Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30635
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dc.contributor.authorYanai, Henit-
dc.contributor.authorKagramanova, Anna-
dc.contributor.authorKnyazev, Oleg-
dc.contributor.authorSabino, João-
dc.contributor.authorHaenen, Shana-
dc.contributor.authorMantzaris, Gerassimos J-
dc.contributor.authorMountaki, Katerina-
dc.contributor.authorArmuzzi, Alessandro-
dc.contributor.authorPugliese, Daniela-
dc.contributor.authorFurfaro, Federica-
dc.contributor.authorFiorino, Gionata-
dc.contributor.authorDrobne, David-
dc.contributor.authorKurent, Tina-
dc.contributor.authorYassin, Sharif-
dc.contributor.authorMaharshak, Nitsan-
dc.contributor.authorCastiglione, Fabiana-
dc.contributor.authorde Sire, Roberto-
dc.contributor.authorNardone, Olga Maria-
dc.contributor.authorFarkas, Klaudia-
dc.contributor.authorMolnar, Tamas-
dc.contributor.authorKrznaric, Zeljko-
dc.contributor.authorBrinar, Marko-
dc.contributor.authorChashkova, Elena-
dc.contributor.authorLivne Margolin, Moran-
dc.contributor.authorKopylov, Uri-
dc.contributor.authorBezzio, Cristina-
dc.contributor.authorShitrit, Ariella Bar-Gil-
dc.contributor.authorLukas, Milan-
dc.contributor.authorChaparro, María-
dc.contributor.authorTruyens, Marie-
dc.contributor.authorNancey, Stéphane-
dc.contributor.authorLobaton, Triana-
dc.contributor.authorGisbert, Javier P-
dc.contributor.authorSaibeni, Simone-
dc.contributor.authorBacsúr, Péter-
dc.contributor.authorBossuyt, Peter-
dc.contributor.authorSchulberg, Julien-
dc.contributor.authorHoentjen, Frank-
dc.contributor.authorViganò, Chiara-
dc.contributor.authorPalermo, Andrea-
dc.contributor.authorTorres, Joana-
dc.contributor.authorRevés, Joana-
dc.contributor.authorKarmiris, Konstantinos-
dc.contributor.authorVelegraki, Magdalini-
dc.contributor.authorSavarino, Edoardo-
dc.contributor.authorMarkopoulos, Panagiotis-
dc.contributor.authorTsironi, Eftychia-
dc.contributor.authorEllul, Pierre-
dc.contributor.authorSuárez, Cristina Calviño-
dc.contributor.authorWeisshof, Roni-
dc.contributor.authorBen-Hur, Dana-
dc.contributor.authorNaftali, Timna-
dc.contributor.authorEriksson, Carl-
dc.contributor.authorKoutroubakis, Ioannis E-
dc.contributor.authorFoteinogiannopoulou, Kalliopi-
dc.contributor.authorLimdi, Jimmy K-
dc.contributor.authorLiu, Eleanor-
dc.contributor.authorSurís, Gerard-
dc.contributor.authorCalabrese, Emma-
dc.contributor.authorZorzi, Francesca-
dc.contributor.authorFilip, Rafał-
dc.contributor.authorRibaldone, Davide Giuseppe-
dc.contributor.authorSnir, Yifat-
dc.contributor.authorGoren, Idan-
dc.contributor.authorBanai-Eran, Hagar-
dc.contributor.authorBroytman, Yelena-
dc.contributor.authorBarak, Hadar Amir-
dc.contributor.authorAvni-Biron, Irit-
dc.contributor.authorOllech, Jacob E-
dc.contributor.authorDotan, Iris-
dc.contributor.authorAharoni Golan, Maya-
dc.date2022-
dc.date.accessioned2022-08-02T06:42:38Z-
dc.date.available2022-08-02T06:42:38Z-
dc.date.issued2022-07-27-
dc.identifier.citationJournal of Crohn's & colitis 2022; online first: 27 Julyen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/30635-
dc.description.abstractEndoscopic-post-operative-recurrence (ePOR) in Crohn's disease (CD) after ileocecal resection (ICR) is a major concern. We aimed to evaluate the effectiveness of early prophylaxis with biologics and to compare anti-TNF therapy to vedolizumab (VDZ) and ustekinumab (UST) in a real-world setting. A retrospective multicenter study of CD-adults after curative ICR on early prophylaxis. ePOR was defined as a Rutgeerts score [RS]≥i2 or colonic-segmental-SES-CD≥6. Multivariable logistic regression was used to evaluate risk factors, and inverse probability treatment weighting (IPTW) was applied to compare the effectiveness between agents. Included 297 patients (53.9% males, age at diagnosis 24y[19-32], age at ICR-34y[26-43], 18.5% smokers, 27.6% biologic-naïve, 65.7% anti-TNF experienced, 28.6%≥2 biologics, and 17.2% previous surgery). Overall, 224, 39 and 34 patients received anti-TNF, VDZ or UST, respectively. Patients treated with VDZ and UST were more biologic experienced with