Trubiano, Jason; Leung, Vivian K; Chu, Man Y; Worth, Leon J; Slavin, Monica A; Thursky, Karin A

doi:10.1186/s13756-015-0063-6

Author(s)

Trubiano, Jason

Leung, Vivian K

Chu, Man Y

Worth, Leon J

Slavin, Monica A

Thursky, Karin A

Publication Date

2015

Abstract

Antibiotic allergy labels are associated with sub-optimal prescribing patterns and poorer clinical outcomes in non-cancer populations, but the effect of labelling on antimicrobial usage in patients with cancer is unknown. A retrospective review of hospitalized patients admitted to the Peter MacCallum Cancer Centre (2010-2012) identified 23 % of cancer patients (n = 198) with an antimicrobial allergy label (AA). Comparison of those with an antimicrobial allergy label to those without demonstrated increased antibiotic use per admission (3 vs. 2, p = 0.01), increased fluoroquinolone use (11 % vs. 6 %, p < 0.05), increased antibiotic course duration (15 vs. 13 days, p = 0.09), higher readmission rates (53 % vs. 28 %, p < 0.001) and poorer concordance with prescribing guidelines (47 % vs. 91 %, p < 0.001). Patients in the AA group on multivariate analysis had a higher number of antibiotics employed, longer duration of antibiotic therapy and higher rate of readmission. Antimicrobial usage, including the use of restricted antibiotics, is higher in patients with cancer. Antibiotic de-labelling strategies in cancer patients must be evaluated to aid antimicrobial stewardship initiatives.

Citation

Antimicrobial Resistance and Infection Control 2015; 4

Jornal Title

Antimicrobial Resistance and Infection Control

OrcId

#PLACEHOLDER_PARENT_METADATA_VALUE#

Link

https://ahro.austin.org.au/austinjspui/handle/1/32691

Subject

Antibiotic allergy

Antimicrobial resistance

Cancer

Stewardship

Title

The impact of antimicrobial allergy labels on antimicrobial usage in cancer patients

Type of document

Journal Article

Austin Health

The impact of antimicrobial allergy labels on antimicrobial usage in cancer patients

Files:

Author(s)	Trubiano, Jason Leung, Vivian K Chu, Man Y Worth, Leon J Slavin, Monica A Thursky, Karin A
Publication Date	2015
Abstract	Antibiotic allergy labels are associated with sub-optimal prescribing patterns and poorer clinical outcomes in non-cancer populations, but the effect of labelling on antimicrobial usage in patients with cancer is unknown. A retrospective review of hospitalized patients admitted to the Peter MacCallum Cancer Centre (2010-2012) identified 23 % of cancer patients (n = 198) with an antimicrobial allergy label (AA). Comparison of those with an antimicrobial allergy label to those without demonstrated increased antibiotic use per admission (3 vs. 2, p = 0.01), increased fluoroquinolone use (11 % vs. 6 %, p < 0.05), increased antibiotic course duration (15 vs. 13 days, p = 0.09), higher readmission rates (53 % vs. 28 %, p < 0.001) and poorer concordance with prescribing guidelines (47 % vs. 91 %, p < 0.001). Patients in the AA group on multivariate analysis had a higher number of antibiotics employed, longer duration of antibiotic therapy and higher rate of readmission. Antimicrobial usage, including the use of restricted antibiotics, is higher in patients with cancer. Antibiotic de-labelling strategies in cancer patients must be evaluated to aid antimicrobial stewardship initiatives.
Citation	Antimicrobial Resistance and Infection Control 2015; 4
Jornal Title	Antimicrobial Resistance and Infection Control
OrcId	#PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE#
Link	https://ahro.austin.org.au/austinjspui/handle/1/32691
Subject	Antibiotic allergy Antimicrobial resistance Cancer Stewardship
Title	The impact of antimicrobial allergy labels on antimicrobial usage in cancer patients
Type of document	Journal Article