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https://ahro.austin.org.au/austinjspui/handle/1/30742
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Schumann, J L | - |
dc.contributor.author | Syrjanen, R | - |
dc.contributor.author | Alford, K | - |
dc.contributor.author | Mashetty, S | - |
dc.contributor.author | Castle, J W | - |
dc.contributor.author | Rotella, Joe Anthony | - |
dc.contributor.author | Maplesden, J | - |
dc.contributor.author | Greene, Shaun L | - |
dc.date | 2022 | - |
dc.date.accessioned | 2022-08-25T05:17:36Z | - |
dc.date.available | 2022-08-25T05:17:36Z | - |
dc.date.issued | 2022-08-19 | - |
dc.identifier.citation | Journal of Analytical Toxicology 2022; 47(1):e6-e9 | - |
dc.identifier.issn | 1945-2403 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/30742 | - |
dc.description.abstract | Benzimidazole synthetic opioids are highly potent μ-opioid receptor agonists with heroin-like effects, including dose-dependent respiratory depression and a high risk of abuse and toxicity. Benzimidazoles were first detected in 2019 in Europe and Canada, with analytical confirmation of etodesnitazene, protonitazene and butonitazene in 2021. We report the first detections of these compounds in Australia, in two patients presenting with drug toxicity to Emergency Departments in the state of Victoria. Case 1 was a female in her 20s who rectally administered etodesnitazene and was found unconscious with a respiratory depression and hypotension. Case 2 was a female in her 30s who presented to the ED in a sedated state after taking a formulation of protonitazene which also contained butonitazene, in addition to methylamphetamine. She responded positively to naloxone. Novel synthetic opioids were used with prior experience of the formulations purchased, however the unpredictability of their effects was demonstrated by the acute toxicity experienced with this occasion of use. Toxicosurveillance of Emergency Department presentations with analytical confirmation of drugs is crucial in identifying emerging drugs in the community and informing harm reduction strategies. | - |
dc.language.iso | eng | - |
dc.subject | drug toxicity | - |
dc.subject | early warning system | - |
dc.subject | naloxone | - |
dc.subject | novel psychoactive substance | - |
dc.subject | novel synthetic opioid | - |
dc.title | Intoxications in an Australian Emergency Department Involving 'Nitazene' Benzylbenzimidazole Synthetic Opioids (Etodesnitazene, Butonitazene and Protonitazene). | - |
dc.type | Journal Article | - |
dc.identifier.journaltitle | Journal of Analytical Toxicology | - |
dc.identifier.affiliation | Victorian Poisons Information Centre | - |
dc.identifier.affiliation | Emergency | - |
dc.identifier.affiliation | Department of Emergency Medicine, Northern Hospital, Melbourne, Australia | - |
dc.identifier.affiliation | Monash Addiction Research Centre, Melbourne, Australia | - |
dc.identifier.affiliation | Department of Critical Care, University of Melbourne | - |
dc.identifier.affiliation | Department of Emergency Medicine, Dandenong Hospital, Melbourne, Australia | - |
dc.identifier.affiliation | Department of Emergency Medicine, St Vincent's Hospital, Melbourne, Australia | - |
dc.identifier.affiliation | Department of Forensic Medicine, Monash University | - |
dc.identifier.affiliation | Victorian Institute of Forensic Medicine, Melbourne, Australia | - |
dc.identifier.pubmeduri | https://pubmed.ncbi.nlm.nih.gov/35983900/ | - |
dc.identifier.doi | 10.1093/jat/bkac062 | - |
dc.type.content | Text | - |
dc.identifier.orcid | 0000-0002-7423-2467 | - |
dc.identifier.orcid | 0000-0003-2068-8757 | - |
dc.identifier.pubmedid | 35983900 | - |
dc.description.volume | 47 | - |
dc.description.issue | 1 | - |
dc.description.startpage | e6 | - |
dc.description.endpage | e9 | - |
local.name.researcher | Greene, Shaun L | |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Emergency | - |
crisitem.author.dept | Toxicology | - |
Appears in Collections: | Journal articles |
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