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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30320
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dc.contributor.authorCadby, Gemma-
dc.contributor.authorGiles, Corey-
dc.contributor.authorMelton, Phillip E-
dc.contributor.authorHuynh, Kevin-
dc.contributor.authorMellett, Natalie A-
dc.contributor.authorDuong, Thy-
dc.contributor.authorNguyen, Anh-
dc.contributor.authorCinel, Michelle-
dc.contributor.authorSmith, Alex-
dc.contributor.authorOlshansky, Gavriel-
dc.contributor.authorWang, Tingting-
dc.contributor.authorBrozynska, Marta-
dc.contributor.authorInouye, Mike-
dc.contributor.authorMcCarthy, Nina S-
dc.contributor.authorAriff, Amir-
dc.contributor.authorHung, Joseph-
dc.contributor.authorHui, Jennie-
dc.contributor.authorBeilby, John-
dc.contributor.authorDubé, Marie-Pierre-
dc.contributor.authorWatts, Gerald F-
dc.contributor.authorShah, Sonia-
dc.contributor.authorWray, Naomi R-
dc.contributor.authorLim, Wei Ling Florence-
dc.contributor.authorChatterjee, Pratishtha-
dc.contributor.authorMartins, Ian-
dc.contributor.authorLaws, Simon M-
dc.contributor.authorPorter, Tenielle-
dc.contributor.authorVacher, Michael-
dc.contributor.authorBush, Ashley I-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorAmes, David-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorTaddei, Kevin-
dc.contributor.authorArnold, Matthias-
dc.contributor.authorKastenmüller, Gabi-
dc.contributor.authorNho, Kwangsik-
dc.contributor.authorSaykin, Andrew J-
dc.contributor.authorHan, Xianlin-
dc.contributor.authorKaddurah-Daouk, Rima-
dc.contributor.authorMartins, Ralph N-
dc.contributor.authorBlangero, John-
dc.contributor.authorMeikle, Peter J-
dc.contributor.authorMoses, Eric K-
dc.date2022-
dc.date.accessioned2022-06-23T00:37:55Z-
dc.date.available2022-06-23T00:37:55Z-
dc.date.issued2022-06-06-
dc.identifier.citationNature communications 2022; 13(1): 3124en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/30320-
dc.description.abstractWe integrated lipidomics and genomics to unravel the genetic architecture of lipid metabolism and identify genetic variants associated with lipid species putatively in the mechanistic pathway for coronary artery disease (CAD). We quantified 596 lipid species in serum from 4,492 individuals from the Busselton Health Study. The discovery GWAS identified 3,361 independent lipid-loci associations, involving 667 genomic regions (479 previously unreported), with validation in two independent cohorts. A meta-analysis revealed an additional 70 independent genomic regions associated with lipid species. We identified 134 lipid endophenotypes for CAD associated with 186 genomic loci. Associations between independent lipid-loci with coronary atherosclerosis were assessed in ∼456,000 individuals from the UK Biobank. Of the 53 lipid-loci that showed evidence of association (P < 1 × 10-3), 43 loci were associated with at least one lipid endophenotype. These findings illustrate the value of integrative biology to investigate the aetiology of atherosclerosis and CAD, with implications for other complex diseases.en
dc.language.isoeng
dc.titleComprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.en
dc.typeJournal Articleen
dc.identifier.journaltitleNature communicationsen
dc.identifier.affiliationSchool of Population and Global Health, University of Western Australia, Crawley, WA, Australia..en
dc.identifier.affiliationBaker Heart and Diabetes Institute, Melbourne, VIC, Australia..en
dc.identifier.affiliationBaker Department of Cardiometabolic Health, University of Melbourne, Melbourne, VIC, Australia..en
dc.identifier.affiliationMenzies Research Institute, University of Tasmania, Hobart, TAS, Australia..en
dc.identifier.affiliationSchool of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia..en
dc.identifier.affiliationSchool of Women's and Children's Health, University of New South Wales, Sydney, NSW, Australia..en
dc.identifier.affiliationSchool of Medicine, The University of Western Australia, Crawley, WA, Australia..en
dc.identifier.affiliationDepartment of Cardiovascular Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia..en
dc.identifier.affiliationBusselton Population Medical Research Institute Inc., Perth, WA, Australia..en
dc.identifier.affiliationPathWest Laboratory Medicine WA, Perth, WA, Australia..en
dc.identifier.affiliationUniversité de Montréal Beaulieu-Saucier Pharmacogenomics Centre, Montreal Heart Institute, Montreal, QC, Canada..en
dc.identifier.affiliationLipid Disorders Clinic, Department of Cardiology, Royal Perth Hospital, Perth, WA, Australia..en
dc.identifier.affiliationInstitute for Molecular Biosciences, University of Queensland, Brisbane, QLD, Australia..en
dc.identifier.affiliationQueensland Brain Institute, University of Queensland, Brisbane, QLD, Australia..en
dc.identifier.affiliationSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia..en
dc.identifier.affiliationCooperative research Centre (CRC) for Mental Health, Joondalup, WA, Australia..en
dc.identifier.affiliationDepartment of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia..en
dc.identifier.affiliationKaRa Institute of Neurological Disease, Sydney, Macquarie Park, NSW, Australia..en
dc.identifier.affiliationCentre for Precision Health, Edith Cowan University, Joondalup, WA, Australia..en
dc.identifier.affiliationCollaborative Genomics Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia..en
dc.identifier.affiliationCurtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia..en
dc.identifier.affiliationThe Australian e-Health Research Centre, Health and Biosecurity, CSIRO, Floreat, WA, Australia..en
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen
dc.identifier.affiliationMolecular Imaging and Therapyen
dc.identifier.affiliationMedicine (University of Melbourne)en
dc.identifier.affiliationNational Ageing Research Institute, Parkville, VIC, Australia..en
dc.identifier.affiliationUniversity of Melbourne Academic Unit for Psychiatry of Old Age, St George's Hospital, Kew, VIC, Australia..en
dc.identifier.affiliationDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA..en
dc.identifier.affiliationInstitute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany..en
dc.identifier.affiliationDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA..en
dc.identifier.affiliationCenter for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA..en
dc.identifier.affiliationIndiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA..en
dc.identifier.affiliationDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA..en
dc.identifier.affiliationBarshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA..en
dc.identifier.affiliationDuke Institute of Brain Sciences, Duke University, Durham, NC, USA..en
dc.identifier.affiliationDepartment of Medicine, Duke University, Durham, NC, USA..en
dc.identifier.affiliationSouth Texas Diabetes and Obesity Institute, The University of Texas Rio Grande Valley, Brownsville, TX, USA..en
dc.identifier.affiliationMonash University, Melbourne, VIC, Australia..en
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/35668104/en
dc.identifier.doi10.1038/s41467-022-30875-7en
dc.type.contentTexten
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dc.identifier.pubmedid35668104
local.name.researcherMasters, Colin L
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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