Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30478
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dc.contributor.authorRobba, Chiara-
dc.contributor.authorBadenes, Rafael-
dc.contributor.authorBattaglini, Denise-
dc.contributor.authorBall, Lorenzo-
dc.contributor.authorBrunetti, Iole-
dc.contributor.authorJakobsen, Janus C-
dc.contributor.authorLilja, Gisela-
dc.contributor.authorFriberg, Hans-
dc.contributor.authorWendel-Garcia, Pedro D-
dc.contributor.authorYoung, Paul J-
dc.contributor.authorEastwood, Glenn M-
dc.contributor.authorChew, Michelle S-
dc.contributor.authorUnden, Johan-
dc.contributor.authorThomas, Matthew-
dc.contributor.authorJoannidis, Michael-
dc.contributor.authorNichol, Alistair-
dc.contributor.authorLundin, Andreas-
dc.contributor.authorHollenberg, Jacob-
dc.contributor.authorHammond, Naomi-
dc.contributor.authorSaxena, Manoj-
dc.contributor.authorAnnborn, Martin-
dc.contributor.authorSolar, Miroslav-
dc.contributor.authorTaccone, Fabio S-
dc.contributor.authorDankiewicz, Josef-
dc.contributor.authorNielsen, Niklas-
dc.contributor.authorPelosi, Paolo-
dc.date2022-
dc.date.accessioned2022-07-06T06:23:28Z-
dc.date.available2022-07-06T06:23:28Z-
dc.date.issued2022-07-02-
dc.identifier.citationIntensive Care Medicine 2022; 48(8): 1024-1038en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/30478-
dc.description.abstractThe optimal ventilatory settings in patients after cardiac arrest and their association with outcome remain unclear. The aim of this study was to describe the ventilatory settings applied in the first 72 h of mechanical ventilation in patients after out-of-hospital cardiac arrest and their association with 6-month outcomes. Preplanned sub-analysis of the Target Temperature Management-2 trial. Clinical outcomes were mortality and functional status (assessed by the Modified Rankin Scale) 6 months after randomization. A total of 1848 patients were included (mean age 64 [Standard Deviation, SD = 14] years). At 6 months, 950 (51%) patients were alive and 898 (49%) were dead. Median tidal volume (VT) was 7 (Interquartile range, IQR = 6.2-8.5) mL per Predicted Body Weight (PBW), positive end expiratory pressure (PEEP) was 7 (IQR = 5-9) cmH20, plateau pressure was 20 cmH20 (IQR = 17-23), driving pressure was 12 cmH20 (IQR = 10-15), mechanical power 16.2 J/min (IQR = 12.1-21.8), ventilatory ratio was 1.27 (IQR = 1.04-1.6), and respiratory rate was 17 breaths/minute (IQR = 14-20). Median partial pressure of oxygen was 87 mmHg (IQR = 75-105), and partial pressure of carbon dioxide was 40.5 mmHg (IQR = 36-45.7). Respiratory rate, driving pressure, and mechanical power were independently associated with 6-month mortality (omnibus p-values for their non-linear trajectories: p < 0.0001, p = 0.026, and p = 0.029, respectively). Respiratory rate and driving pressure were also independently associated with poor neurological outcome (odds ratio, OR = 1.035, 95% confidence interval, CI = 1.003-1.068, p = 0.030, and OR = 1.005, 95% CI = 1.001-1.036, p = 0.048). A composite formula calculated as [(4*driving pressure) + respiratory rate] was independently associated with mortality and poor neurological outcome. Protective ventilation strategies are commonly applied in patients after cardiac arrest. Ventilator settings in the first 72 h after hospital admission, in particular driving pressure and respiratory rate, may influence 6-month outcomes.en
dc.language.isoeng-
dc.subjectCardiac arresten
dc.subjectDriving pressureen
dc.subjectMechanical poweren
dc.subjectMechanical ventilationen
dc.subjectOutcomeen
dc.subjectVentilator settingsen
dc.titleVentilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial.en
dc.typeJournal Articleen
dc.identifier.journaltitleIntensive care medicineen
dc.identifier.affiliationDepartment of Critical Care, University of Melbourne, Parkville, VIC, Australia..en
dc.identifier.affiliationMedical Research Institute of New Zealand, Private Bag 7902, Wellington, 6242, New Zealand..en
dc.identifier.affiliationIntensive Care Unit, St George Hospital, Sydney, Australia..en
