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dc.contributor.authorPayne, Sophie C-
dc.contributor.authorWard, Glenn-
dc.contributor.authorFallon, James B-
dc.contributor.authorHyakumura, Tomoko-
dc.contributor.authorPrins, Johannes B-
dc.contributor.authorAndrikopoulos, Sofianos-
dc.contributor.authorMacIsaac, Richard J-
dc.contributor.authorVillalobos, Joel-
dc.identifier.citationPhysiological Reports 2022; 10(8): e15257en
dc.description.abstractVagus nerve stimulation is emerging as a promising treatment for type 2 diabetes. Here, we evaluated the ability of stimulation of the vagus nerve to reduce glycemia in awake, freely moving metabolically compromised rats. A model of type 2 diabetes (n = 10) was induced using a high-fat diet and low doses of streptozotocin. Stimulation of the abdominal vagus nerve was achieved by pairing 15 Hz pulses on a distal pair of electrodes with high-frequency blocking stimulation (26 kHz, 4 mA) on a proximal pair of electrodes to preferentially produce efferent conducting activity (eVNS). Stimulation was well tolerated in awake, freely moving rats. During 1 h of eVNS, glycemia decreased in 90% of subjects (-1.25 ± 1.25 mM h, p = 0.017), and 2 dB above neural threshold was established as the most effective "dose" of eVNS (p = 0.009). Following 5 weeks of implantation, eVNS was still effective, resulting in significantly decreased glycemia (-1.7 ± 0.6 mM h, p = 0.003) during 1 h of eVNS. There were no overt changes in fascicle area or signs of histopathological damage observed in implanted vagal nerve tissue following chronic implantation and stimulation. Demonstration of the biocompatibility and safety of eVNS in awake, metabolically compromised animals is a critical first step to establishing this therapy for clinical use. With further development, eVNS could be a promising novel therapy for treating type 2 diabetes.en
dc.subjectautonomic nervous systemen
dc.subjectbioelectric medicineen
dc.subjectdirectional stimulationen
dc.subjectmedical devicesen
dc.subjectmetabolic diseaseen
dc.subjectselective peripheral nerve stimulationen
dc.titleBlood glucose modulation and safety of efferent vagus nerve stimulation in a type 2 diabetic rat model.en
dc.typeJournal Articleen
dc.identifier.journaltitlePhysiological Reportsen
dc.identifier.affiliationMedicine (University of Melbourne)en
dc.identifier.affiliationDepartment of Endocrinology, Royal Melbourne Hospital, Parkville, Victoria, Australiaen
dc.identifier.affiliationAustralian Centre for Accelerating Diabetes Innovations, University of Melbourne, Melbourne, Australiaen
dc.identifier.affiliationBionics Institute, East Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medical Bionics, University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationDepartment of Endocrinology and Diabetes, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australiaen
dc.identifier.affiliationMelbourne Medical School, University of Melbourne, Parkville, Victoria, Australiaen
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item.openairetypeJournal Article-
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