Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/28854
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Vajda, Frank J E | - |
dc.contributor.author | O'Brien, Terence J | - |
dc.contributor.author | Graham, Janet E | - |
dc.contributor.author | Hitchcock, Alison E | - |
dc.contributor.author | Perucca, Piero | - |
dc.contributor.author | Lander, Cecilie M | - |
dc.contributor.author | Eadie, Mervyn J | - |
dc.date | 2022-02-14 | - |
dc.date.accessioned | 2022-02-22T04:30:39Z | - |
dc.date.available | 2022-02-22T04:30:39Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.citation | Epilepsy & Behavior 2022; 129: 108602 | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/28854 | - |
dc.description.abstract | To investigate possible factors that influenced whether pregnancy in women with epilepsy resulted in the desirable outcome of a live-born non-malformed infant and a mother whose pregnancy had been seizure free. The desirable outcome, as defined, occurred in 46.3% of unselected pregnancies in the database of the Australian Register of Antiepileptic Drugs in Pregnancy (APR). The only factor investigated that had a statistically significant (P < 0.05) effect, increasing the chance of such a desirable outcome, was freedom from seizures in the pre-pregnancy year. However, anti-seizure medication (ASM) doses, particularly valproate doses, had been reduced prior to 15.6% of the pregnancies, and this may have concealed factors that otherwise may have adversely affected the desirable outcome rate. Analysis of data for monotherapy with the more commonly used ASMs appears to suggest that employing levetiracetam at the outset of antiseizure therapy may offer a better chance of a desirable outcome to future pregnancies than monotherapy with other ASMs, but this finding is not confirmed statistically. In pregnancies where valproate use has already been minimized, seizure control throughout the pre-pregnancy year was associated with the best chance of a desirable outcome, as defined above. In most Australian women starting therapy for epilepsy initiating treatment with levetiracetam monotherapy may offer the best chance of such a desirable outcome to a future pregnancy, yet to be confirmed. | en |
dc.language.iso | eng | - |
dc.subject | Epilepsy | en |
dc.subject | Fetal malformation | en |
dc.subject | Levetiracetam | en |
dc.subject | Pregnancy | en |
dc.subject | Seizure control | en |
dc.subject | Valproate | en |
dc.title | Achieving neurologically desirable outcomes to pregnancy in women with epilepsy. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Epilepsy & Behavior : E&B | en |
dc.identifier.affiliation | Medicine (University of Melbourne) | en |
dc.identifier.affiliation | Comprehensive Epilepsy Program | en |
dc.identifier.affiliation | Department of Neurology, Alfred Health, Melbourne, VIC 3004, Australia | en |
dc.identifier.affiliation | Departments of Medicine and Neurosciences, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria 3050, Australia | en |
dc.identifier.affiliation | Department of Neuroscience, Monash University, Melbourne, VIC 3004, Australia | en |
dc.identifier.affiliation | Royal Brisbane and Women's Hospital and School of Medicine and Biomedical Science, University of Queensland, Brisbane, QLD 4027, Australia | en |
dc.identifier.pubmeduri | https://pubmed.ncbi.nlm.nih.gov/35176651/ | en |
dc.identifier.doi | 10.1016/j.yebeh.2022.108602 | en |
dc.type.content | Text | en |
dc.identifier.orcid | 0000-0002-7855-7066 | en |
dc.identifier.pubmedid | 35176651 | - |
local.name.researcher | Perucca, Piero | |
item.grantfulltext | none | - |
item.openairetype | Journal Article | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | Comprehensive Epilepsy Program | - |
Appears in Collections: | Journal articles |
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.