Proton Beam Radiation Therapy for Oropharyngeal Squamous Cell Carcinoma.

2023-04

Mendenhall, William M

Beitler, Jonathan J

Saba, Nabil F

Shaha, Ashok R

Nuyts, Sandra

Strojan, Primož

Bollen, Heleen

Cohen, Oded

Smee, Robert

Ng, Sweet Ping

Eisbruch, Avraham

Ng, Wai Tong

Kirwan, Jessica M

Ferlito, Alfio

cancer outcomes

head and neck cancer

oropharynx

particle therapy

Journal Article

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10.14338/IJPT-22-00030.1

To discuss the role of proton beam therapy (PBT) in the treatment of patients with oropharyngeal squamous cell carcinoma (OPSCC). A review of the pertinent literature. Proton beam therapy likely results in reduced acute and late toxicity as compared with intensity-modulated radiation therapy (IMRT). The extent of the reduced toxicity, which may be modest, depends on the endpoint and technical factors such as pencil beam versus passive scattered PBT and adaptive replanning. The disease control rates after PBT are likely similar to those after IMRT. Proton beam therapy is an attractive option to treat patients with OPSCC. Whether it becomes widely available depends on access.

link

International Journal of Particle Therapy 2023

International Journal of Particle Therapy

2331-5180