Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30382
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKhanijou, Vuthi-
dc.contributor.authorZafari, Neda-
dc.contributor.authorCoughlan, Melinda T-
dc.contributor.authorMacIsaac, Richard J-
dc.contributor.authorEkinci, Elif I-
dc.date2022-
dc.date.accessioned2022-06-23T00:40:34Z-
dc.date.available2022-06-23T00:40:34Z-
dc.date.issued2022-06-16-
dc.identifier.citationDiabetes/Metabolism Research and Reviews 2022; 38(6): e3556en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/30382-
dc.description.abstractDiabetic kidney disease is expected to increase rapidly over the coming decades with rising prevalence of diabetes worldwide. Current measures of kidney function based on albuminuria and estimated glomerular filtration rate do not accurately stratify and predict individuals at risk of declining kidney function in diabetes. As a result, recent attention has turned towards identifying and assessing the utility of biomarkers in diabetic kidney disease. This review explores the current literature on biomarkers of inflammation and kidney injury focusing on studies of single or multiple biomarkers between January 2014 and February 2020. Multiple serum and urine biomarkers of inflammation and kidney injury have demonstrated significant association with the development and progression of diabetic kidney disease. Of the inflammatory biomarkers, tumour necrosis factor receptor-1 and -2 were frequently studied and appear to hold most promise as markers of diabetic kidney disease. With regards to kidney injury biomarkers, studies have largely targeted markers of tubular injury of which kidney injury molecule-1, beta-2-microglobulin and neutrophil gelatinase-associated lipocalin emerged as potential candidates. Finally, the use of a small panel of selective biomarkers appears to perform just as well as a panel of multiple biomarkers for predicting kidney function decline. This article is protected by copyright. All rights reserved.en
dc.language.isoeng-
dc.subjectBiomarkersen
dc.subjectDiabetic Kidney Diseaseen
dc.subjectInflammationen
dc.subjectKidney Injuryen
dc.subjectKidney Injury Molecule-1 [KIM-1]en
dc.subjectTumour Necrosis Factor Receptor [TNFR]en
dc.titleReview of potential biomarkers of inflammation and kidney injury in diabetic kidney disease.en
dc.typeJournal Articleen
dc.identifier.journaltitleDiabetes/metabolism research and reviewsen
dc.identifier.affiliationEndocrinologyen
dc.identifier.affiliationDepartment of Diabetes, Central Clinical School, Monash University, Alfred Medical Research Alliance, Melbourne, Victoria, Australia..en
dc.identifier.affiliationBaker Heart & Diabetes Institute, Melbourne, Victoria, Australia..en
dc.identifier.affiliationDepartment of Endocrinology & Diabetes, St. Vincent's Hospital Melbourne and University of Melbourne, Melbourne, Victoria, Australia..en
dc.identifier.affiliationMelbourne Medical School, University of Melbourne, Austin Health, Melbourne, Victoria, Australia..en
dc.identifier.affiliationMedicine (University of Melbourne)en
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/35708187/en
dc.identifier.doi10.1002/dmrr.3556en
dc.type.contentTexten
dc.identifier.orcidhttps://orcid.org/0000-0001-7402-3190en
dc.identifier.orcid0000-0002-8010-4082en
dc.identifier.orcid0000-0003-2372-395Xen
dc.identifier.pubmedid35708187-
local.name.researcherEkinci, Elif I
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptEndocrinology-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

40
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.