higher rates of previous surgery. ePOR rates within 1-year were: 41.8%. ePOR rates by treatment groups: anti-TNF 40.2%, VDZ 33% and UST 61.8%. Risk factors for ePOR at 1-year: past-infliximab (adj.OR=1.73[95%CI:1.01-2.97]), past-adalimumab (adj.OR=2.32[95% CI:1.35-4.01) and surgical aspects. After IPTW, the risk of ePOR within 1-year of VDZ vs. anti-TNF or UST vs. anti-TNF was comparable (OR=0.55[95%CI:0.25-1.19], OR=1.86[95%CI:0.79-4.38]), respectively. Prevention of ePOR within 1-year after surgery was successful in ~60% of patients. Patients treated with VDZ or UST consisted of a more refractory group. After controlling for confounders, no differences in ePOR risk were seen between anti-TNF prophylaxis and other groups.en
dc.language.isoeng
dc.subjectBiologicsen
dc.subjectCrohn’s diseaseen
dc.subjectPost-operative recurrenceen
dc.titleEndoscopic Postoperative Recurrence In Crohn's Disease After Curative Ileocecal Resection With Early Prophylaxis By Anti-Tnf, Vedolizumab Or Ustekinumab: A Real-World Multicenter European Study.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Crohn's & colitisen
dc.identifier.affiliationDivision of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel..en
dc.identifier.affiliationSackler Faculty of Medicine, Tel Aviv University, Israel..en
dc.identifier.affiliationMoscow Clinical Scientific Centre named after. A.S. Loginov, Moscow, Russia..en
dc.identifier.affiliationState Scientific Centre of Coloproctology named after A.N. Ryzhyh, Moscow, Russian Federation..en
dc.identifier.affiliationResearch Institute of Health Organization and Medical Management, Moscow, Russian Federation..en
dc.identifier.affiliationDepartment of Gastroenterology, University Hospitals of Leuven, Leuven, Belgium..en
dc.identifier.affiliationDepartment of Gastroenterology, GHA "Evaggelismos-Ophthalmiatreion Athinon-Polykliniki", Athens, Greece..en
dc.identifier.affiliationIBDUnit, IRCCS Humanitas Research Hospital, Department of Biomedical Sciences Humanitas University, Milan, Italy..en
dc.identifier.affiliationCEMAD, IBD UNIT, Unità Operativa Complessa di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy..en
dc.identifier.affiliationIBD Center, Humanitas Research Hospital-IRCCS, Milan, Italy..en
dc.identifier.affiliationGastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, Milan, Italy..en
dc.identifier.affiliationDepartment of Internal Medicine, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia..en
dc.identifier.affiliationDepartment of Gastroenterology, University Medical Centre Ljubljana, Ljubljana, Slovenia..en
dc.identifier.affiliationDepartment of Gastroenterology and Liver Diseases, Tel Aviv Medical Center, Tel Aviv, Israel..en
dc.identifier.affiliationDepartment of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy..en
dc.identifier.affiliationDepartment of Public Health, University of Naples Federico II, Naples Italy..en
dc.identifier.affiliationDepartment of Medicine, University of Szeged, Szeged, Hungary..en
dc.identifier.affiliationDepartment of Gastroenterology, Hepatology and Nutrition, University Hospital Centre, Zagreb, Croatia..en
dc.identifier.affiliationIrkutsk Scientific Center of Surgery and Traumatology, Russia..en
dc.identifier.affiliationDepartment of Gastroenterology, Sheba medical center, Tel Hashomer, Israel..en
dc.identifier.affiliationGastroenterology Unit, Rho Hospital, ASST Rhodense, Rho (MI), Italy..en
dc.identifier.affiliationDigestive Diseases Institute, Shaare Zedek Medical Center, Jerusalem, Israel..en
dc.identifier.affiliationFaculty of Medicine, Hebrew University, Jerusalem, Israel..en
dc.identifier.affiliationClinical and Research Centre for Inflammatory Bowel Disease, ISCARE Clinical Centre, Prague, Czech Republic..en
dc.identifier.affiliationInstitute of Medical Biochemistry and Laboratory Medicine, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic..en
dc.identifier.affiliationDepartment of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS- Princesa), Universidad Autónoma de Madrid (UAM), Spain..en
dc.identifier.affiliationCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain..en
