Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorFrentiu, Angela A-
dc.contributor.authorMao, Kevin-
dc.contributor.authorCaruana, Carla Borg-
dc.contributor.authorRaveendran, Dev-
dc.contributor.authorPerry, Luke A-
dc.contributor.authorPenny-Dimri, Jahan C-
dc.contributor.authorRamson, Dhruvesh M-
dc.contributor.authorSegal, Reny-
dc.contributor.authorBellomo, Rinaldo-
dc.contributor.authorSmith, Julian A-
dc.contributor.authorLiu, Zhengyang-
dc.identifier.citationJournal of Cardiothoracic and Vascular Anesthesia 2023en_US
dc.description.abstractRed cell distribution width (RDW) is a routinely available biomarker of likely erythropoietic dysfunction, which may be associated with adverse outcomes after cardiac surgery. This systematic review and meta-analysis aimed to clarify the prognostic value of RDW in patients undergoing cardiac surgery. The authors searched MEDLINE, Embase, and the Cochrane Library from inception to May 10, 2022 for studies investigating the association between elevated RDW (as defined by the authors of included studies) and adverse outcomes after cardiac surgery. Herein, the authors extracted maximally adjusted hazard ratios (HRs) and odds ratios (ORs) with associated CIs, and pooled them using random-effects inverse- variance modeling. The authors explored interstudy heterogeneity using metaregression. The authors included 26 studies involving 48,092 patients who had undergone cardiac surgery. Elevated preoperative RDW was associated with long-term mortality (pooled HR 1.63, 95% CI 1.05-2.52), short-term mortality (pooled OR 2.16, 95% CI 1.21-3.87), acute kidney injury (AKI; pooled OR 1.30, 95% CI 1.19-1.41) and postoperative atrial fibrillation (POAF; pooled OR 1.44, 95% CI 1.05-1.96). Some studies suggested a significant association between preoperative RDW elevation and neurologic complications; however, their number was insufficient for meta-analysis. The postoperative RDW levels were less consistently reported and could not be meta-analyzed. In conclusion, the authors found that elevated preoperative RDW was associated with increased short- and long-term mortality, POAF, and AKI after cardiac surgery. Further research is needed to investigate its role in the risk stratification of patients undergoing cardiac surgery.en_US
dc.subjectRed cell distribution width (RDW)en_US
dc.subjectAcute kidney injuryen_US
dc.subjectCardiac surgeryen_US
dc.subjectPost-operative atrial fibrillationen_US
dc.titleThe Prognostic Significance of Red Cell Distribution Width in Cardiac Surgery: A Systematic Review and Meta-Analysis.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Cardiothoracic and Vascular Anesthesiaen_US
dc.identifier.affiliationDepartment of Cardiothoracic Surgery, Monash Health, Clayton, Australia.en_US
dc.identifier.affiliationDepartment of Surgery (School of Clinical Sciences at Monash Health), Monash University, Clayton, Australia.en_US
dc.identifier.affiliationDepartment of Critical Care, Melbourne Medical School, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Australiaen_US
dc.identifier.affiliationDepartment of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, Australia.en_US
dc.identifier.affiliationIntensive Careen_US
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Melbourne, Australiaen_US
dc.identifier.affiliationMonash University School and Public Health and Preventive Medicine, Monash University, Clayton, Australiaen_US
dc.identifier.affiliationData Analytics Research and Evaluation (DARE) Centreen_US
dc.identifier.pubmedid36635145-, Rinaldo
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.cerifentitytypePublications- Care- Analytics Research and Evaluation (DARE) Centre-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

checked on Sep 26, 2023

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.