Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30195
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dc.contributor.authorSharmin, Sifat-
dc.contributor.authorBovis, Francesca-
dc.contributor.authorMalpas, Charles-
dc.contributor.authorHorakova, Dana-
dc.contributor.authorHavrdova, Eva Kubala-
dc.contributor.authorIzquierdo, Guillermo-
dc.contributor.authorEichau, Sara-
dc.contributor.authorTrojano, Maria-
dc.contributor.authorPrat, Alexandre-
dc.contributor.authorGirard, Marc-
dc.contributor.authorDuquette, Pierre-
dc.contributor.authorOnofrj, Marco-
dc.contributor.authorLugaresi, Alessandra-
dc.contributor.authorGrand'Maison, Francois-
dc.contributor.authorGrammond, Pierre-
dc.contributor.authorSola, Patrizia-
dc.contributor.authorFerraro, Diana-
dc.contributor.authorTerzi, Murat-
dc.contributor.authorGerlach, Oliver-
dc.contributor.authorAlroughani, Raed-
dc.contributor.authorBoz, Cavit-
dc.contributor.authorShaygannejad, Vahid-
dc.contributor.authorvan Pesch, Vincent-
dc.contributor.authorCartechini, Elisabetta-
dc.contributor.authorKappos, Ludwig-
dc.contributor.authorLechner-Scott, Jeannette-
dc.contributor.authorBergamaschi, Roberto-
dc.contributor.authorTurkoglu, Recai-
dc.contributor.authorSolaro, Claudio-
dc.contributor.authorIuliano, Gerardo-
dc.contributor.authorGranella, Franco-
dc.contributor.authorVan Wijmeersch, Bart-
dc.contributor.authorSpitaleri, Daniele-
dc.contributor.authorSlee, Mark-
dc.contributor.authorMcCombe, Pamela-
dc.contributor.authorPrevost, Julie-
dc.contributor.authorAmpapa, Radek-
dc.contributor.authorOzakbas, Serkan-
dc.contributor.authorSanchez-Menoyo, Jose Luis-
dc.contributor.authorSoysal, Aysun-
dc.contributor.authorVucic, Steve-
dc.contributor.authorPetersen, Thor-
dc.contributor.authorde Gans, Koen-
dc.contributor.authorButler, Ernest-
dc.contributor.authorHodgkinson, Suzanne-
dc.contributor.authorSidhom, Youssef-
dc.contributor.authorGouider, Riadh-
dc.contributor.authorCristiano, Edgardo-
dc.contributor.authorCastillo-Triviño, Tamara-
dc.contributor.authorSaladino, Maria Laura-
dc.contributor.authorBarnett, Michael-
dc.contributor.authorMoore, Fraser-
dc.contributor.authorRozsa, Csilla-
dc.contributor.authorYamout, Bassem-
dc.contributor.authorSkibina, Olga-
dc.contributor.authorvan der Walt, Anneke-
dc.contributor.authorBuzzard, Katherine-
dc.contributor.authorGray, Orla-
dc.contributor.authorHughes, Stella-
dc.contributor.authorSempere, Angel Perez-
dc.contributor.authorSinghal, Bhim-
dc.contributor.authorFragoso, Yara-
dc.contributor.authorShaw, Cameron-
dc.contributor.authorKermode, Allan-
dc.contributor.authorTaylor, Bruce-
dc.contributor.authorSimo, Magdolna-
dc.contributor.authorShuey, Neil-
dc.contributor.authorAl-Harbi, Talal-
dc.contributor.authorMacdonell, Richard A L-
dc.contributor.authorDominguez, Jose Andres-
dc.contributor.authorCsepany, Tunde-
dc.contributor.authorSirbu, Carmen Adella-
dc.contributor.authorSormani, Maria Pia-
dc.contributor.authorButzkueven, Helmut-
dc.contributor.authorKalincik, Tomas-
dc.date2022-06-09-
dc.date.accessioned2022-06-23T00:29:11Z-
dc.date.available2022-06-23T00:29:11Z-
dc.date.issued2022-08-
dc.identifier.citationEuropean Journal of Neurology 2022; 29(8): 2321-2334en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/30195-
dc.description.abstractThe prevention of disability over the long term is the main treatment goal in multiple sclerosis (MS); however, randomized clinical trials evaluate only short-term treatment effects on disability. This study aimed to define criteria for 6-month confirmed disability progression events of MS with a high probability of resulting in sustained long-term disability worsening. In total, 14,802 6-month confirmed disability progression events were identified in 8741 patients from the global MSBase registry. For each 6-month confirmed progression event (13,321 in the development and 1481 in the validation cohort), a sustained progression score was calculated based on the demographic and clinical characteristics at the time of progression that were predictive of long-term disability worsening. The score was externally validated in the Cladribine Tablets Treating Multiple Sclerosis Orally (CLARITY) trial. The score was based on age, sex, MS phenotype, relapse activity, disability score and