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Title: | The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments. | Austin Authors: | Venkatesh, Varun S ;Grossmann, Mathis ;Zajac, Jeffrey D ;Davey, Rachel A | Affiliation: | Medicine (University of Melbourne) Endocrinology |
Issue Date: | Jun-2022 | Date: | 2022-01-27 | Publication information: | Obesity Reviews 2022; 23(6): e13429 | Abstract: | Obesity is associated with hypothalamic-pituitary-testicular axis dysregulation in males. Here, we summarize recent evidence derived from clinical trials and studies in preclinical animal models regarding the role of androgen receptor (AR) signaling in the pathophysiology of males with obesity. We also discuss therapeutic strategies targeting the AR for the treatment of obesity and their limitations and provide insight into the future research necessary to advance this field. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/30169 | DOI: | 10.1111/obr.13429 | ORCID: | 0000-0002-1295-0033 0000-0001-8261-3457 0000-0003-3933-5708 0000-0001-5121-0209 |
Journal: | Obesity reviews : an official journal of the International Association for the Study of Obesity | PubMed URL: | 35083843 | PubMed URL: | https://pubmed.ncbi.nlm.nih.gov/35083843/ | Type: | Journal Article | Subjects: | fat men obesity testosterone |
Appears in Collections: | Journal articles |
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