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dc.contributor.authorSharma, Varun J-
dc.contributor.authorArghami, Arman-
dc.contributor.authorPasupula, Deepak Kumar-
dc.contributor.authorHaddad, Abdullah-
dc.contributor.authorKe, Janny Xue Chen-
dc.identifier.citationHeart, lung & circulation 2022; 31(7): 916-923en
dc.description.abstractOur objective is to assess whether the presence of myocardial viability is a predictor of mortality among patients undergoing coronary artery bypasss grafting (CABG) through a systematic review meta-analysis. Comprehensive review of EMBASE and PubMed in accordance with PRISMA guidelines, including studies of patients undergoing CABG with assessment of myocardial viability and recorded long-term mortality, age and sex. Studies were restricted to the last decade, and data were stratified by imaging modality (magnetic resonance imaging [MRI] or nuclear medicine). Random-effects model for assessing pooled effect, heterogeneity assessment using Chi-square and I2 statistics, publication bias assessed by funnel plots and Egger's test. Meta-analysis of contemporary data (January 2010 to October 2020) yielded 3,621 manuscripts of which 92 were relevant, and 6 appropriate for inclusion with 993 patients. Pooled analysis showed that patients with non-viable myocardium undergoing CABG are at 1.34 times the risk of mortality compared to those with viable myocardium (95% CI 1.01-1.79, p=0.05). Subgroup analysis of the MRI or nuclear medicine modalities was not statistically significant and there was no confounding by age or sex in meta-regression. There was significant heterogeneity in imaging modality and diagnostic criteria, but heterogeneity between study findings was low with an I2 statistic of 29%. The risk of publication bias was moderate on the Newcastle-Ottawa Scale), but not statistically significant (Egger's Test coefficient=1.3, 95%CI -0.35-2.61, p=0.10). There is a multitude of methods for assessing cardiac viability for coronary revascularisation surgery, making meta-analyses fraught with limitations. Our meta-analysis demonstrates that the finding of non-viable myocardium can not be used draw conclusions for risk assessment in coronary surgery.en
dc.subjectCoronary artery bypass graftingen
dc.subjectMyocardial viabilityen
dc.titleOutcomes of Coronary Artery Bypass Grafting in Patients With Poor Myocardial Viability: A Systematic Review and Meta-Analysis of the Last Decade.en
dc.typeJournal Articleen
dc.identifier.journaltitleHeart, lung & circulationen
dc.identifier.affiliationCardiac Surgeryen
dc.identifier.affiliationDepartment of Cardiovascular Surgery, Mayo Clinic, Rochester, MN, USA..en
dc.identifier.affiliationDepartment of Cardiology, MercyOne North Iowa Medical Center, Mason City, IA, USA..en
dc.identifier.affiliationHarvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA..en
dc.identifier.affiliationDepartment of Anesthesia, Pain Management & Perioperative Medicine, Dalhousie University, Halifax, Canada..en
dc.identifier.affiliationDepartment of Anesthesia, Providence Health Care, Vancouver, Canada..en
dc.identifier.affiliationDepartment of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada..en
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item.openairetypeJournal Article-
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