Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30293
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dc.contributor.authorMeyer, Ilonka-
dc.contributor.authorChan, Brandon-
dc.contributor.authorCohen, Emma-
dc.contributor.authorDube, Esther-
dc.contributor.authorHu, Raymond T C-
dc.contributor.authorYeomans, Megan-
dc.contributor.authorPontonio, Frances-
dc.contributor.authorHeldreich, Charlotte-
dc.contributor.authorO'Conghaile, Stiofan-
dc.contributor.authorHolmes, Natasha E-
dc.contributor.authorMaroon, Nada-
dc.contributor.authorWeinberg, Laurence-
dc.contributor.authorTan, Chong O-
dc.date2022-
dc.date.accessioned2022-06-23T00:35:06Z-
dc.date.available2022-06-23T00:35:06Z-
dc.date.issued2022-07-
dc.identifier.citationSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2022; 30(7): 6013-6020en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/30293-
dc.description.abstractThe aim of this study is to ascertain the analgesic efficacy and total oral morphine equivalent daily dose (OMEDD) effect of a buprenorphine-based analgesic protocol in the treatment of severe Oral Mucositis (OM). This is a retrospective cohort study. This study was done in a single Quaternary Referral Centre, Haematology Unit. Fifty-four stem cell transplant patients suffering at least grade 3 oral mucositis (OM), 24 prior to [Pr-I] and 30 subsequent to [Po-I] a buprenorphine-based OM analgesic protocol. We analysed data from the above subjects with the primary outcome measure of difference in total OMEDDs from all opioid types and administration routes, and secondary outcome measures of area under the curve (AUC) of 11-point Numerical Rating Scale (NRS-11) pain assessments, sedation scores and respiratory rate. Post-protocol patients' total OMEDD requirements were significantly reduced [Pr-I: 1961 (1365)mg; Po-I: 928 (625)mg, p = 0.02], as were total NRS-11:hours AUC on swallowing [Pr-I: 54(24) score-hours; Po-I: 41(18) score-hours, p < 0.001]. There were no significant differences in objective measures of OM severity between groups (Number of Grade 3 or 4 OM severity assessments [mean (SD)] Pr-I: 5 (6.2); Po-I: 7 (5.1) or number of days Neutrophil count 0.0 or 0.1 × 109/L; Pr-I: 13 (5.4); Po-I: 15 (4.7)). 5 Pr-I and 4 Po-I patients required ketamine infusions, with 1 Pr-I patient also requiring IV lignocaine. Use of Buprenorphine via transdermal, sublingual and intravenous Patient Controlled Analgesia (PCA) delivery as part of an analgesic protocol for severe post stem cell transplant oral mucositis in adult patients appears to significantly reduce opioid requirements and pain on swallowing. Further randomised prospective work is required to confirm these associations.en
dc.language.isoeng
dc.subjectAcute painen
dc.subjectBuprenorphineen
dc.subjectCancer painen
dc.subjectOpioiden
dc.subjectOral mucositisen
dc.subjectStem cell transplanten
dc.titleUse of a buprenorphine-based pain management protocol is associated with reduced opioid requirements and pain on swallowing in oral mucositis: a retrospective cohort study.en
dc.typeJournal Articleen
dc.identifier.journaltitleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Canceren
dc.identifier.affiliationPain Serviceen
dc.identifier.affiliationData Analytics Research and Evaluation (DARE) Centreen
dc.identifier.affiliationClinical Haematologyen
dc.identifier.affiliationAnaesthesiaen
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/35403901/en
dc.identifier.doi10.1007/s00520-022-07014-5en
dc.type.contentTexten
dc.identifier.orcid0000-0002-8025-9519en
dc.identifier.orcid0000-0002-0169-0600en
dc.identifier.orcid0000-0003-2423-9385en
dc.identifier.orcid0000-0003-1161-8239en
dc.identifier.orcid0000-0002-2194-9915en
dc.identifier.orcid0000-0001-8501-4054en
dc.identifier.orcid0000-0001-7403-7680en
dc.identifier.pubmedid35403901
local.name.researcherCohen, Emma
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
crisitem.author.deptAnaesthesia-
crisitem.author.deptAnaesthesia-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
crisitem.author.deptAnaesthesia-
crisitem.author.deptAnaesthesia-
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