Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/28670
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dc.contributor.authorJalbrzikowski, Maria-
dc.contributor.authorHayes, Rebecca A-
dc.contributor.authorWood, Stephen J-
dc.contributor.authorNordholm, Dorte-
dc.contributor.authorZhou, Juan H-
dc.contributor.authorFusar-Poli, Paolo-
dc.contributor.authorUhlhaas, Peter J-
dc.contributor.authorTakahashi, Tsutomu-
dc.contributor.authorSugranyes, Gisela-
dc.contributor.authorKwak, Yoo Bin-
dc.contributor.authorMathalon, Daniel H-
dc.contributor.authorKatagiri, Naoyuki-
dc.contributor.authorHooker, Christine I-
dc.contributor.authorSmigielski, Lukasz-
dc.contributor.authorColibazzi, Tiziano-
dc.contributor.authorVia, Esther-
dc.contributor.authorTang, Jinsong-
dc.contributor.authorKoike, Shinsuke-
dc.contributor.authorRasser, Paul E-
dc.contributor.authorMichel, Chantal-
dc.contributor.authorLebedeva, Irina-
dc.contributor.authorHegelstad, Wenche Ten Velden-
dc.contributor.authorde la Fuente-Sandoval, Camilo-
dc.contributor.authorWaltz, James A-
dc.contributor.authorMizrahi, Romina-
dc.contributor.authorCorcoran, Cheryl M-
dc.contributor.authorResch, Franz-
dc.contributor.authorTamnes, Christian K-
dc.contributor.authorHaas, Shalaila S-
dc.contributor.authorLemmers-Jansen, Imke L J-
dc.contributor.authorAgartz, Ingrid-
dc.contributor.authorAllen, Paul-
dc.contributor.authorAmminger, G Paul-
dc.contributor.authorAndreassen, Ole A-
dc.contributor.authorAtkinson, Kimberley-
dc.contributor.authorBachman, Peter-
dc.contributor.authorBaeza, Inmaculada-
dc.contributor.authorBaldwin, Helen-
dc.contributor.authorBartholomeusz, Cali F-
dc.contributor.authorBorgwardt, Stefan-
dc.contributor.authorCatalano, Sabrina-
dc.contributor.authorChee, Michael W L-
dc.contributor.authorChen, Xiaogang-
dc.contributor.authorCho, Kang Ik K-
dc.contributor.authorCooper, Rebecca E-
dc.contributor.authorCropley, Vanessa L-
dc.contributor.authorDolz, Montserrat-
dc.contributor.authorEbdrup, Bjørn H-
dc.contributor.authorFortea, Adriana-
dc.contributor.authorGlenthøj, Louise Birkedal-
dc.contributor.authorGlenthøj, Birte Y-
dc.contributor.authorde Haan, Lieuwe-
dc.contributor.authorHamilton, Holly K-
dc.contributor.authorHarris, Mathew A-
dc.contributor.authorHaut, Kristen M-
dc.contributor.authorHe, Ying-
dc.contributor.authorHeekeren, Karsten-
dc.contributor.authorHeinz, Andreas-
dc.contributor.authorHubl, Daniela-
dc.contributor.authorHwang, Wu Jeong-
dc.contributor.authorKaess, Michael-
dc.contributor.authorKasai, Kiyoto-
dc.contributor.authorKim, Minah-
dc.contributor.authorKindler, Jochen-
dc.contributor.authorKlaunig, Mallory J-
dc.contributor.authorKoppel, Alex-
dc.contributor.authorKristensen, Tina D-
dc.contributor.authorKwon, Jun Soo-
dc.contributor.authorLawrie, Stephen M-
dc.contributor.authorLee, Jimmy-
dc.contributor.authorLeón-Ortiz, Pablo-
dc.contributor.authorLin, Ashleigh-
dc.contributor.authorLoewy, Rachel L-
dc.contributor.authorMa, Xiaoqian-
dc.contributor.authorMcGorry, Patrick-
dc.contributor.authorMcGuire, Philip-
dc.contributor.authorMizuno, Masafumi-
dc.contributor.authorMøller, Paul-
dc.contributor.authorMoncada-Habib, Tomas-
dc.contributor.authorMuñoz-Samons, Daniel-
dc.contributor.authorNelson, Barnaby-
dc.contributor.authorNemoto, Takahiro-
dc.contributor.authorNordentoft, Merete-
dc.contributor.authorOmelchenko, Maria A-
dc.contributor.authorOppedal, Ketil-
dc.contributor.authorOuyang, Lijun-
dc.contributor.authorPantelis, Christos-
dc.contributor.authorPariente, Jose C-
dc.contributor.authorRaghava, Jayachandra M-
dc.contributor.authorReyes-Madrigal, Francisco-
dc.contributor.authorRoach, Brian J-
dc.contributor.authorRøssberg, Jan I-
dc.contributor.authorRössler, Wulf-
dc.contributor.authorSalisbury, Dean F-
dc.contributor.authorSasabayashi, Daiki-
dc.contributor.authorSchall, Ulrich-
dc.contributor.authorSchiffman, Jason-
dc.contributor.authorSchlagenhauf, Florian-
dc.contributor.authorSchmidt, Andre-
dc.contributor.authorSørensen, Mikkel E-
dc.contributor.authorSuzuki, Michio-
dc.contributor.authorTheodoridou, Anastasia-
dc.contributor.authorTomyshev, Alexander S-
dc.contributor.authorTor, Jordina-
dc.contributor.authorVærnes, Tor G-
dc.contributor.authorVelakoulis, Dennis-
dc.contributor.authorVenegoni, Gloria D-
dc.contributor.authorVinogradov, Sophia-
dc.contributor.authorWenneberg, Christina-
dc.contributor.authorWestlye, Lars T-
dc.contributor.authorYamasue, Hidenori-
dc.contributor.authorYuan, Liu-
dc.contributor.authorYung, Alison R-
dc.contributor.authorvan Amelsvoort, Thérèse A M J-
dc.contributor.authorTurner, Jessica A-
dc.contributor.authorvan Erp, Theo G M-