its change from baseline, number of affected functional system domains and worsening in six of the domains. In the internal validation cohort, a 61% lower chance of improvement was estimated with each unit increase in the score (hazard ratio 0.39, 95% confidence interval 0.29-0.52; discriminatory index 0.89). The proportions of progression events sustained at 5 years stratified by the score were 1: 72%; 2: 88%; 3: 94%; 4: 100%. The results of the CLARITY trial were confirmed for reduction of disability progression that was >88% likely to be sustained (events with score ˃1.5). Clinicodemographic characteristics of 6-month confirmed disability progression events identify those at high risk of sustained long-term disability. This knowledge will allow future trials to better assess the effect of therapy on long-term disability accrual.en
dc.language.isoeng-
dc.subjectCLARITYen
dc.subjectclinical trialen
dc.subjectfunctional system impairmenten
dc.subjectrisk scoringen
dc.subjectsustained disability progressionen
dc.titleConfirmed disability progression as a marker of permanent disability in multiple sclerosis.en
dc.typeJournal Articleen
dc.identifier.journaltitleEuropean Journal of Neurologyen
dc.identifier.affiliationAustin Healthen
dc.identifier.affiliationSouth East Trust, Belfast, UKen
dc.identifier.affiliationCraigavon Area Hospital, Craigavon, UKen
dc.identifier.affiliationWestmead Hospital, Sydney, NSW, Australiaen
dc.identifier.affiliationMonash Medical Centre, Melbourne, Vic., Australiaen
dc.identifier.affiliationLiverpool Hospital, Sydney, NSW, Australiaen
dc.identifier.affiliationBrain and Mind Centre, Sydney, NSW, Australiaen
dc.identifier.affiliationCentral Clinical School, Monash University, Melbourne, Vic., Australiaen
dc.identifier.affiliationDepartment of Neurology, The Alfred Hospital, Melbourne, Vic., Australiaen
dc.identifier.affiliationGeelong Hospital, Geelong, Vic., Australiaen
dc.identifier.affiliationRoyal Hobart Hospital, Hobart, TAS, Australiaen
dc.identifier.affiliationSt Vincents Hospital, Fitzroy, Melbourne, Vic., Australiaen
dc.identifier.affiliationFlinders University, Adelaide, SA, Australiaen
dc.identifier.affiliationUniversity of Queensland, Brisbane, Qld, Australiaen
dc.identifier.affiliationRoyal Brisbane and Women's Hospital, Brisbane, Qld, Australiaen
dc.identifier.affiliationCORe, Department of Medicine, University of Melbourne, Melbourne, Australiaen
dc.identifier.affiliationSir Charles Gairdner Hospital, Nedlands, WA, Australiaen
dc.identifier.affiliationMelbourne MS Centre, Department of Neurology, Royal Melbourne Hospital, Melbourne, Australiaen
dc.identifier.affiliationSchool of Medicine and Public Health, University Newcastle, Newcastle, NSW, Australiaen
dc.identifier.affiliationDepartment of Neurology, John Hunter Hospital, Hunter New England Health, Newcastle, NSW, Australiaen
dc.identifier.affiliationPerron Institute, University of Western Australia, Nedlands, WA, Australiaen
dc.identifier.affiliationInstitute of Immunology and Infectious Diseases, Murdoch University, Perth, WA, Australiaen
dc.identifier.affiliationDepartment of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republicen
dc.identifier.affiliationHospital Universitario Virgen Macarena, Sevilla, Spainen
dc.identifier.affiliationDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Bari, Italyen
dc.identifier.affiliationHopital Notre Dame, Montreal, QC, Canada.. CHUM and Universite de Montreal, Montreal, QC, Canadaen
dc.identifier.affiliationDepartment of Neuroscience, Imaging, and Clinical Sciences, University G. d'Annunzio, Chieti, Italyen
dc.identifier.affiliationIRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italia.. Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italiaen
dc.identifier.affiliationNeuro Rive-Sud, Greenfield Park, QC, Canadaen
dc.identifier.affiliationCISSS Chaudière-Appalache, Levis, QC, Canadaen
dc.identifier.affiliationDepartment of Neuroscience, Azienda Ospedaliera Universitaria, Modena, Italyen
dc.identifier.affiliationMedical Faculty, 19 Mayis University, Samsun, Turkeyen
dc.identifier.affiliationDepartment of Neurology, Zuyderland Medical Center, Sittard-Geleen, The Netherlandsen
dc.identifier.affiliationDivision of Neurology, Department of Medicine, Amiri Hospital, Sharq, Kuwaiten
