Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30896
Title: Hepatitis B Virus Flares following Nucleot(s)ide Analogue Cessation Are Associated with Activation of TLR Signalling Pathways.
Austin Authors: Hall, Samuel Al;Burns, Gareth S;Mooney, Benjamin J;Millen, Rosemary;Morris, Rachel;Vogrin, Sara;Sundararajan, Vijaya;Ratnam, Dilip;Levy, Miriam T;Lubel, John S;Nicoll, Amanda J;Strasser, Simone I;Sievert, William;Desmond, Paul V;Ngu, Meng C;Angus, Peter W ;Sinclair, Marie ;Meredith, Christopher;Matthews, Gail;Revill, Peter A;Jackson, Kathy;Littlejohn, Margaret;Bowden, Scott;Locarnini, Stephen A;Thompson, Alexander J;Visvanathan, Kumar
Affiliation: Department of infectious Disease, St Vincent's Hospital Sydney  Sydney  Australia
Gastroenterology and Hepatology
University of Melbourne  Melbourne, Australia
Gastroenterology Department of Bankstown-Lidcombe Hospital  Sydney, Australia
Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, The Doherty Institute  Melbourne, Australia
Gastroenterology Department of St Vincent's Hospital Melbourne  Melbourne, Australia
Department of Infectious Disease and Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia
Gastroenterology Department of St Vincent's Hospital Melbourne (Melbourne, Australia
Department of Infectious Disease and Immunology Research Centre, St Vincent's Hospital, (Melbourne, Australia
The Department of Public Health, La Trobe University  Melbourne, Australia
Gastroenterology & Hepatology Unit, Monash Health  Melbourne, Australia
Gastroenterology Department of Liverpool Hospital  Sydney, Australia
Department of Gastroenterology, Alfred Health  Melbourne, Australia
Central Clinical School, Monash University, The Alfred Centre  Melbourne, Australia
Gastroenterology Department of Eastern Health  Melbourne, Australia
AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital  Sydney, Australia
University of Sydney  Sydney, Australia
Monash University  Melbourne, Australia
Gastroenterology Department of Concord Repatriation General Hospital  Sydney, Australia
Issue Date: 15-Sep-2022
Date: 2022
Publication information: The Journal of Infectious Diseases 2022
Abstract: We evaluated the patterns of peripheral TLR signalling activity and the expression of TLRs and NK cell activation in a cohort of patients experiencing severe hepatitis flares after stopping NA therapy. Samples were collected longitudinally from CHB patients enrolled in a prospective study of NA discontinuation. Patients experiencing hepatitis flares were compared to patients with normal ALT. PBMC were stimulated with TLR ligands and cytokine secretion in the cell culture supernatant measured. Expression of TLR2/4, NKG2D, NKp46 and TREM-1 on monocytes, NK and NK-T cells was measured. 17 patients with severe reactivation hepatitis flares were compared to 12 non-flare patients. Hepatitis flares were associated with increased activity of TLR 2-8 and TLR 9 signalling in PBMC at the time of peak flare compared to baseline. Hepatitis flares were also associated with upregulation of TLR2, and TREM-1 receptor expression on NK. There were no differences at baseline between flare patients and non-flare patients. Hepatitis flares off NA therapy have a significant innate inflammatory response with upregulation of TLR signalling on peripheral monocytes and TLR-2 and TREM-1 expression on NK cells. This implicates the innate immune system in the immunopathogenesis of hepatitis B flares.
URI: https://ahro.austin.org.au/austinjspui/handle/1/30896
DOI: 10.1093/infdis/jiac375
ORCID: 0000-0001-7158-585X
Journal: The Journal of Infectious Diseases
PubMed URL: 36108079
Type: Journal Article
Subjects: Cessation
Entecavir
Flare
Hepatitis B Virus
Tenofovir
Appears in Collections:Journal articles

Show full item record

Page view(s)

58
checked on Dec 12, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.