dc.contributor.authorThompson, Paul M-
dc.contributor.authorHernaus, Dennis-
dc.date.accessioned2022-01-28T05:12:02Z-
dc.date.available2022-01-28T05:12:02Z-
dc.date.issued2021-07-01-
dc.identifier.citationJAMA Psychiatry 2021; 78(7): 753-766en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/28670-
dc.description.abstractThe ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological markers of psychosis risk. To investigate baseline structural neuroimaging differences between individuals at CHR and healthy controls as well as between participants at CHR who later developed a psychotic disorder (CHR-PS+) and those who did not (CHR-PS-). In this case-control study, baseline T1-weighted magnetic resonance imaging (MRI) data were pooled from 31 international sites participating in the ENIGMA Clinical High Risk for Psychosis Working Group. CHR status was assessed using the Comprehensive Assessment of At-Risk Mental States or Structured Interview for Prodromal Syndromes. MRI scans were processed using harmonized protocols and analyzed within a mega-analysis and meta-analysis framework from January to October 2020. Measures of regional cortical thickness (CT), surface area, and subcortical volumes were extracted from T1-weighted MRI scans. Independent variables were group (CHR group vs control group) and conversion status (CHR-PS+ group vs CHR-PS- group vs control group). Of the 3169 included participants, 1428 (45.1%) were female, and the mean (SD; range) age was 21.1 (4.9; 9.5-39.9) years. This study included 1792 individuals at CHR and 1377 healthy controls. Using longitudinal clinical information, 253 in the CHR-PS+ group, 1234 in the CHR-PS- group, and 305 at CHR without follow-up data were identified. Compared with healthy controls, individuals at CHR exhibited widespread lower CT measures (mean [range] Cohen d = -0.13 [-0.17 to -0.09]), but not surface area or subcortical volume. Lower CT measures in the fusiform, superior temporal, and paracentral regions were associated with psychosis conversion (mean Cohen d = -0.22; 95% CI, -0.35 to 0.10). Among healthy controls, compared with those in the CHR-PS+ group, age showed a stronger negative association with left fusiform CT measures (F = 9.8; P < .001; q < .001) and left paracentral CT measures (F = 5.9; P = .005; q = .02). Effect sizes representing lower CT associated with psychosis conversion resembled patterns of CT differences observed in ENIGMA studies of schizophrenia (ρ = 0.35; 95% CI, 0.12 to 0.55; P = .004) and individuals with 22q11.2 microdeletion syndrome and a psychotic disorder diagnosis (ρ = 0.43; 95% CI, 0.20 to 0.61; P = .001). This study provides evidence for widespread subtle, lower CT measures in individuals at CHR. The pattern of CT measure differences in those in the CHR-PS+ group was similar to those reported in other large-scale investigations of psychosis. Additionally, a subset of these regions displayed abnormal age associations. Widespread disruptions in CT coupled with abnormal age associations in those at CHR may point to disruptions in postnatal brain developmental processes.en
dc.language.isoeng
dc.titleAssociation of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group Mega-analysis.en
dc.typeJournal Articleen
dc.identifier.journaltitleJAMA Psychiatryen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen
dc.identifier.affiliationOrygen, Melbourne, Australiaen
dc.identifier.affiliationPriority Centre for Brain and Mental Health Research, The University of Newcastle, Newcastle, Australiaen
dc.identifier.affiliationPriority Research Centre for Stroke and Brain Injury, The University of Newcastle, Newcastle, Australiaen
dc.identifier.affiliationMelbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Melbourne, Australiaen
dc.identifier.affiliationCentre for Mental Health, Faculty of Health, Arts and Design, School of Health Sciences, Swinburne University, Melbourne, Australiaen
dc.identifier.affiliationTelethon Kids Institute, The University of Western Australia, Perth, Australiaen
dc.identifier.affiliationDepartment of Psychology, University of Oslo, Oslo, Norwayen
dc.identifier.affiliationPriority Research Centre Grow Up Well, The University of Newcastle, Newcastle, Australiaen
dc.identifier.affiliationNeuropsychiatry, The Royal Melbourne Hospital, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Psychiatry and Psychotherapy I, LVR-Hospital Cologne, Cologne, Germanyen
dc.identifier.affiliationDepartment of Child and Adolescent Psychiatry, Center of Psychosocial Medicine, University of Heidelberg, Heidelberg, Germanyen
dc.identifier.affiliationDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italyen
