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dc.contributor.authorLohinai, Zoltan-
dc.contributor.authorDora, David-
dc.contributor.authorCaldwell, Charles-
dc.contributor.authorRivard, Christopher J-
dc.contributor.authorSuda, Kenichi-
dc.contributor.authorYu, Hui-
dc.contributor.authorRivalland, Gareth-
dc.contributor.authorEllison, Kim-
dc.contributor.authorRozeboom, Leslie-
dc.contributor.authorDziadziuszko, Rafal-
dc.contributor.authorMitchell, Paul L R-
dc.contributor.authorJohn, Thomas-
dc.contributor.authorMillan, Inigo S-
dc.contributor.authorRen, Shengxiang-
dc.contributor.authorHirsch, Fred R-
dc.identifier.citationJournal of Surgical Oncology 2022; 125(6): 1042-1052en
dc.description.abstractStimulator of interferon (IFN) genes (STING) is a protein that promotes type I IFN production essential for T-cell activation. In this study, we aim to characterize STING expression comprehensively using The Cancer Genome Atlas (TCGA) database, cell lines, and patient tumor samples stained with immunohistochemistry. Two cohorts were evaluated comprising 721 non-small cell lung cancer (NSCLC) patients and 55 NSCLC cell lines for STING and cyclic GMP-AMP synthase (cGAS) expression using immunohistochemistry. Moreover, an independent cohort of n = 499 patients from the TCGA database was analyzed. Methylation was evaluated on STING and cGAS in five STING-negative NSCLC cell lines. STING RNA expression positively correlates with T cell function and development genes, negatively correlates with cell proliferation and associated with increased survival (5-year-overall survival [OS] 47.3% vs. 38.8%, p = 0.033). STING protein expression is significantly higher in adenocarcinoma (AC) and is lost with increasing stages of AC. STING-positivity is significantly higher in mutant EGFR and KRAS tumors. STING-positive NSCLC patients identified with immunohistochemistry (H-score > 50) have increased survival (median OS: 58 vs. 35 months, p = 0.02). Treatment of STING-negative cell lines with a demethylating agent restores STING expression. STING is ubiquitously expressed in NSCLC and associated with T cell function genes, AC histology, EGFR, and KRAS mutations and improved overall survival.en
dc.subjectT cell function genesen
dc.subjectnon-small cell lung cancer (NSCLC)en
dc.titleLoss of STING expression is prognostic in non-small cell lung cancer.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Surgical Oncologyen
dc.identifier.affiliationOlivia Newton-John Cancer Wellness and Research Centreen
dc.identifier.affiliationDepartment of Human Physiology and Nutrition, University of Colorado, Colorado Springs, Colorado, USAen
dc.identifier.affiliationDepartment of Anatomy, Histology, and Embryology, Faculty of Medicine, Semmelweis University, Budapest, Hungaryen
dc.identifier.affiliationDepartments of Medicine and Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USAen
dc.identifier.affiliationDivision of Thoracic Surgery, Department of Surgery, Faculty of Medicine, Kindai University, Osaka, Japanen
dc.identifier.affiliationDepartments of Medicine and Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USAen
dc.identifier.affiliationDepartment of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Polanden
dc.identifier.affiliationDepartment of Medicine, Metabolism, and Diabetes, University of Colorado School of Medicine, Aurora, CO, USAen
dc.identifier.affiliationDepartment of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, Chinaen
dc.identifier.affiliationTisch Cancer Institute, Center for Thoracic Oncology, Mount Sinai Health System, New York, New York, USAen
dc.identifier.affiliationNational Korányi Institute of Pulmonology, Budapest, Hungaryen
dc.identifier.pubmedid35099823-, Thomas
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristype Oncology- Newton-John Cancer Wellness and Research Centre- Newton-John Cancer Research Institute- Oncology- Newton-John Cancer Wellness and Research Centre-
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