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dc.contributor.authorYeow, Marcus-
dc.contributor.authorZhao, Joseph J-
dc.contributor.authorFong, Khi Yung-
dc.contributor.authorWong, Joel-
dc.contributor.authorTan, Alvin Yong Hui-
dc.contributor.authorKam, Juinn Huar-
dc.contributor.authorNikfarjam, Mehrdad-
dc.contributor.authorGoh, Brian K P-
dc.contributor.authorKabir, Tousif-
dc.identifier.citationWorld Journal of Surgery 2022; 46(11): 2778-2787en
dc.description.abstractAn updated systematic review and meta-analysis was conducted to compare radiofrequency ablation (RFA) versus repeat hepatectomy (RH) for patients with recurrent hepatocellular carcinoma (rHCC) after a previous liver resection. PubMed, EMBASE, and Cochrane databases were searched from inception to October 2021 for randomized controlled trials and propensity-score matched studies. Individual participant survival data of disease-free survival (DFS) and overall survival (OS) were extracted and reconstructed followed by one-stage and two-stage meta-analysis. Secondary outcomes were major complications and length of hospital stay (LOHS). A total of seven studies (1317 patients) were analysed. In both one-stage and two-stage meta-analysis, there was no significant difference in OS between the RFA and RH cohorts (Hazard Ratio (HR) 1.15, 95% CI 0.98-1.36, P = 0.094 and HR 1.12, 95% CI 0.77-1.64, P = 0.474 respectively), while the RFA group had a higher hazard rate of disease recurrence compared to the RH group (HR 1.30, 95% CI 1.13-1.50, P < 0.001 and HR 1.31, 95% CI 1.09-1.57, P = 0.013, respectively). RFA was associated with fewer major complications and shorter LOHS versus RH (Odds Ratio 0.34, 95% CI 0.15-0.76, P = 0.009 and Weighted Mean Difference - 4.78, 95% CI - 6.30 to - 3.26, P < 0.001, respectively). RH may be associated with superior DFS for rHCC, at the expense of higher morbidity rate and longer LOHS. However, OS is comparable between both modalities. As such, these techniques may be utilized as complementary strategies depending on individual patient and disease factors. Large-scale, randomized, prospective studies are required to corroborate these findings.en
dc.titleRadiofrequency Ablation Versus Repeat Hepatectomy for Recurrent Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.en
dc.typeJournal Articleen
dc.identifier.journaltitleWorld Journal of Surgeryen
dc.identifier.affiliationDepartment of General Surgery, Sengkang General Hospital, Singapore, Singapore.. Department of Hepatopancreatobiliary Surgery, Austin Hospital, 145 Studley Rd, Heidelberg, Melbourne, VIC, 3084, Australiaen
dc.identifier.affiliationHepatopancreatobiliary Surgeryen
dc.identifier.affiliationYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore..en
dc.identifier.affiliationDepartment of General Surgery, Sengkang General Hospital, Singapore, Singapore..en
dc.identifier.pubmedid35989371-, Tousif
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristype (University of Melbourne)- Surgery-
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