Bindila, Laura

Eid, Tore

Mills, James D

Hildebrand, Michael S

Brennan, Gary P

Masino, Susan A

Whittemore, Vicky

Perucca, Piero

Reid, Christopher A

Patel, Manisha

Wang, Kevin K

van Vliet, Erwin A

2022-10-18

The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. This is the second in a two-part series of omics papers, with the other including genomics, transcriptomics and epigenomics. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy research related methods. We have generated CDE tables with key parameters and case report forms (CRFs) containing the essential contents of the study protocols for proteomics, lipidomics and metabolomics of samples from rodent models and people with epilepsy. We discuss the important elements that need to be considered for the proteomics, lipidomics and metabolomics methodologies, providing a rationale for the parameters that should be documented.

Epilepsia Open 2022

Epilepsia Open

0000-0001-9217-6393

0000-0003-4237-4900

0000-0002-7855-7066

0000-0002-1457-8028

0000-0001-5747-3202

https://ahro.austin.org.au/austinjspui/handle/1/31089

case report form

lipidome

metabolome

omic data processing

preclinical

proteome

rodent

A companion to the preclinical common data elements for proteomics, lipidomics and metabolomics data in rodent epilepsy models. A Report of the TASK3-WG4 Omics Working Group of the ILAE/AES Joint Translational Task Force.

Journal Article