Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30589
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dc.contributor.authorVajda, Frank-
dc.contributor.authorO'Brien, Terence-
dc.contributor.authorGraham, Janet-
dc.contributor.authorHitchcock, Alison-
dc.contributor.authorPerucca, Piero-
dc.contributor.authorLander, Cecilie-
dc.contributor.authorEadie, Mervyn-
dc.date2022-
dc.date.accessioned2022-07-27T23:26:32Z-
dc.date.available2022-07-27T23:26:32Z-
dc.date.issued2022-07-18-
dc.identifier.citationEpilepsy & Behavior: E&B 2022-09; 134: 108848en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/30589-
dc.description.abstractTo utilize data from the Australian Register of Antiepileptic Drugs in Pregnancy (APR) to determine the hazard of fetal malformation in the subsequent pregnancy or pregnancies in women with epilepsy following a pregnancy associated with a fetal malformation, and to identify factors relevant to the hazard. There was a 7.4% initial pregnancy fetal malformation rate. The subsequent pregnancy malformation rate was 4.2% if there was no initial pregnancy malformation, but 21.2% if there was an initial pregnancy malformation (O.R. = 6.1448, 95% C.I. 2.3396, 16.1386). For pregnancies where antiseizure medication (ASM) therapy was unchanged between pregnancies (N = 196), the initial pregnancy malformation rate was 10.2%, but 30.0% in the subsequent pregnancy if there was a malformation in the initial pregnancy, and 2.35% if there was none (O.R. = 17.7857, 95% C.I. 4.4847, 70.5361). A cohort comprising 24% of the women with fetal malformations in their initial pregnancies seemed to be intrinsically vulnerable to fetal malformation during successive pregnancies: when their seizure disorder type had been recorded all had genetic generalized epilepsies, compared with a 45.8% generalized epilepsy rate in women with initial but not subsequent pregnancy malformations (P = 0.0121). If fetal malformation had occurred in an initial ASM-treated pregnancy there was a significantly increased hazard of fetal malformation in the subsequent pregnancy, particularly if the woman involved had a genetic generalized epilepsy.en
dc.language.isoeng-
dc.subjectAntiseizure medicationen
dc.subjectEpilepsyen
dc.subjectFetal malformationen
dc.subjectSuccessive pregnanciesen
dc.titleFetal malformations in successive pregnancies in Australian women with epilepsy.en
dc.typeJournal Articleen
dc.identifier.journaltitleEpilepsy & behavior : E&Ben
dc.identifier.affiliationDepartments of Medicine and Neurosciences, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria 3050, Australia..en
dc.identifier.affiliationDepartment of Neurology, Alfred Health, Melbourne, VIC 3004, Australia..en
dc.identifier.affiliationDepartment of Neuroscience, Monash University, Melbourne, VIC 3004, Australia..en
dc.identifier.affiliationMedicine (University of Melbourne)en
dc.identifier.affiliationComprehensive Epilepsy Programen
dc.identifier.affiliationRoyal Brisbane and Women's Hospital and School of Medicine and Biomedical Science, University of Queensland, Brisbane, QLD 4027, Australia..en
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/35863138/en
dc.identifier.doi10.1016/j.yebeh.2022.108848en
dc.type.contentTexten
dc.identifier.orcid0000-0002-7855-7066en
dc.identifier.pubmedid35863138-
local.name.researcherPerucca, Piero
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptNeurology-
crisitem.author.deptComprehensive Epilepsy Program-
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