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Title: A companion to the preclinical common data elements for proteomics, lipidomics and metabolomics data in rodent epilepsy models. A Report of the TASK3-WG4 Omics Working Group of the ILAE/AES Joint Translational Task Force.
Austin Authors: Bindila, Laura;Eid, Tore;Mills, James D;Hildebrand, Michael S ;Brennan, Gary P;Masino, Susan A;Whittemore, Vicky;Perucca, Piero ;Reid, Christopher A;Patel, Manisha;Wang, Kevin K;van Vliet, Erwin A
Affiliation: Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia
Clinical Lipidomics Unit, Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany..
Epilepsy Research Centre
Bladin-Berkovic Comprehensive Epilepsy Program, Austin Health, Heidelberg, Victoria, Australia
Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia
Department of Neurology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia
Department of Neurology, Alfred Health, Melbourne, Victoria, Australia
The Florey Institute of Neuroscience and Mental Health
Department of Laboratory Medicine, Yale School of Medicine, New Haven, Connecticut, USA..
Amsterdam UMC, University of Amsterdam, Dept (Neuro)Pathology, Amsterdam Neuroscience, Amsterdam, the Netherlands..
UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland.. FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland..
Neuroscience Program and Psychology Department, Life Sciences Center, Trinity College, Hartford, Connecticut, USA..
Division of Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA..
Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA..
Program for Neurotrauma, Neuroproteomics & Biomarker Research (NNBR), Department of Emergency Medicine, Psychiatry and Neuroscience, University of Florida, Gainesville, Florida, USA.. Brain Rehabilitation Research Center, Malcom Randall VA Medical Center, North Florida/South Georgia Veterans Health System, Gainesville, Florida, USA..
Issue Date: 18-Oct-2022
Date: 2022
Publication information: Epilepsia Open 2022
Abstract: The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. This is the second in a two-part series of omics papers, with the other including genomics, transcriptomics and epigenomics. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy research related methods. We have generated CDE tables with key parameters and case report forms (CRFs) containing the essential contents of the study protocols for proteomics, lipidomics and metabolomics of samples from rodent models and people with epilepsy. We discuss the important elements that need to be considered for the proteomics, lipidomics and metabolomics methodologies, providing a rationale for the parameters that should be documented.
DOI: 10.1002/epi4.12662
ORCID: 0000-0001-9217-6393
Journal: Epilepsia Open
PubMed URL: 36259125
Type: Journal Article
Subjects: case report form
omic data processing
Appears in Collections:Journal articles

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