Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/29676
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dc.contributor.authorConnolly, Elizabeth A-
dc.contributor.authorWeickhardt, Andrew J-
dc.contributor.authorGrimison, Peter-
dc.contributor.authorAsher, Rebecca-
dc.contributor.authorHeller, Gillian Z-
dc.contributor.authorLewin, Jeremy-
dc.contributor.authorLiow, Elizabeth-
dc.contributor.authorToner, Guy-
dc.contributor.authorTung, Iris L Y-
dc.contributor.authorTran, Ben-
dc.contributor.authorHill, Sean-
dc.contributor.authorWalpole, Euan-
dc.contributor.authorMcKenzie, Jane-
dc.contributor.authorKuchel, Anna-
dc.contributor.authorGoh, Jeffrey-
dc.contributor.authorForgeson, Garry-
dc.contributor.authorTan, Alvin-
dc.contributor.authorJoshi, Abhishek-
dc.contributor.authorWickham, Alistair-
dc.contributor.authorTan, Hsiang-
dc.contributor.authorWang, Yang-
dc.contributor.authorWinstanley, Mark A-
dc.contributor.authorHamad, Nada-
dc.contributor.authorWong, Vanessa-
dc.date2022-
dc.date.accessioned2022-04-05T04:55:45Z-
dc.date.available2022-04-05T04:55:45Z-
dc.date.issued2022-03-31-
dc.identifier.citationBJU international 2022; 130(1) Suppl: 5-16en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/29676-
dc.description.abstractTo report treatment patterns and survival outcomes of patients with relapsed and refractory metastatic germ cell tumours (GCTs) treated with high-dose chemotherapy (HDCT) and autologous stem-cell transplantation in low-volume specialized centres within the widely dispersed populations of Australia and New Zealand between 1999 and 2019. We conducted a retrospective analysis of 111 patients across 13 institutions. Patients were identified from the Australasian Bone Marrow Transplant Recipient Registry. We reviewed treatment regimens, survival outcomes, deliverability and toxicities. Primary endpoints included overall (OS) and progression-free survival (PFS). Cox proportional hazards models were used to test the association of survival outcomes with patient and treatment factors. The median (range) age was 30 (14-68) years and GCT histology was non-seminomatous in 84% of patients. International Prognostic Factors Study Group (IPFSG) prognostic risk category was very low/low, intermediate, high and very high in 18%, 36%, 25% and 21% of patients, respectively. Salvage conventional-dose chemotherapy (CDCT) was administered prior to HDCT in 59% of patients. Regimens included paclitaxel, ifosfamide, carboplatin and etoposide (50%), carboplatin and etoposide (CE; 28%), carboplatin, etoposide and ifosfamide (CEI; 6%), carboplatin, etoposide and cyclophosphamide (CEC; 5%), CEC-paclitaxel (6%) and other (5%). With a median follow-up of 4.4 years, the 1-, 2- and 5-year PFS rates were 62%, 57% and 52%, respectively, and OS rates were 73%, 65% and 61%, respectively. There were five treatment-related deaths. Progression on treatment occurred in 17%. In a univariable analysis, worse International Germ Cell Cancer Collaborative Group (IGCCCG) and IPFSG prognostic groups were associated with inferior survival outcomes. An association of inferior survival was not found with the number of high-dose cycles received nor when HDCT was delivered after salvage CDCT. This large dual-national registry-based study reinforces the efficacy and deliverability of HDCT for relapsed and refractory metastatic GCT in low-volume specialized centres in Australia and New Zealand, with survival outcomes comparable to those found in international practice.en
dc.language.isoeng-
dc.subjectsalvage therapyen
dc.subjecttesticular canceren
dc.titleHigh-dose chemotherapy for relapsed germ cell tumours: outcomes in low-volume specialized centres.en
dc.typeJournal Articleen
dc.identifier.journaltitleBJU internationalen
dc.identifier.affiliationWalter and Eliza Hall Institute of Medical Research, Melbourne, Australia..en
dc.identifier.affiliationPrincess Alexandra Hospital, Brisbane, Australia..en
dc.identifier.affiliationOlivia Newton-John Cancer Wellness and Research Centreen
dc.identifier.affiliationRoyal Brisbane and Women's Hospital and School of Medicine, University of Queensland, Brisbane, Australia..en
dc.identifier.affiliationTownsville University Hospital, James Cook University, Townsville, Australia..en
dc.identifier.affiliationRoyal Adelaide Hospital, Adelaide, Australia..en
dc.identifier.affiliationSt Vincent's Hospital, Melbourne, Australia..en
dc.identifier.affiliationAustralasian Bone Marrow Transplant Recipient Registry (ABMTRR), Sydney, Australia..en
dc.identifier.affiliationSt Vincent's Hospital Sydney, Sydney, Australia..en
dc.identifier.affiliationUniversity of New South Wales, Sydney, Australia..en
dc.identifier.affiliationChris O Brien Lifehouse, Sydney, Australia..en
dc.identifier.affiliationUniversity of Sydney, Sydney, Australia..en
dc.identifier.affiliationAustralian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP)..en
dc.identifier.affiliationNHMRC Clinical Trials Centre, Sydney, Sydney, Australia..en
dc.identifier.affiliationPeter MacCallum Cancer Centre, Melbourne, Australia..en
dc.identifier.affiliationRoyal Melbourne Hospital, Melbourne, Australia..en
dc.identifier.affiliationPalmerston North Hospital, Palmerston North, New Zealand..en
dc.identifier.affiliationWaikato Hospital, Hamilton, New Zealand..en
dc.identifier.affiliationAuckland City Hospital, Auckland, New Zealand..en
dc.identifier.affiliationStarship Children's Hospital, Auckland, New Zealand..en
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/35355402/en
dc.identifier.doi10.1111/bju.15648en
dc.type.contentTexten
dc.identifier.orcidhttps://orcid.org/0000-0002-5579-3728en
dc.identifier.orcidhttps://orcid.org/0000-0002-2653-1657en
dc.identifier.orcidhttps://orcid.org/0000-0002-4305-117Xen
dc.identifier.pubmedid35355402-
local.name.researcherWeickhardt, Andrew J
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
crisitem.author.deptMedical Oncology-
Appears in Collections:Journal articles
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