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DC Field | Value | Language |
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dc.contributor.author | Hu, Raymond T C | - |
dc.contributor.author | Royse, Alistair G | - |
dc.contributor.author | Royse, Colin | - |
dc.contributor.author | Scott, David A | - |
dc.contributor.author | Bowyer, Andrea | - |
dc.contributor.author | Boggett, Stuart | - |
dc.contributor.author | Summers, Peter | - |
dc.contributor.author | Mazer, Cyril David | - |
dc.date | 2022 | - |
dc.date.accessioned | 2022-09-20T06:46:05Z | - |
dc.date.available | 2022-09-20T06:46:05Z | - |
dc.date.issued | 2022-09-06 | - |
dc.identifier.citation | Transfusion 2022; 62(10): 1973-1983 | en_US |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/30870 | - |
dc.description.abstract | Transfusion Requirements in Cardiac Surgery III (TRICS III), a multi-center randomized controlled trial, demonstrated clinical non-inferiority for restrictive versus liberal RBC transfusion for patients undergoing cardiac surgery. However, it is uncertain if transfusion strategy affects long-term health-related quality of life (HRQOL). In this planned sub-study of Australian patients in TRICS III, we sought to determine the non-inferiority of restrictive versus liberal transfusion strategy on long-term HRQOL and to describe clinical outcomes 24 months postoperatively. The restrictive strategy involved transfusing RBCs when hemoglobin was <7.5 g/dl; the transfusion triggers in the liberal group were: <9.5 g/L intraoperatively, <9.5 g/L in intensive care, or <8.5 g/dl on the ward. HRQOL assessments were performed using the 36-item short form survey version 2 (SF-36v2). Primary outcome was non-inferiority of summary measures of SF-36v2 at 12 months, (non-inferiority margin: -0.25 effect size; restrictive minus liberal scores). Secondary outcomes included non-inferiority of HRQOL at 18 and 24 months. Six hundred seventeen Australian patients received allocated randomization; HRQOL data were available for 208/311 in restrictive and 217/306 in liberal group. After multiple imputation, non-inferiority of restrictive transfusion at 12 months was not demonstrated for HRQOL, and the estimates were directionally in favor of liberal transfusion. Non-inferiority also could not be concluded at 18 and 24 months. Sensitivity analyses supported these results. There were no differences in quality-adjusted life years or composite clinical outcomes up to 24 months after surgery. The non-inferiority of a restrictive compared to a liberal transfusion strategy was not established for long-term HRQOL in this dataset. | en_US |
dc.language.iso | eng | - |
dc.subject | RBCs | en_US |
dc.subject | cardiac surgery | en_US |
dc.subject | hemoglobin | en_US |
dc.subject | quality of life | en_US |
dc.subject | randomized controlled trial | en_US |
dc.subject | transfusion medicine | en_US |
dc.title | Health-related quality of life after restrictive versus liberal RBC transfusion for cardiac surgery: Sub-study from a randomized clinical trial. | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | Transfusion | en_US |
dc.identifier.affiliation | Outcomes Research Consortium, The Cleveland Clinic, Cleveland, Ohio, USA | en_US |
dc.identifier.affiliation | Statistical Consulting Centre, University of Melbourne, Parkville, Victoria, Australia | en_US |
dc.identifier.affiliation | Melbourne Disability Institute, University of Melbourne, Parkville, Victoria, Australia | en_US |
dc.identifier.affiliation | Centre for Health Analytics, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia | en_US |
dc.identifier.affiliation | Department of Anaesthesia and Acute Pain Medicine, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia | en_US |
dc.identifier.affiliation | Department of Surgery, University of Melbourne, Parkville, Victoria, Australia | en_US |
dc.identifier.affiliation | Anaesthesia | en_US |
dc.identifier.affiliation | Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, Victoria, Australia | en_US |
dc.identifier.affiliation | Department of Anaesthesia, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.. | en_US |
dc.identifier.doi | 10.1111/trf.17084 | en_US |
dc.type.content | Text | en_US |
dc.identifier.orcid | 0000-0002-0169-0600 | en_US |
dc.identifier.pubmedid | 36066319 | - |
local.name.researcher | Hu, Raymond T C | |
item.grantfulltext | none | - |
item.openairetype | Journal Article | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Anaesthesia | - |
Appears in Collections: | Journal articles |
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