dc.identifier.affiliationEPIC Lab, Department of Psychosis Studies, King's College London, London, United Kingdomen
dc.identifier.affiliationDepartment of Clinical Physiology, Nuclear Medicine and PET, Functional Imaging Unit, University of Copenhagen, Glostrup, Denmarken
dc.identifier.affiliationDepartment of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germanyen
dc.identifier.affiliationInstitute of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdomen
dc.identifier.affiliationCenter for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singaporeen
dc.identifier.affiliationDepartment of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japanen
dc.identifier.affiliationResearch Center for Idling Brain Science, University of Toyama, Toyama, Japanen
dc.identifier.affiliationHunan Key Laboratory of Psychiatry and Mental Health, Changsha, Chinaen
dc.identifier.affiliationCenter for the Neurobiology of Learning and Memory, Irvine, Californiaen
dc.identifier.affiliationClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California, Irvineen
dc.identifier.affiliationDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, 2017SGR-881, Hospital Clinic Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Universitat de Barcelona, Barcelona, Spainen
dc.identifier.affiliationDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic Barcelona, Fundació Clínic Recerca Biomèdica, Universitat de Barcelona, Barcelona, Spainen
dc.identifier.affiliationMagnetic Resonance Imaging Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spainen
dc.identifier.affiliationChild and Adolescent Mental Health Research Group, Institut de Recerca Sant Joan de Déu, Barcelona, Spainen
dc.identifier.affiliationChild and Adolescent Psychiatry and Psychology Department, Hospital Sant Joan de Déu, Barcelona, Spainen
dc.identifier.affiliationDepartment of Child and Adolescent Psychiatry, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerlanden
dc.identifier.affiliationDepartment of Psychiatry, Columbia University, New York, New Yorken
dc.identifier.affiliationNew York State Psychiatric Institute, New Yorken
dc.identifier.affiliationDepartment of Psychiatry, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Chinaen
dc.identifier.affiliationKey Laboratory of Medical Neurobiology of Zhejiang Province, School of Medicine, Zhejiang University Hangzhou, Hangzhou, Chinaen
dc.identifier.affiliationDepartment of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norwayen
dc.identifier.affiliationPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norwayen
dc.identifier.affiliationDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Swedenen
dc.identifier.affiliationDepartment of Psychology, University of Roehampton, London, United Kingdomen
dc.identifier.affiliationNIHR Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust and King's College London, London, United Kingdomen
dc.identifier.affiliationNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Chinaen
dc.identifier.affiliationDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmarken
dc.identifier.affiliationDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japanen
dc.identifier.affiliationThe International Research Center for Neurointelligence at The University of Tokyo Institutes for Advanced Study, The University of Tokyo, Tokyo, Japanen
dc.identifier.affiliationDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Koreaen
dc.identifier.affiliationDepartment of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Koreaen
dc.identifier.affiliationCenter for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmarken
dc.identifier.affiliationDepartment of Psychosis, Institute of Mental Health, Singaporeen
dc.identifier.affiliationLee Kong Chian School of Medicine, Nanyang Technological University, Singaporeen
dc.identifier.affiliationDepartment of Psychology, University of Maryland, Baltimore County, Baltimoreen
dc.identifier.affiliationDepartment of Psychological Science, University of California, Irvineen
dc.identifier.affiliationEarly Intervention in Psychosis Advisory Unit for South-East Norway, TIPS Sør-Øst, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norwayen
dc.identifier.affiliationCentre for Youth Mental Health, University of Melbourne, Melbourne, Australiaen
dc.identifier.affiliationSchool of Psychology, University of Birmingham, Birmingham, United Kingdomen
dc.identifier.affiliationSchool of Health Sciences, University of Manchester, Manchester, United Kingdomen
dc.identifier.affiliationCenter for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, The University of Tokyo, Tokyo, Japanen