dc.identifier.affiliationIBD unit, Department of Gastroenterology, University Hospital Ghent, Ghent, Belgium..en
dc.identifier.affiliationDepartment of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium..en
dc.identifier.affiliationDepartment of Gastroenterology, Lyon-Sud hospital, Hospices Civils de Lyon, Lyon and INSERM U1111, CIRI, Lyon, France..en
dc.identifier.affiliationImelda GI clinical research center, department of gastroenterology, Imelda General Hospital, Bonheiden, Belgium..en
dc.identifier.affiliationDepartment of Gastroenterology, St Vincent's Hospital, Melbourne, VIC, Australia..en
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Melbourne, VIC, Australia..en
dc.identifier.affiliationGastroenterology and Hepatologyen
dc.identifier.affiliationInflammatory Bowel Disease Center, Department of Gastroenterology, Radboud University Medical Center, Nijmegen, The Netherlands and Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Canada..en
dc.identifier.affiliationDivision of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy..en
dc.identifier.affiliationEuropean Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy..en
dc.identifier.affiliationDivision of Gastroenterology, Hospital da Luz Lisboa, Portugal..en
dc.identifier.affiliationDivision of Gastroenterology, Hospital Beatriz Ângelo, Loures, Lisbon, Portugal..en
dc.identifier.affiliationDepartment of Gastroenterology, Venizeleio General Hospital, Heraklion, Crete, Greece..en
dc.identifier.affiliationDepartment of Surgical Oncological & Gastroenterological Sciences (DiSCOG), Gastroenterology Unit, Padua University, Padua, Italy..en
dc.identifier.affiliationDepartment of Gastroenterology, Metaxa Memorial General Hospital, Piraeus, Greece..en
dc.identifier.affiliationDivision of Gastroenterology Mater Dei Hospital, Msida, Malta..en
dc.identifier.affiliationDepartment of Gastroenterology and Hepatology, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain..en
dc.identifier.affiliationDepartment of Gastroenterology, Rambam Health Care Campus, Haifa, Israel..en
dc.identifier.affiliationRappaport Faculty of Medicine, The Technion - Israel Institute of Technology, Haifa, Israel..en
dc.identifier.affiliationInstitute of gastroenterology, Meir Hospital Sapir Medical Center, Kfar Saba, Israel..en
dc.identifier.affiliationDepartment of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden..en
dc.identifier.affiliationGastroenterology Department, University Hospital of Heraklion, Crete, Greece..en
dc.identifier.affiliationDepartment of Gastroenterology, The Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Sciences, University of Manchester, Manchester, UK..en
dc.identifier.affiliationGastroenterology Department, Hospital de Bellvitge and IDIBELL, L'Hospitalet, Spain..en
dc.identifier.affiliationGastroenterology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Italy..en
dc.identifier.affiliationDepartment of Gastroenterology with IBD Unit, Clinical Hospital No. 2, Rzeszów, Poland..en
dc.identifier.affiliationDepartment of Medical Sciences, University of Turin, Turin, Italy..en
dc.identifier.affiliationDepartment of Gastroenterology and Hepatology, Kaplan Medical Center, Rehovot, Israel..en
dc.identifier.affiliationFaculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel..en
dc.identifier.affiliationConcord Medical Center, Clalit Health Services, Bnei Brak, Israel..en
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/35895074/en
dc.identifier.doi10.1093/ecco-jcc/jjac100en
dc.type.contentTexten
dc.identifier.orcid0000-0001-5623-2968en
dc.identifier.orcid0000-0003-2734-675Xen
dc.identifier.orcid0000-0002-6448-2649en
dc.identifier.orcid0000-0001-5677-2534en
dc.identifier.orcid0000-0003-4027-7365en
dc.identifier.orcid0000-0003-2895-5821en
dc.identifier.orcid0000-0003-4128-0718en
dc.identifier.orcid0000-0002-1046-383Xen
dc.identifier.orcid0000-0003-0554-5256en
dc.identifier.orcid0000-0002-9421-3087en
dc.identifier.orcid0000-0002-2162-2840en
dc.identifier.orcid0000-0002-0257-6535en
dc.identifier.pubmedid35895074
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
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