Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/28728
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dc.contributor.authorShepherd, Amy-
dc.contributor.authorLim, Jeremiah K H-
dc.contributor.authorWong, Vicky H Y-
dc.contributor.authorZeleznikow-Johnston, Ariel M-
dc.contributor.authorChurilov, Leonid-
dc.contributor.authorNguyen, Christine T O-
dc.contributor.authorBui, Bang V-
dc.contributor.authorHannan, Anthony J-
dc.contributor.authorBurrows, Emma L-
dc.date2021-08-12-
dc.date.accessioned2022-02-01T04:45:00Z-
dc.date.available2022-02-01T04:45:00Z-
dc.date.issued2021-12-
dc.identifier.citationNeurobiology of aging 2021; 108: 58-71en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/28728-
dc.description.abstractExecutive function deficits in Alzheimer's disease (AD) occur early in disease progression and may be predictive of cognitive decline. However, no preclinical studies have identified deficits in rewarded executive function in the commonly used APPSwe/PS1∆E9 (APP/PS1) mouse model. To address this, we assessed 12-26 month old APP/PS1 mice on rewarded reversal and/or extinction tasks. 16-month-old, but not 13- or 26-month-old, APP/PS1 mice showed an attenuated rate of extinction. Reversal deficits were seen in 22-month-old, but not 13-month-old APP/PS1 animals. We then confirmed that impairments in reversal were unrelated to previously reported visual impairments in both AD mouse models and humans. Age, but not genotype, had a significant effect on markers of retinal health, indicating the deficits seen in APP/PS1 mice were directly related to cognition. This is the first characterisation of rewarded executive function in APP/PS1 mice, and has great potential to facilitate translation from preclinical models to the clinic.en
dc.language.isoeng
dc.subjectAPP/PS1en
dc.subjectExecutive functionen
dc.subjectExtinctionen
dc.subjectMiceen
dc.subjectRodenten
dc.subjectTouchscreenen
dc.subjectVisual discriminationen
dc.titleProgressive impairments in executive function in the APP/PS1 model of Alzheimer's disease as measured by translatable touchscreen testing.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurobiology of agingen
dc.identifier.affiliationMedicine (University of Melbourne)..en
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health..en
dc.identifier.affiliationMelbourne Brain Centre, University of Melbourne, Parkville, Victoria, Australia..en
dc.identifier.affiliationMelbourne Brain Centre at Royal Melbourne Hospital, Melbourne Medical School, Parkville, Australia..en
dc.identifier.affiliationDepartment of Optometry and Vision Sciences, University of Melbourne, Victoria, Australia..en
dc.identifier.affiliationTurner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Victoria, Australia..en
dc.identifier.affiliationDepartment of Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria, Australia..en
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/34509856/en
dc.identifier.doi10.1016/j.neurobiolaging.2021.08.004en
dc.type.contentTexten
dc.identifier.orcid0000-0002-8929-5735en
dc.identifier.orcid0000-0002-9807-6606en
dc.identifier.orcid0000-0001-7532-8922en
dc.identifier.orcid0000-0002-6675-4679en
dc.identifier.orcid0000-0002-7497-8242en
dc.identifier.pubmedid34509856
local.name.researcherChurilov, Leonid
item.languageiso639-1en-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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