Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30624
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSmith, Drew-
dc.contributor.authorJoon, Daryl Lim-
dc.contributor.authorKnight, Kellie-
dc.contributor.authorSim, Jenny-
dc.contributor.authorSchneider, Michal-
dc.contributor.authorLau, Eddie-
dc.contributor.authorForoudi, Farshad-
dc.contributor.authorKhoo, Vincent-
dc.date2022-
dc.date.accessioned2022-08-02T06:42:30Z-
dc.date.available2022-08-02T06:42:30Z-
dc.date.issued2022-07-30-
dc.identifier.citationJournal of Medical Radiation Sciences 2022; 69(4)en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/30624-
dc.description.abstractAnal cancer (AC) is 18 F-FDG-PET avid and has been used to evaluate treatment response several months after chemoradiotherapy. This pilot study aimed to assess the utility of semi-automated contouring methods and quantitative measures of treatment response using 18 F-FDG-PET imaging at the early time point of 1-month post-chemoradiotherapy. Eleven patients with AC referred for chemoradiotherapy were prospectively enrolled into this study, with 10 meeting eligibility requirements. 18 F-FDG-PET imaging was obtained pre-chemoradiotherapy (TP1), and then 1-month (TP2), 3-6 months (TP3) and 9-12 months (TP4) post-chemoradiotherapy. Manual and semi-automated (Threshold) contouring methods were used to define the primary tumour on all 18 F-FDG-PET images. Resultant contours from each method were interrogated using quantitative measures, including volume, response index (RI), total lesion glycolysis (TLG), SUVmax , SUVmedian and SUVmean . Response was assessed quantitatively as reductions in these measures and also qualitatively against established criteria. Nine patients were qualitatively classified as complete metabolic responders at TP2 and all 10 at TP3. All quantitative measures demonstrated significant (P < 0.05) reductions at TP2 for both Manual and Threshold methods. All reduced further at TP3 and again at TP4 for Threshold methods. TLG showed the highest reduction at all post-chemoradiotherapy time points and classified the most responders for each method at each time point. All patients are recurrence-free at minimum 4-year follow-up. Based on our small sample size, semi-automated methods of disease definition using 18 F-FDG-PET imaging are feasible and appear to facilitate quantitative response classification of AC as early as 1-month post-chemoradiotherapy. Early identification of treatment response may potentially improve disease management.en
dc.language.isoeng-
dc.subjectAnal canalen
dc.subjectcanceren
dc.subjectpositron emission tomographyen
dc.subjectradiotherapyen
dc.subjectresponseen
dc.titleA pilot study investigating the role of 18 F-FDG-PET in the early identification of chemoradiotherapy response in anal cancer.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of medical radiation sciencesen
dc.identifier.affiliationDepartment of Clinical Oncology, The Royal Marsden NHS Foundation Trust, London, UK..en
dc.identifier.affiliationOlivia Newton-John Cancer Wellness and Research Centreen
dc.identifier.affiliationDepartment of Medical Imaging and Radiation Sciences, Monash University, Clayton, Victoria, Australia..en
dc.identifier.affiliationMolecular Imaging and Therapyen
dc.identifier.affiliationDepartment of Radiology, University of Melbourne, Melbourne, Victoria, Australia..en
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Melbourne, Victoria, Australia..en
dc.identifier.affiliationRadiation Oncologyen
dc.identifier.affiliationRadiologyen
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/35906833/en
dc.identifier.doi10.1002/jmrs.611en
dc.type.contentTexten
dc.identifier.orcid0000-0002-7378-8586en
dc.identifier.orcid0000-0002-1947-9694en
dc.identifier.orcid0000-0003-4767-0776en
dc.identifier.orcid0000-0002-0756-3848en
dc.identifier.orcid0000-0002-5521-3455en
dc.identifier.orcid0000-0002-1261-7775en
dc.identifier.orcid0000-0001-8387-0965en
dc.identifier.orcid0000-0002-0763-6832en
dc.identifier.pubmedid35906833-
local.name.researcherForoudi, Farshad
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptRadiology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
crisitem.author.deptRadiation Oncology-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

32
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.