Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/30105
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Bivard, Andrew | - |
dc.contributor.author | Zhao, Henry | - |
dc.contributor.author | Coote, Skye | - |
dc.contributor.author | Campbell, Bruce | - |
dc.contributor.author | Churilov, Leonid | - |
dc.contributor.author | Yassi, Nawaf | - |
dc.contributor.author | Yan, Bernard | - |
dc.contributor.author | Valente, Michael | - |
dc.contributor.author | Sharobeam, Angelos | - |
dc.contributor.author | Balabanski, Anna | - |
dc.contributor.author | Dos Santos, Angela | - |
dc.contributor.author | Ng, Felix C | - |
dc.contributor.author | Langenberg, Francesca | - |
dc.contributor.author | Stephenson, Michael | - |
dc.contributor.author | Smith, Karen | - |
dc.contributor.author | Bernard, Steve | - |
dc.contributor.author | Thijs, Vincent N | - |
dc.contributor.author | Cloud, Geoffrey | - |
dc.contributor.author | Choi, Philip | - |
dc.contributor.author | Ma, Henry | - |
dc.contributor.author | Wijeratne, Tissa | - |
dc.contributor.author | Chen, Chushuang | - |
dc.contributor.author | Olenko, Liudmyla | - |
dc.contributor.author | Davis, Stephen M | - |
dc.contributor.author | Donnan, Geoffrey A | - |
dc.contributor.author | Parsons, Mark | - |
dc.date | 2022 | - |
dc.date.accessioned | 2022-06-23T00:22:57Z | - |
dc.date.available | 2022-06-23T00:22:57Z | - |
dc.date.issued | 2022-04-29 | - |
dc.identifier.citation | BMJ open 2022; 12(4): e056573 | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/30105 | - |
dc.description.abstract | Mobile stroke units (MSUs) equipped with a CT scanner are increasingly being used to assess and treat stroke patients' prehospital with thrombolysis and transfer them to the most appropriate hospital for ongoing stroke care and thrombectomy when indicated. The effect of MSUs in both reducing the time to reperfusion treatment and improving patient outcomes is now established. There is now an opportunity to improve the efficacy of treatment provided by the MSU. Tenecteplase is a potent plasminogen activator, which may have benefits over the standard of care stroke lytic alteplase. Specifically, in the MSU environment tenecteplase presents practical benefits since it is given as a single bolus and does not require an infusion over an hour like alteplase. In this trial, we seek to investigate if tenecteplase, given to patients with acute ischaemic stroke as diagnosed on the MSU, improves the rate of early reperfusion. TASTE-A is a prospective, randomised, open-label, blinded endpoint (PROBE) phase II trial of patients who had an ischaemic stroke assessed in an MSU within 4.5 hours of symptom onset. The primary endpoint is early reperfusion measured by the post-lysis volume of the CT perfusion lesion performed immediately after hospital arrival. The study was approved by the Royal Melbourne Hospital Human Ethics committee. The findings will be published in peer-reviewed journals, presented at academic conferences and disseminated among consumer and healthcare professional audiences. NCT04071613. | en |
dc.language.iso | eng | |
dc.subject | Computed tomography | en |
dc.subject | Neurology | en |
dc.subject | STROKE MEDICINE | en |
dc.subject | Stroke | en |
dc.title | Tenecteplase versus Alteplase for Stroke Thrombolysis Evaluation Trial in the Ambulance (Mobile Stroke Unit-TASTE-A): protocol for a prospective randomised, open-label, blinded endpoint, phase II superiority trial of tenecteplase versus alteplase for ischaemic stroke patients presenting within 4.5 hours of symptom onset to the mobile stroke unit. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | BMJ open | en |
dc.identifier.affiliation | The Florey Institute of Neuroscience and Mental Health.. | en |
dc.identifier.affiliation | Neurology.. | en |
dc.identifier.affiliation | Melbourne Brain Centre at Royal Melbourne Hospital, Parkville, Victoria, Australia.. | en |
dc.identifier.affiliation | School of Medicine and Public Health, Department of Neurology Liverpool Hospital, University of New South Wales South Western Sydney Clinical School, Liverpool, New South Wales, Australia.. | en |
dc.identifier.affiliation | Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia.. | en |
dc.identifier.affiliation | Department of Medicine and Neurology, The University of Melbourne, Melbourne, Victoria, Australia.. | en |
dc.identifier.affiliation | Research and Evaluation, Ambulance Victoria, Doncaster, Victoria, Australia.. | en |
dc.identifier.affiliation | The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.. | en |
dc.identifier.affiliation | Department of Neurology, Western Health, Footscray, Victoria, Australia.. | en |
dc.identifier.affiliation | Department of Neurology, Monash University, Melbourne, Victoria, Australia.. | en |
dc.identifier.affiliation | Ambulance Victoria, Doncaster, Victoria, Australia.. | en |
dc.identifier.affiliation | Department of Neurology, Alfred Health, Monash University, Melbourne, Victoria, Australia.. | en |
dc.identifier.affiliation | Department of Neurology, Box Hill Hospital, Box Hill, Victoria, Australia.. | en |
dc.identifier.affiliation | Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.. | en |
dc.identifier.affiliation | Department of Neurology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.. | en |
dc.identifier.pubmeduri | https://pubmed.ncbi.nlm.nih.gov/35487712/ | en |
dc.identifier.doi | 10.1136/bmjopen-2021-056573 | en |
dc.type.content | Text | en |
dc.identifier.orcid | 0000-0002-4320-4287 | en |
dc.identifier.orcid | 0000-0001-6014-846X | en |
dc.identifier.orcid | 0000-0002-6614-8417 | en |
dc.identifier.pubmedid | 35487712 | |
local.name.researcher | Churilov, Leonid | |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Medicine (University of Melbourne) | - |
crisitem.author.dept | The Florey Institute of Neuroscience and Mental Health | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | The Florey Institute of Neuroscience and Mental Health | - |
crisitem.author.dept | The Florey Institute of Neuroscience and Mental Health | - |
Appears in Collections: | Journal articles |
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