dc.identifier.affiliationThe University of Tokyo Institute for Diversity and Adaptation of Human Mind, Tokyo, Japanen
dc.identifier.affiliationFaculty of Social Sciences, University of Stavanger, Stavanger, Norwayen
dc.identifier.affiliationTIPS Centre for Clinical Research in Psychosis, Stavanger University Hospital, Stavanger, Norwayen
dc.identifier.affiliationDouglas Research Center, Montreal, Quebec, Canadaen
dc.identifier.affiliationMcGill University, Department of Psychiatry, Montreal, Quebec, Canadaen
dc.identifier.affiliationMental Illness Research, Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, New York, New Yorken
dc.identifier.affiliationDepartment of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germanyen
dc.identifier.affiliationDepartment of Psychiatry, Amsterdam University Medical Centre, Amsterdam, the Netherlandsen
dc.identifier.affiliationArkin, Amsterdam, the Netherlandsen
dc.identifier.affiliationSan Francisco Veterans Affairs Health Care System, San Francisco, Californiaen
dc.identifier.affiliationMaryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimoreen
dc.identifier.affiliationClinic for Child and Adolescent Psychiatry, University Hospital of Heidelberg, Heidelberg, Germanyen
dc.identifier.affiliationDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New Yorken
dc.identifier.affiliationFaculty of Behavioural and Movement Sciences, Department of Clinical, Neuro and Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlandsen
dc.identifier.affiliationCenter for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore, Singaporeen
dc.identifier.affiliationDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusettsen
dc.identifier.affiliationDepartment of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, Illinoisen
dc.identifier.affiliationTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerlanden
dc.identifier.affiliationDepartment of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Koreaen
dc.identifier.affiliationUniversity Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerlanden
dc.identifier.affiliationDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canadaen
dc.identifier.affiliationDivision of Psychiatry, University of Edinburgh, Edinburgh, United Kingdomen
dc.identifier.affiliationDepartment of Psychiatry and Behavioral Sciences, University of California, San Franciscoen
dc.identifier.affiliationNational Clinical Research Center for Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Chinaen
dc.identifier.affiliationDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdomen
dc.identifier.affiliationDepartment of Neuropsychiatry, Toho University School of Medicine, Tokyo, Japanen
dc.identifier.affiliationDepartment for Mental Health Research and Development, Division of Mental Health and Addiction, Vestre Viken Hospital Trust, Lier, Norwayen
dc.identifier.affiliationStavanger Medical Imaging Laboratory, Department of Radiology, Stavanger University Hospital, Stavanger, Norwayen
dc.identifier.affiliationLaboratory of Experimental Psychiatry, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexicoen
dc.identifier.affiliationNORMENT, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norwayen
dc.identifier.affiliationDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvaniaen
dc.identifier.affiliationDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin, Berlin, Germanyen
dc.identifier.affiliationDepartment of Psychiatry, University of Basel, Basel, Switzerlanden
dc.identifier.affiliationDepartment of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerlanden
dc.identifier.affiliationMental Health Research Center, Moscow, Russiaen
dc.identifier.affiliationDepartment of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolisen
dc.identifier.affiliationCopenhagen Research Center for Mental Health, Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmarken
dc.identifier.affiliationDepartment of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu City, Japanen
dc.identifier.affiliationDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlandsen
dc.identifier.affiliationDepartment of Psychology, Georgia State University, Atlantaen
dc.identifier.affiliationImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine of USC, University of Southern California, Los Angelesen
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/33950164/en
dc.identifier.doi10.1001/jamapsychiatry.2021.0638en
dc.type.contentTexten
dc.identifier.orcid0000-0002-9565-0238en
dc.identifier.pubmedid33950164
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
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