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dc.contributor.authorKong, Lingyun-
dc.contributor.authorAndrikopoulos, Sofianos-
dc.contributor.authorMacIsaac, Richard J-
dc.contributor.authorMackay, Laura K-
dc.contributor.authorNikolic-Paterson, David J-
dc.contributor.authorTorkamani, Niloufar-
dc.contributor.authorZafari, Neda-
dc.contributor.authorMarin, Evelyn C S-
dc.contributor.authorEkinci, Elif I-
dc.identifier.citationJournal of diabetes investigation 2022; 13(2): 213-226en
dc.description.abstractDiabetic kidney disease (DKD) is a highly prevalent complication of diabetes and the leading cause of end-stage kidney disease. Inflammation is recognized as an important driver of progression of DKD. Activation of the immune response promotes a pro-inflammatory milieu and subsequently renal fibrosis, and a progressive loss of renal function. Although the role of the innate immune system in diabetic renal disease has been well characterized, the potential contribution of the adaptive immune system remains poorly defined. Emerging evidence in experimental models of DKD indicates an increase in the number of T cells in the circulation and in the kidney cortex, that in turn triggers secretion of inflammatory mediators such as interferon-γ and tumor necrosis factor-α, and activation of cells in innate immune response. In human studies, the number of T cells residing in the interstitial region of the kidney correlates with the degree of albuminuria in people with type 2 diabetes. Here, we review the role of the adaptive immune system, and associated cytokines, in the development of DKD. Furthermore, the potential therapeutic benefits of targeting the adaptive immune system as a means of preventing the progression of DKD are discussed.en
dc.subjectAdaptive immune systemen
dc.subjectDiabetic kidney diseaseen
dc.titleRole of the adaptive immune system in diabetic kidney disease.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of diabetes investigationen
dc.identifier.affiliationDepartment of Endocrinology & Diabetes, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia..en
dc.identifier.affiliationCollege of Sport and Exercise Science, Victoria University, Melbourne, Victoria, Australia..en
dc.identifier.affiliationEndocrine Center of Excellence, Austin Health, Melbourne, Victoria, Australia..en
dc.identifier.affiliationDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia..en
dc.identifier.affiliationDepartment of Nephrology, Monash Medical Center and Monash University Center for Inflammatory Diseases, Melbourne, Victoria, Australia..en
dc.identifier.affiliationMedicine (University of Melbourne)en
dc.identifier.pubmedid34845863-, Elif I
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
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