Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30903
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dc.contributor.authorSewell, Kelsey R-
dc.contributor.authorRainey-Smith, Stephanie R-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorPeiffer, Jeremiah-
dc.contributor.authorSohrabi, Hamid R-
dc.contributor.authorTaddei, Kevin-
dc.contributor.authorAmes, David-
dc.contributor.authorDoré, Vincent-
dc.contributor.authorMaruff, Paul-
dc.contributor.authorLaws, Simon M-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorMartins, Ralph N-
dc.contributor.authorErickson, Kirk I-
dc.contributor.authorBrown, Belinda M-
dc.date2022-
dc.date.accessioned2022-09-20T06:51:58Z-
dc.date.available2022-09-20T06:51:58Z-
dc.date.issued2022-09-11-
dc.identifier.citationBehavioural Brain Research 2022; 437: 114108en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/30903-
dc.description.abstractLifestyle factors such as physical activity and optimal sleep are associated with better cognition and lower levels of Alzheimer's disease (AD) biomarkers, including brain beta-amyloid (Aβ) burden. We utilised cross-sectional data from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study to determine whether self-reported physical activity (measured via the International Physical Activity Questionnaire) moderates the relationship between self-reported sleep (measured via the Pittsburgh Sleep Quality Index), cognition, and brain Aβ. Participants were 349 community-dwelling cognitively normal older adults (75.3 ± 5.7 years), all of whom underwent comprehensive cognitive assessment. Data from a subset of participants (n = 201) were used for analyses with brain Aβ burden (measured by positron emission tomography) as the outcome. Physical activity moderated the relationship between sleep duration and episodic memory (β = -0.10, SE =0.03, p = .005), and sleep efficiency and episodic memory (β = -0.09, SE =0.04, p = .011), such that greater amounts of physical activity mitigated the impact of suboptimal sleep duration and efficiency on episodic memory. Physical activity also moderated the relationship between sleep duration and brain Aβ (β = -0.13, SE =0.06, p = .031), and overall sleep quality and brain Aβ (β = 0.13, SE =0.06, p = .027). Our findings suggest that physical activity may play an important role in the relationship between sleep and cognitive function, and brain Aβ.en_US
dc.language.isoeng-
dc.subjectBeta-amyloiden_US
dc.subjectCognitive functionen_US
dc.subjectOlder adultsen_US
dc.subjectPhysical activityen_US
dc.subjectSleepen_US
dc.titleThe interaction between physical activity and sleep on cognitive function and brain beta-amyloid in older adults.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleBehavioural Brain Researchen_US
dc.identifier.affiliationDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USAen_US
dc.identifier.affiliationSchool of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australiaen_US
dc.identifier.affiliationDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USAen_US
dc.identifier.affiliationCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australiaen_US
dc.identifier.affiliationDepartment of Molecular Imaging & Therapy, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australiaen_US
dc.identifier.affiliationAustralian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australiaen_US
dc.identifier.affiliationSchool of Psychological Science, University of Western Australia, Perth, Western Australia, Australiaen_US
dc.identifier.affiliationFlorey Institute of Neuroscience and Mental Healthen_US
dc.identifier.affiliationDepartment of Biomedical Sciences, Macquarie University, Sydney, New South Wales, Australiaen_US
dc.identifier.affiliationNational Ageing Research Institute, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationUniversity of Melbourne Academic Unit for Psychiatry of Old Age, St George's Hospital, Kew, Victoria, Australiaen_US
dc.identifier.affiliationCogstate Ltd, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationCentre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australiaen_US
dc.identifier.affiliationCollaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australiaen_US
dc.identifier.doi10.1016/j.bbr.2022.114108en_US
dc.type.contentTexten_US
dc.identifier.pubmedid36100010-
local.name.researcherDoré, Vincent
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptMolecular Imaging and Therapy-
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