Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30870
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dc.contributor.authorHu, Raymond T C-
dc.contributor.authorRoyse, Alistair G-
dc.contributor.authorRoyse, Colin-
dc.contributor.authorScott, David A-
dc.contributor.authorBowyer, Andrea-
dc.contributor.authorBoggett, Stuart-
dc.contributor.authorSummers, Peter-
dc.contributor.authorMazer, Cyril David-
dc.date2022-
dc.date.accessioned2022-09-20T06:46:05Z-
dc.date.available2022-09-20T06:46:05Z-
dc.date.issued2022-09-06-
dc.identifier.citationTransfusion 2022; 62(10): 1973-1983en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/30870-
dc.description.abstractTransfusion Requirements in Cardiac Surgery III (TRICS III), a multi-center randomized controlled trial, demonstrated clinical non-inferiority for restrictive versus liberal RBC transfusion for patients undergoing cardiac surgery. However, it is uncertain if transfusion strategy affects long-term health-related quality of life (HRQOL). In this planned sub-study of Australian patients in TRICS III, we sought to determine the non-inferiority of restrictive versus liberal transfusion strategy on long-term HRQOL and to describe clinical outcomes 24 months postoperatively. The restrictive strategy involved transfusing RBCs when hemoglobin was <7.5 g/dl; the transfusion triggers in the liberal group were: <9.5 g/L intraoperatively, <9.5 g/L in intensive care, or <8.5 g/dl on the ward. HRQOL assessments were performed using the 36-item short form survey version 2 (SF-36v2). Primary outcome was non-inferiority of summary measures of SF-36v2 at 12 months, (non-inferiority margin: -0.25 effect size; restrictive minus liberal scores). Secondary outcomes included non-inferiority of HRQOL at 18 and 24 months. Six hundred seventeen Australian patients received allocated randomization; HRQOL data were available for 208/311 in restrictive and 217/306 in liberal group. After multiple imputation, non-inferiority of restrictive transfusion at 12 months was not demonstrated for HRQOL, and the estimates were directionally in favor of liberal transfusion. Non-inferiority also could not be concluded at 18 and 24 months. Sensitivity analyses supported these results. There were no differences in quality-adjusted life years or composite clinical outcomes up to 24 months after surgery. The non-inferiority of a restrictive compared to a liberal transfusion strategy was not established for long-term HRQOL in this dataset.en_US
dc.language.isoeng-
dc.subjectRBCsen_US
dc.subjectcardiac surgeryen_US
dc.subjecthemoglobinen_US
dc.subjectquality of lifeen_US
dc.subjectrandomized controlled trialen_US
dc.subjecttransfusion medicineen_US
dc.titleHealth-related quality of life after restrictive versus liberal RBC transfusion for cardiac surgery: Sub-study from a randomized clinical trial.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleTransfusionen_US
dc.identifier.affiliationOutcomes Research Consortium, The Cleveland Clinic, Cleveland, Ohio, USAen_US
dc.identifier.affiliationStatistical Consulting Centre, University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationMelbourne Disability Institute, University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationCentre for Health Analytics, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Anaesthesia and Acute Pain Medicine, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationAnaesthesiaen_US
dc.identifier.affiliationDepartment of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Anaesthesia, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada..en_US
dc.identifier.doi10.1111/trf.17084en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-0169-0600en_US
dc.identifier.pubmedid36066319-
local.name.researcherHu, Raymond T C
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptAnaesthesia-
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