dc.identifier.affiliationMalcolm Fisher Department of Intensive Care, Royal North Shore Hospital, Critical Care Division, The George Institute for Global Health, Faculty of Medicine, UNSW Sydney, Sydney, Australia..en
dc.identifier.affiliationMonash University, Melbourne, VIC, Australia..en
dc.identifier.affiliationIntensive Careen
dc.identifier.affiliationAnesthesia and Critical Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neuroscience, Genoa, Italy..en
dc.identifier.affiliationDepartment of Anesthesiology and Surgical-Trauma Intensive Care, Hospital Clínic Universitari de Valencia, Valencia, Spain..en
dc.identifier.affiliationDepartment of Surgical Sciences and Integrated Diagnostics, University of Genoa, Viale Benedetto XV 16, Genoa, Italy..en
dc.identifier.affiliationDepartment of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark..en
dc.identifier.affiliationCopenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark..en
dc.identifier.affiliationDepartment of Clinical Sciences Lund, Neurology, Skåne University Hospital, Lund University, Getingevägen 4, 222 41, Lund, Sweden..en
dc.identifier.affiliationDepartment of Clinical Sciences Lund, Anesthesia and Intensive Care, Lund University, Lund, Sweden..en
dc.identifier.affiliationInstitute of Intensive Care Medicine, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland..en
dc.identifier.affiliationDepartment of Anaesthesia and Intensive Care, Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden..en
dc.identifier.affiliationDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden..en
dc.identifier.affiliationUniversity Hospitals Bristol NHS Foundation Trust, Bristol, UK..en
dc.identifier.affiliationDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria..en
dc.identifier.affiliationDepartment of Anaesthesiology and Intensive Care Medicine, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 423 45, Gothenburg, Sweden..en
dc.identifier.affiliationDepartment of Medicine, Centre for Resuscitation Science, Karolinska Institutet, Södersjukhuset Sjukhusbacken 10, Solna, 118 83, Stockholm, Sweden..en
dc.identifier.affiliationDepartment of Clinical Medicine, Anaesthesiology and Intensive Care, Lund University, Lund, Sweden..en
dc.identifier.affiliationDepartment of Internal Medicine, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic..en
dc.identifier.affiliationDepartment of Intensive Care Medicine, Université Libre de Bruxelles, Hopital Erasme, Brussels, Belgium..en
dc.identifier.affiliationDepartment of Clinical Sciences Lund, Cardiology, Skåne University Hospital, Lund University, Lund, Sweden..en
dc.identifier.affiliationDepartment of Clinical Sciences Lund, Anaesthesia and Intensive Care and Clinical Sciences Helsingborg, Helsingborg Hospital, Lund University, Lund, Sweden..en
dc.identifier.affiliationIntensive Care Unit, Wellington Regional Hospital, Wellington, New Zealand..en
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia..en
dc.identifier.affiliationDepartment of Surgical Sciences and Integrated Diagnostics, University of Genoa, Viale Benedetto XV 16, Genoa, Italy..en
dc.identifier.affiliationDepartment of Surgery, University of Valencia, Valencia, Spain..en
dc.identifier.affiliationDepartment of Medicine, University of Barcelona, Barcelona, Spain..en
dc.identifier.affiliationDepartment of Operation and Intensive Care, Lund University, Hallands Hospital Halmstad, Halland, Sweden..en
dc.identifier.affiliationDepartment of Internal Medicine-Cardioangiology, University Hospital Hradec Králové, Hradec Králové, Czech Republic..en
dc.identifier.affiliationDepartment of Surgical Sciences and Integrated Diagnostics, University of Genoa, Viale Benedetto XV 16, Genoa, Italy..en
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/35780195/en
dc.identifier.doi10.1007/s00134-022-06756-4en
dc.type.contentTexten
dc.identifier.orcidhttp://orcid.org/0000-0003-1628-3845en
dc.identifier.orcidhttp://orcid.org/0000-0001-7700-9933en
dc.identifier.pubmedid35780195-
local.name.researcherEastwood, Glenn M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
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