Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/31649
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dc.contributor.authorHarraka, P-
dc.contributor.authorWightman, Tony-
dc.contributor.authorAkom, Sarah-
dc.contributor.authorSandhu, Kieran-
dc.contributor.authorColville, Deb-
dc.contributor.authorCatran, Andrew-
dc.contributor.authorLangsford, David-
dc.contributor.authorPianta, Timothy-
dc.contributor.authorBarit, David-
dc.contributor.authorIerino, Frank-
dc.contributor.authorSkene, Alison-
dc.contributor.authorMack, Heather-
dc.contributor.authorSavige, Judy-
dc.date2022-
dc.date.accessioned2023-01-12T01:48:46Z-
dc.date.available2023-01-12T01:48:46Z-
dc.date.issued2022-10-31-
dc.identifier.citationScientific Reports 2022en_US
dc.identifier.issn2045-2322-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/31649-
dc.description.abstractDrusen are retinal deposits comprising cell debris, immune material and complement that are characteristic of macular degeneration but also found in glomerulonephritis. This was a pilot cross-sectional study to determine how often drusen occurred in IgA glomerulonephritis and their clinical significance. Study participants underwent non-mydriatic retinal photography, and their deidentified retinal images were examined for drusen by two trained graders, who compared central drusen counts, counts ≥ 10 and drusen size with those of matched controls. The cohort comprised 122 individuals with IgA glomerulonephritis including 89 males (73%), 49 individuals (40%) of East Asian or Southern European ancestry, with an overall median age of 54 years (34-64), and median disease duration of 9 years (4-17). Thirty-nine (33%) had an eGFR < 60 ml/min/1.73 m2 and 72 had previously reached kidney failure (61%). Overall mean drusen counts were higher in IgA glomerulonephritis (9 ± 27) than controls (2 ± 7, p < 0.001). Central counts ≥ 10 were also more common (OR = 3.31 (1.42-7.73, p = 0.006), and were associated with longer disease duration (p = 0.03) but not kidney failure (p = 0.31). Larger drusen were associated with more mesangial IgA staining (p = 0.004). Increased drusen counts were also present in IgA glomerulonephritis secondary to Crohn's disease but not with Henoch-Schonlein purpura. The finding of retinal drusen in IgA glomerulonephritis is consistent with complement activation and represents a model for better understanding glomerular immune deposition and a supporting argument for treatment with anti-complement therapies.en_US
dc.language.isoeng-
dc.subjectglomerulonephritisen_US
dc.subjectretinal drusenen_US
dc.titleIncreased retinal drusen in IgA glomerulonephritis are further evidence for complement activation in disease pathogenesis.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleScientific Reportsen_US
dc.identifier.affiliationDepartment of Medicine, Northern Health, The University of Melbourne, Parkville, VIC, 3050, Australia.en_US
dc.identifier.affiliationNephrologyen_US
dc.identifier.affiliationPathologyen_US
dc.identifier.affiliationThe University of Melbourne Department of Ophthalmology, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC 3002, Australia.en_US
dc.identifier.doi10.1038/s41598-022-21386-yen_US
dc.type.contentTexten_US
dc.identifier.pubmedid36316518-
dc.description.volume12-
dc.description.issue1-
dc.description.startpage18301-
dc.subject.meshtermssecondaryRetinal Drusen/etiology-
dc.subject.meshtermssecondaryGlomerulonephritis, IGA/complications-
dc.subject.meshtermssecondaryComplement Activation/physiology-
dc.subject.meshtermssecondaryGlomerulonephritis/complications-
local.name.researcherSkene, Alison
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
crisitem.author.deptPathology-
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