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https://ahro.austin.org.au/austinjspui/handle/1/30830
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Carà, Gianmarco A | - |
dc.contributor.author | Pasin, Laura | - |
dc.contributor.author | Alborino, Ettore | - |
dc.contributor.author | Zarbock, Alexander | - |
dc.contributor.author | Bellomo, Rinaldo | - |
dc.contributor.author | Landoni, Giovanni | - |
dc.date | 2022 | - |
dc.date.accessioned | 2022-09-06T06:51:17Z | - |
dc.date.available | 2022-09-06T06:51:17Z | - |
dc.date.issued | 2022-07-22 | - |
dc.identifier.citation | Journal of Cardiothoracic and Vascular Anesthesia 2022; 36(12) | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/30830 | - |
dc.description.abstract | The renin-angiotensin-aldosterone system (RAAS), whose major vasopressor effector is angiotensin II (ATII), has multiple activities and regulates sodium-water homeostasis and fluid and blood pressure homeostasis. RAAS plays a crucial role in cardiocirculatory shock because it counteracts hypotension and hypovolemia by activating different physiologic responses. Based on the encouraging results of the ATHOS-3 trial, the US Food and Drug Administration and the European Medicines Agency approved the use of ATII for catecholamine-resistant vasodilatory shock. More recently, ATII was used for the compassionate treatment of critically ill patients with COVID-19. Beyond its vasopressor properties, ATII was hypothesized to have antiviral activity because it induces internalization and degradation of angiotensin-converting enzyme 2 receptors used by SARS-Cov-2 to infect cells. Overall, the use of ATII in patients with COVID-19 showed promising results because its administration was associated with the achievement and maintenance of target mean arterial pressure, increased PaO2/FIO2 ratio, and decreased FIO2. The aim of this narrative review is to summarize the available knowledge on the use of ATII in patients with COVID-19. | en |
dc.language.iso | eng | - |
dc.subject | COVID-19 | en |
dc.subject | angiotensin-II | en |
dc.subject | shock | en |
dc.subject | vasopressor | en |
dc.title | Angiotensin II - A Brief Review and Role in Severe SARS-COV-2 Sepsis. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Journal of Cardiothoracic and Vascular Anesthesia | en |
dc.identifier.affiliation | Department of Critical Care, School of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.. | en |
dc.identifier.affiliation | Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.. | en |
dc.identifier.affiliation | Data Analytics Research and Evaluation (DARE) Centre | en |
dc.identifier.affiliation | Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.. | en |
dc.identifier.affiliation | Intensive Care | en |
dc.identifier.affiliation | Department of Anesthesia and Intensive Care, Azienda Ospedale-Università di Padova, Padova, Italy.. | en |
dc.identifier.affiliation | Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.. | en |
dc.identifier.affiliation | School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.. | en |
dc.identifier.pubmeduri | https://pubmed.ncbi.nlm.nih.gov/35995637/ | en |
dc.identifier.doi | 10.1053/j.jvca.2022.07.022 | en |
dc.type.content | Text | en |
dc.identifier.orcid | 0000-0002-1650-8939 | en |
dc.identifier.pubmedid | 35995637 | - |
local.name.researcher | Bellomo, Rinaldo | |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Data Analytics Research and Evaluation (DARE) Centre | - |
Appears in Collections: | Journal articles |
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