Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMooi, Jennifer K-
dc.contributor.authorChionh, Fiona-
dc.contributor.authorSavas, Peter-
dc.contributor.authorDa Gama Duarte, Jessica-
dc.contributor.authorChong, Geoffrey-
dc.contributor.authorBrown, Stephen-
dc.contributor.authorWong, Rachel-
dc.contributor.authorPrice, Timothy J-
dc.contributor.authorWann, Alysson-
dc.contributor.authorSkrinos, Effie-
dc.contributor.authorMariadason, John M-
dc.contributor.authorTebbutt, Niall C-
dc.identifier.citationClinical cancer research : an official journal of the American Association for Cancer Research 2021; 27(8): 2159-2167en
dc.description.abstractTo assess the efficacy and safety of dual antiangiogenesis agents, bevacizumab plus trebananib, without chemotherapy, in first-line treatment of metastatic colorectal cancer (mCRC). This open-label phase II study enrolled patients with unresectable mCRC with no prior systemic treatment. All patients received bevacizumab 7.5 mg/kg 3-weekly and trebananib 15 mg/kg weekly. The primary endpoint was disease control [stable disease, partial response (PR), or complete response (CR)] at 6 months (DC6m). Secondary endpoints included toxicity, overall response rate (ORR), progression-free survival (PFS), and overall survival (OS). Exploratory biomarkers in plasma angiogenesis-related proteins, tumor gene expression, and plasma antibodies to tumor antigens were examined. Forty-five patients were enrolled from four Australian sites. DC6m was 63% [95% confidence interval (CI), 47-77]. ORR was 17% (95% CI, 7-32), comprising of seven PRs. Median duration of response was 20 months (range, 10-48 months). Median PFS was 8.4 months and median OS 31.4 months. Grade 1-2 peripheral edema and joint-related symptoms were common. Overall incidence of grade 3-4 adverse events (AE) of any type was 33% (n = 15). Expected AEs of bevacizumab treatment did not appear to be increased by the addition of trebananib. In a first-line mCRC population, the dual antiangiogenic combination, bevacizumab plus trebananib, without chemotherapy, was efficacious with durable responses. The toxicity profile of the combination was manageable and did not exceed that expected with bevacizumab +/- chemotherapy. Exploratory biomarker results raise the hypothesis that the antiangiogenic combination may enable the antitumor immune response in immunotolerant colorectal cancer.en
dc.titleDual Antiangiogenesis Agents Bevacizumab Plus Trebananib, without Chemotherapy, in First-line Treatment of Metastatic Colorectal Cancer: Results of a Phase II Study.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical cancer research : an official journal of the American Association for Cancer Researchen
dc.identifier.affiliationPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia..en
dc.identifier.affiliationThe Queen Elizabeth Hospital, Adelaide, South Australia, Australia..en
dc.identifier.affiliationMonash University, Melbourne, Victoria, Australia..en
dc.identifier.affiliationEastern Health, Box Hill, Victoria, Australia..en
dc.identifier.affiliationBallarat Regional Integrated Cancer Centre, Ballarat, Victoria, Australia..en
dc.identifier.affiliationUniversity of Melbourne, Melbourne, Victoria, Australia..en
dc.identifier.affiliationLa Trobe University, Melbourne, Victoria, Australia..en
dc.identifier.affiliationAustin Healthen
dc.identifier.affiliationOlivia Newton-John Cancer Research Instituteen
dc.identifier.affiliationUniversity of Adelaide, Adelaide, South Australia, Australia..en
dc.identifier.affiliationUniversity of Melbourne, Melbourne, Victoria, Australia..en
dc.identifier.pubmedid33514526, Geoffrey
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristype Newton-John Cancer Research Institute- Newton-John Cancer Wellness and Research Centre- Newton-John Cancer Wellness and Research Centre- Newton-John Cancer Research Institute- Oncology- Newton-John Cancer Wellness and Research Centre-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

checked on Feb 29, 2024

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.