Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/32807
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dc.contributor.authorWei, Gavin-
dc.contributor.authorRanasinghe, Weranja-
dc.contributor.authorEvans, Melanie-
dc.contributor.authorBolton, Damien M-
dc.contributor.authorDodds, Lachlan-
dc.contributor.authorFrydenberg, Mark-
dc.contributor.authorKearns, Paul-
dc.contributor.authorLawrentschuk, Nathan-
dc.contributor.authorMurphy, Declan G-
dc.contributor.authorMillar, Jeremy-
dc.contributor.authorPapa, Nathan-
dc.date2023-
dc.date.accessioned2023-05-10T23:23:33Z-
dc.date.available2023-05-10T23:23:33Z-
dc.date.issued2023-04-26-
dc.identifier.citationBJU International 2023, 131 Suppl 4en_US
dc.identifier.issn1464-410X-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/32807-
dc.description.abstractTo assess changes in diagnosis prostate cancer (PCa) grade, biopsy and treatment approach over a decade (2011-2020) at a population level within a clinical quality cancer registry. Patients diagnosed by prostate biopsy between 2011 and 2020 were retrieved from the Victorian Prostate Cancer Outcomes Registry, a prospective, state-wide clinical quality registry in Australia. Distributions of each grade group (GG) proportion over time were modelled with restricted cubic splines, separately by biopsy technique, age group and subsequent treatment method. From 2011 to 2020, 24 308 men were diagnosed with PCa in the registry. The proportion of GG 1 disease declined from 36-23%, with commensurate rises in GG 2 (31-36%), GG 3 (14-17%) and GG 5 (9.3-14%) disease. This pattern was similar for men diagnosed by transrectal ultrasonography or transperineal biopsy. Patients aged <55 years had the largest absolute reduction in GG 1 PCa, from 56-35%, compared to patients aged 55-64 (41-31%), 65-74 (31-21%), and ≥75 years (12-10%). The proportion of prostatectomies performed for patients with GG 1 disease fell from 28% to 7.1% and, for primary radiation therapy, the proportion fell from 22% to 3.5%. From 2011 to 2020, there has been a substantial decrease in the proportion of GG 1 PCa diagnosed, particularly in younger men. The percentage of interventional management performed in GG 1 disease has fallen to very low levels. These results reflect the implementation of major changes to diagnostic and treatment guidelines and inform the future allocation of treatment methods.en_US
dc.language.isoeng-
dc.subjectGleason scoreen_US
dc.subjectbiopsyen_US
dc.subjectdiagnosisen_US
dc.subjectgradeen_US
dc.subjectgrade groupen_US
dc.subjectprostate canceren_US
dc.subjectregistryen_US
dc.subjecttrendsen_US
dc.titleDecade-long trends in prostate cancer biopsy grade groups and treatment within a population-based registry.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleBJU Internationalen_US
dc.identifier.affiliationDepartment of Urology, Monash Health, Monash University, Melbourne, Vic., Australia.en_US
dc.identifier.affiliationMonash University, Melbourne, Vic., Australia.;en_US
dc.identifier.affiliationSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Vic., Australia.en_US
dc.identifier.affiliationUrologyen_US
dc.identifier.affiliationDepartment of Urology, Ballarat Health Services, Ballarat, Vic., Australia.en_US
dc.identifier.affiliationDepartment of Surgery, Cabrini Health, Monash University, Melbourne, Vic., Australia.en_US
dc.identifier.affiliationDepartment of Urological Surgery, Barwon Health, Geelong, Vic., Australia.en_US
dc.identifier.affiliationDepartment of Urology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Vic., Australia.;Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.;EJ Whitten Prostate Cancer Research Centre at Epworth, Melbourne, Vic., Australia.en_US
dc.identifier.affiliationDivision of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.;Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Vic., Australia.en_US
dc.identifier.affiliationSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Vic., Australia.;Department of Radiation Oncology, Alfred Health, Melbourne, Vic., Australia.en_US
dc.identifier.affiliationLa Trobe University, Melbourne, Vic., Australia.en_US
dc.identifier.doi10.1111/bju.15980en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-5168-6346en_US
dc.identifier.orcid0000-0002-4006-0388en_US
dc.identifier.orcid0000-0001-8553-5618en_US
dc.identifier.orcid0000-0002-7500-5899en_US
dc.identifier.pubmedid37099558-
local.name.researcherBolton, Damien M
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
crisitem.author.deptSurgery (University of Melbourne)-
crisitem.author.deptUrology-
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