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dc.contributor.authorRonco, Claudio-
dc.contributor.authorBellomo, Rinaldo-
dc.identifier.citationCritical care 2022; 26(1): 135en
dc.description.abstractBlood purification through the removal of plasma solutes by adsorption to beads of charcoal or resins contained in a cartridge (hemoperfusion) has a long and imperfect history. Developments in production and coating technology, however, have recently increased the biocompatibility of sorbents and have spurred renewed interest in hemoperfusion. We performed a narrative assessment of the literature with focus on the technology, characteristics, and principles of hemoperfusion. We assessed publications in ex vivo, animal, and human studies. We synthesized such literature in a technical and state-of-the-art summary. Early hemoperfusion studies were hampered by bioincompatibility. Recent technology, however, has improved its safety. Hemoperfusion has been used with positive effects in chronic dialysis and chronic liver disease. It has also demonstrated extraction of a variety of toxins and drugs during episodes of overdose. Trials with endotoxin binding polymyxin B have shown mixed results in septic shock and are under active investigation. The role of non-selective hemoperfusion in sepsis or inflammation remains. Although new technologies have made sorbents more biocompatible, the research agenda in the field remains vast. New sorbents markedly differ from those used in the past because of greater biocompatibility and safety. Initial studies of novel sorbent-based hemoperfusion show some promise in specific chronic conditions and some acute states. Systematic studies of novel sorbent-based hemoperfusion are now both necessary and justified.en
dc.titleHemoperfusion: technical aspects and state of the art.en
dc.typeJournal Articleen
dc.identifier.journaltitleCritical care (London, England)en
dc.identifier.affiliationData Analytics Research and Evaluation (DARE) Centreen
dc.identifier.affiliationIntensive Care..en
dc.identifier.affiliationDepartment of Intensive Care, Royal Melbourne Hospital, Melbourne, Australia..en
dc.identifier.affiliationDepartment of Critical Care, University of Melbourne, Melbourne, Australia..en
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia..en
dc.identifier.affiliationDepartment of Medicine, University of Padova, Padua, Italy..en
dc.identifier.affiliationInternational Renal Research Institute of Vicenza (IRRV), Vicenza, Italy..en
dc.identifier.affiliationDepartment of Nephrology, San Bortolo Hospital, Vicenza, Italy..en
dc.identifier.pubmedid35549999, Rinaldo
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristype Care- Analytics Research and Evaluation (DARE) Centre-
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