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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/28701
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dc.contributor.authorWang, Tingting-
dc.contributor.authorHuynh, Kevin-
dc.contributor.authorGiles, Corey-
dc.contributor.authorMellett, Natalie A-
dc.contributor.authorDuong, Thy-
dc.contributor.authorNguyen, Anh-
dc.contributor.authorLim, Wei Ling Florence-
dc.contributor.authorSmith, Alex At-
dc.contributor.authorOlshansky, Gavriel-
dc.contributor.authorCadby, Gemma-
dc.contributor.authorHung, Joseph-
dc.contributor.authorHui, Jennie-
dc.contributor.authorBeilby, John-
dc.contributor.authorWatts, Gerald F-
dc.contributor.authorChatterjee, Pratishtha-
dc.contributor.authorMartins, Ian-
dc.contributor.authorLaws, Simon M-
dc.contributor.authorBush, Ashley I-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorAmes, David-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorTaddei, Kevin-
dc.contributor.authorDoré, Vincent-
dc.contributor.authorFripp, Jürgen-
dc.contributor.authorArnold, Matthias-
dc.contributor.authorKastenmüller, Gabi-
dc.contributor.authorNho, Kwangsik-
dc.contributor.authorSaykin, Andrew J-
dc.contributor.authorBaillie, Rebecca-
dc.contributor.authorHan, Xianlin-
dc.contributor.authorMartins, Ralph N-
dc.contributor.authorMoses, Eric K-
dc.contributor.authorKaddurah-Daouk, Rima-
dc.contributor.authorMeikle, Peter J-
dc.date2022-
dc.date.accessioned2022-02-01T04:44:43Z-
dc.date.available2022-02-01T04:44:43Z-
dc.date.issued2022-01-25-
dc.identifier.citationAlzheimer's & Dementia: the Journal of the Alzheimer's Association 2022; 18(11)en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/28701-
dc.description.abstractThe apolipoprotein E (APOE) genotype is the strongest genetic risk factor for late-onset Alzheimer's disease. However, its effect on lipid metabolic pathways, and their mediating effect on disease risk, is poorly understood. We performed lipidomic analysis on three independent cohorts (the Australian Imaging, Biomarkers and Lifestyle [AIBL] flagship study, n = 1087; the Alzheimer's Disease Neuroimaging Initiative [ADNI] 1 study, n = 819; and the Busselton Health Study [BHS], n = 4384), and we defined associations between APOE ε2 and ε4 and 569 plasma/serum lipid species. Mediation analysis defined the proportion of the treatment effect of the APOE genotype mediated by plasma/serum lipid species. A total of 237 and 104 lipid species were associated with APOE ε2 and ε4, respectively. Of these 68 (ε2) and 24 (ε4) were associated with prevalent Alzheimer's disease. Individual lipid species or lipidomic models of APOE genotypes mediated up to 30% and 10% of APOE ε2 and ε4 treatment effect, respectively. Plasma lipid species mediate the treatment effect of APOE genotypes on Alzheimer's disease and as such represent a potential therapeutic target.en
dc.language.isoeng-
dc.subjectAPOE ε2en
dc.subjectAPOE ε4en
dc.subjectAlzheimer's diseaseen
dc.subjectlipid speciesen
dc.subjectlipidomicsen
dc.subjectmass spectrometryen
dc.titleAPOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies.en
dc.typeJournal Articleen
dc.identifier.journaltitleAlzheimer's & Dementia : The Journal of the Alzheimer's Associationen
dc.identifier.affiliationMolecular Imaging and Therapyen
dc.identifier.affiliationMedicine (University of Melbourne)en
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen
dc.identifier.affiliationCurtin Health Innovation Research Institute, Curtin University, Perth, Western Australiaen
dc.identifier.affiliationLipid Disorders Clinic, Department of Cardiology, Royal Perth Hospital, Perth, Western Australiaen
dc.identifier.affiliationMenzies Institute for Medical Research, University of Tasmania, Tasmania, Australiaen
dc.identifier.affiliationCSIRO Health and Biosecurity, Brisbane, Queensland, Australiaen
dc.identifier.affiliationDepartment of Biomedical Sciences, Macquarie University, North Ryde, New South Wales, Australiaen
dc.identifier.affiliationCentre for Precision Health, Edith Cowan University, Joondalup, Western Australiaen
dc.identifier.affiliationDepartment of Medicine, Duke University, Durham, North Carolina, USAen
dc.identifier.affiliationMedical School, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australiaen
dc.identifier.affiliationSchool of Population and Global Health, University of Western Australia, Perth, Western Australia, Australiaen
dc.identifier.affiliationDepartment of Molecular Imaging and Therapy, Austin Health, Melbourne, Victoria, Australiaen
dc.identifier.affiliationThe Australian e-Health Research Centre, Health and Biosecurity, CSIRO, Melbourne, Victoria, Australiaen
dc.identifier.affiliationSt George's Hospital, University of Melbourne Academic Unit for Psychiatry of Old Age, Kew, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USAen
dc.identifier.affiliationDuke Institute of Brain Sciences, Duke University, Durham, North Carolina, USAen
dc.identifier.affiliationPathWest Laboratory Medicine of Western Australia, Nedlands, Australiaen
dc.identifier.affiliationMonash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationKaRa Institute of Neurological Disease, Sydney, Macquarie Park, New South Wales, Australiaen
dc.identifier.affiliationBaker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationBaker Heart and Diabetes Institute, Melbourne, Victoria, Australiaen
dc.identifier.affiliationCollaborative Genomics Group, School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australiaen
dc.identifier.affiliationDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USAen
dc.identifier.affiliationRosa & Co LLC, San Carlos, California, USAen
dc.identifier.affiliationBarshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USAen
dc.identifier.affiliationDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USAen
dc.identifier.affiliationCenter for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, USAen
dc.identifier.affiliationIndiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USAen
dc.identifier.affiliationInstitute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germanyen
dc.identifier.affiliationNational Ageing Research Institute, Parkville, Victoria, Australiaen
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/35077012/en
dc.identifier.doi10.1002/alz.12538en
dc.type.contentTexten
dc.identifier.orcid0000-0001-8259-9069en
dc.identifier.orcid0000-0003-3072-7940en
dc.identifier.orcid0000-0003-3910-2453en
dc.identifier.orcid0000-0002-5832-9875en
dc.identifier.orcid0000-0002-8051-0558en
dc.identifier.pubmedid35077012-
local.name.researcherDoré, Vincent
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptMolecular Imaging and Therapy-
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