure or the formulation has the potential to increase the stability of exenatide. We introduced human complex-type sialyloligosaccharide to exenatide at the native Asn28 position. The synthesis was achieved using both solid phase peptide synthesis (SPPS) and Omniligase-1-mediated chemoenzymatic ligation. The results demonstrate that glycosylation increases the proteolytic stability of exenatide while retaining its full biological activity.en_US
dc.language.isoeng-
dc.titleGlycosylation Improves the Proteolytic Stability of Exenatide.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleBioconjugate Chemistryen_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen_US
dc.identifier.affiliationGlyTech, Inc., 134 Chudoji Minamimachi, Kyoto 600-8813, Japanen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.identifier.affiliationMonash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia.en_US
dc.identifier.affiliationEnzyTag B.V., Daelderweg 9, 6361HK Nuth, The Netherlands.en_US
dc.identifier.affiliationGraduate School of Science, Osaka University, Toyonaka, Osaka 560-0043 Japan.en_US
dc.identifier.affiliationARC Centre for Cryo-Electron Microscopy of Membrane Proteins (CCeMMP), Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia.en_US
dc.identifier.affiliationSchool of Chemistry, Parkville, Victoria 3010, Australia.en_US
dc.identifier.affiliationDepartment of Biochemistry and Pharmacology, The University of Melbourne, Parkville, Victoria 3010, Australia.en_US
dc.identifier.affiliationGraduate School of Science, Tohoku University, Sendai, Miyagi 980-8579, Japan.en_US
dc.identifier.affiliationGeneral Medicineen_US
dc.identifier.doi10.1021/acs.bioconjchem.3c00120en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-0288-5952en_US
dc.identifier.orcid0000-0001-7662-5187en_US
dc.identifier.orcid0000-0001-5735-4924en_US
dc.identifier.orcid0000-0003-0185-0595en_US
dc.identifier.orcid0000-0002-6656-2394en_US
dc.identifier.orcid0000-0003-4563-1642en_US
dc.identifier.orcid0000-0002-1352-6568en_US
dc.identifier.orcid0000-0002-9961-0006en_US
dc.identifier.pubmedid37192432-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.languageiso639-1en-
item.cerifentitytypePublications-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

42
checked on Dec 19, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.