dc.identifier.affiliationKTU Medical Faculty Farabi Hospital, Trabzon, Turkeyen
dc.identifier.affiliationIsfahan University of Medical Sciences, Isfahan, Iranen
dc.identifier.affiliationCliniques Universitaires Saint-Luc, Brussels, Belgium.. Université Catholique de Louvain, Louvain-la-Neuve, Belgiumen
dc.identifier.affiliationUOC Neurologia, Azienda Sanitaria Unica Regionale Marche - AV3, Macerata, Italyen
dc.identifier.affiliationNeurologic Clinic and Policlinic, Departments of Medicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerlanden
dc.identifier.affiliationIRCCS Mondino Foundation, Pavia, Italyen
dc.identifier.affiliationHaydarpasa Numune Training and Research Hospital, Istanbul, Turkeyen
dc.identifier.affiliationDepartment of Rehabilitaiton, ML Novarese Hospital, Moncrivello, Italyen
dc.identifier.affiliationOspedali Riuniti di Salerno, Salerno, Italyen
dc.identifier.affiliationDepartment of Medicine and Surgery, University of Parma, Parma, Italyen
dc.identifier.affiliationRehabilitation and MS-Centre Overpelt and Hasselt University, Hasselt, Belgiumen
dc.identifier.affiliationAzienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino, Avellino, Italyen
dc.identifier.affiliationCSSS Saint-Jerome, Saint-Jérôme, QC, Canadaen
dc.identifier.affiliationNemocnice Jihlava, Jihlava, Czech Republicen
dc.identifier.affiliationDokuz Eylul University, Konak/Izmir, Turkeyen
dc.identifier.affiliationHospital de Galdakao-Usansolo, Galdakao, Spainen
dc.identifier.affiliationBakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases, Istanbul, Turkeyen
dc.identifier.affiliationUniversity hospital Aarhus, Aarhus, Denmarken
dc.identifier.affiliationGroene Hart Ziekenhuis, Gouda, The Netherlandsen
dc.identifier.affiliationDepartment of Neurology, Razi Hospital, Manouba, Tunisiaen
dc.identifier.affiliationHospital Italiano, Buenos Aires, Argentinaen
dc.identifier.affiliationInstituto de Investigación Sanitaria Biodonostia, Department of Neurology, Hospital Universitario Donostia, San Sebastián, Spainen
dc.identifier.affiliationINEBA - Institute of Neuroscience Buenos Aires, Buenos Aires, Argentinaen
dc.identifier.affiliationJewish General Hospital, Montreal, QC, Canadaen
dc.identifier.affiliationJahn Ferenc Teaching Hospital, Budapest, Hungaryen
dc.identifier.affiliationNehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Beirut, Lebanonen
dc.identifier.affiliationHospital General Universitario de Alicante, Alicante, Spainen
dc.identifier.affiliationBombay Hospital Institute of Medical Sciences, Mumbai, Indiaen
dc.identifier.affiliationUniversidade Metropolitana de Santos, Santos, Brazilen
dc.identifier.affiliationSemmelweis University Budapest, Budapest, Hungaryen
dc.identifier.affiliationNeurology Department, King Fahad Specialist Hospital-Dammam, Dammam, Saudi Arabiaen
dc.identifier.affiliationHospital Universitario de la Ribera, Alzira, Spainen
dc.identifier.affiliationDepartment of Neurology, Faculty of Medicine, University of Debrecen, Debrecen, Hungaryen
dc.identifier.affiliationCentral Military Emergency University Hospital, Titu Maiorescu University, Bucharest, Romaniaen
dc.identifier.affiliationDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italyen
dc.identifier.affiliationDepartment of General Medicine, Parma University Hospital, Parma, Italyen
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/35582938/en
dc.identifier.doi10.1111/ene.15406en
dc.type.contentTexten
dc.identifier.orcidhttps://orcid.org/0000-0003-4818-3806en
dc.identifier.orcidhttps://orcid.org/0000-0002-3586-9115en
dc.identifier.orcidhttps://orcid.org/0000-0003-2885-9004en
dc.identifier.orcidhttps://orcid.org/0000-0002-6713-4623en
dc.identifier.orcidhttps://orcid.org/0000-0003-2634-8294en
dc.identifier.orcidhttps://orcid.org/0000-0002-0956-4633en
dc.identifier.orcidhttps://orcid.org/0000-0001-9615-3797en
dc.identifier.orcidhttps://orcid.org/0000-0001-9415-6177en
dc.identifier.orcidhttps://orcid.org/0000-0002-2540-6651en
dc.identifier.orcidhttps://orcid.org/0000-0001-8726-089Xen
dc.identifier.orcidhttps://orcid.org/0000-0003-3778-1376en
dc.identifier.pubmedid35582938-
local.name.researcherMacdonell, Richard A L
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptNeurology-
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