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https://ahro.austin.org.au/austinjspui/handle/1/28335| Title: | Characteristics of subjective cognitive decline associated with amyloid positivity. | Austin Authors: | Janssen, Olin;Jansen, Willemijn J;Vos, Stephanie J B;Boada, Merce;Parnetti, Lucilla;Gabryelewicz, Tomasz;Fladby, Tormod;Molinuevo, José Luis;Villeneuve, Sylvia;Hort, Jakub;Epelbaum, Stéphane;Lleó, Alberto;Engelborghs, Sebastiaan;van der Flier, Wiesje M;Landau, Susan;Popp, Julius;Wallin, Anders;Scheltens, Philip;Rikkert, Marcel Olde;Snyder, Peter J;Rowe, Christopher C ;Chételat, Gaël;Ruíz, Agustin;Marquié, Marta;Chipi, Elena;Wolfsgruber, Steffen;Heneka, Michael;Boecker, Henning;Peters, Oliver;Jarholm, Jonas;Rami, Lorena;Tort-Merino, Adrià;Binette, Alexa Pichet;Poirier, Judes;Rosa-Neto, Pedro;Cerman, Jiri;Dubois, Bruno;Teichmann, Marc;Alcolea, Daniel;Fortea, Juan;Sánchez-Saudinós, M Belén;Ebenau, Jarith;Pocnet, Cornelia;Eckerström, Marie;Thompson, Louisa;Villemagne, Victor L ;Buckley, Rachel;Burnham, Samantha;Delarue, Marion;Freund-Levi, Yvonne;Wallin, Åsa K;Ramakers, Inez;Tsolaki, Magda;Soininen, Hilkka;Hampel, Harald;Spiru, Luiza;Tijms, Betty;Ossenkoppele, Rik;Verhey, Frans R J;Jessen, Frank;Visser, Pieter Jelle | Affiliation: | Department of Clinical Sciences Malmö, Clinical Memory Research Unit, Lund University, Lund, Sweden.. Helen Wills Neuroscience Institute, University of California, Berkeley, California, USA.. Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA.. Kingston, The University of Rhode Island, Rhode Island, USA.. Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.. Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.. Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.. Brigham and Women's Hospital and Department of Neurology Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.. Functional Neuroimaging Group, Department of Radiology, University Hospital Bonn, Bonn, Germany.. Department of Neurodegenerative Diseases and Psychiatry, University Hospital Bonn, Bonn, Germany.. Section of Neurology, Center for Memory Disturbances - Lab. of Clinical Neurochemistry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.. Neurology Department, Hospital de Sant Pau, Barcelona, Spain.. Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic of Barcelona, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.. CSIRO Health & Biosecurity, Parkville, Victoria, Australia.. German Center For Neurodegenerative Diseases/Clinical Research, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE), Zentrum für klinische Forschung/AG, Cologne, Germany.. Molecular Imaging and Therapy Alzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.. AP-HP, Hôpital de la Pitié Salpêtrière, Institute of Memory and Alzheimer's Disease (IM2A), Centre of excellence of neurodegenerative disease (CoEN), Department of Neurology, Paris, France.. Inserm Sorbonne Université, Inria, Aramis project-team, Paris Brain Institute - Institut du Cerveau (ICM), Paris, France.. Department of Geriatric Psychiatry, Psychiatric University Hospital, Zürich, Switzerland.. Old Age Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.. Institute of Clinical Medicine, University of Oslo, Oslo, Norway.. Fundació ACE, Institut Català de Neurociències Aplicades, Facultat de Medicina, Universitat International de Catalunya-Barcelona, Barcelona, Spain.. Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.. International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic.. Carol DAVILA University of Medicine and Pharmacy, Bucharest, Romania.. Geriatrics- Gerontology and Old Age Psychiatry, Alzheimer Unit, Ana Aslan International Foundation - Memory Center and Longevity Medicine, Bucharest, Romania.. Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.. Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.. Department of Psychiatry, University of Cologne, Cologne, Germany.. Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.. Department of Neurology, Akershus University Hospital, Lorenskog, Norway.. Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre, Montreal, Quebec, Canada.. Vrije Universiteit Brussel, (VUB) Brussels, and University of Antwerp, Antwerp, Belgium.. Department of Geriatric Medicine, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands.. Institut National de la Sant. et de la Recherche M.dicale (Inserm), Caen, France.. Klinik für Psychiatrie und Psychotherapie, Charité Universitätsmedizin Berlin - CBF, Berlin, Deutschland.. Memory and Dementia Center, 3rd Department of Neurology, "G Papanicolau, " General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.. Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland.. GRC no 21, Alzheimer Precision Medicine (AMP), AP-HP, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.. |
Issue Date: | 2022 | Date: | 2021 | Publication information: | Alzheimer's & Dementia : the Journal of the Alzheimer's Association 2022; 18(10): 1832-1845 | Abstract: | The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity. Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE ε4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. Next to age, setting, and APOE ε4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/28335 | DOI: | 10.1002/alz.12512 | ORCID: | 0000-0002-5832-9875 0000-0003-3910-2453 |
Journal: | Alzheimer's & Dementia : The Journal of the Alzheimer's Association | PubMed URL: | 34877782 | PubMed URL: | https://pubmed.ncbi.nlm.nih.gov/34877782/ | Type: | Journal Article | Subjects: | Alzheimer's disease amyloid cerebrospinal fluid positron emission tomography subjective cognitive decline |
| Appears in Collections: | Journal articles |
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