Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/28117
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dc.contributor.authorBui, Dinh S-
dc.contributor.authorPerret, Jennifer L-
dc.contributor.authorWalters, E Haydn-
dc.contributor.authorAbramson, Michael J-
dc.contributor.authorBurgess, John A-
dc.contributor.authorBui, Minh Q-
dc.contributor.authorBowatte, Gayan-
dc.contributor.authorLowe, Adrian J-
dc.contributor.authorRussell, Melissa A-
dc.contributor.authorAlif, Sheikh M-
dc.contributor.authorThompson, Bruce R-
dc.contributor.authorHamilton, Garun S-
dc.contributor.authorGiles, Graham G-
dc.contributor.authorThomas, Paul S-
dc.contributor.authorMorrison, Stephen-
dc.contributor.authorJohns, David P-
dc.contributor.authorKnibbs, Luke D-
dc.contributor.authorZock, Jan-Paul-
dc.contributor.authorMarcon, Alessandro-
dc.contributor.authorGarcia-Aymerich, Judith-
dc.contributor.authorErbas, Bircan-
dc.contributor.authorJarvis, Deborah-
dc.contributor.authorSvanes, Cecilie-
dc.contributor.authorLodge, Caroline J-
dc.contributor.authorDharmage, Shyamali C-
dc.date.accessioned2021-11-24T05:40:04Z-
dc.date.available2021-11-24T05:40:04Z-
dc.date.issued2020-03-
dc.identifier.citationAnnals of the American Thoracic Society 2020; 17(3): 302-312.en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/28117-
dc.description.abstractRationale: Interactions between early life and adult insults on lung function decline are not well understood, with most studies investigating prebronchodilator (pre-BD) FEV1 decline.Objectives: To investigate relationships between adult risk factors and pre- and post-BD lung function decline and their potential effect modification by early life and genetic factors.Methods: Multiple regression was used to examine associations between adult exposures (asthma, smoking, occupational exposures, traffic pollution, and obesity) and decline in both pre- and post-BD spirometry (forced expiratory volume in 1 s [FEV1], forced vital capacity [FVC], and FEV1/FVC) between ages 45 and 53 years in the Tasmanian Longitudinal Health Study (n = 857). Effect modification of these relationships by childhood respiratory risk factors, including low childhood lung function and GST (glutathione S-transferase) gene polymorphisms, was investigated.Results: Baseline asthma, smoking, occupational exposure to vapors/gases/dusts/fumes, and living close to traffic were associated with accelerated decline in both pre- and post-BD FEV1. These factors were also associated with FEV1/FVC decline. Occupational exposure to aromatic solvents was associated with pre-BD but not post-BD FEV1 decline. Maternal smoking accentuated the effect of personal smoking on pre- and post-BD FEV1 decline. Lower childhood lung function and having the GSTM1 null allele accentuated the effect of occupational exposure to vapors/gases/dusts/fumes and personal smoking on post-BD FEV1 decline. Incident obesity was associated with accelerated decline in FEV1 and more pronounced in FVC.Conclusions: This study provides new evidence for accentuation of individual susceptibility to adult risk factors by low childhood lung function, GSTM1 genotype, and maternal smoking.en
dc.language.isoeng
dc.subjectbronchodilatoren
dc.subjectdeclineen
dc.subjectinteractionen
dc.subjectlung functionen
dc.subjectsusceptibilityen
dc.titleLifetime Risk Factors for Pre- and Post-Bronchodilator Lung Function Decline. A Population-based Study.en
dc.typeJournal Articleen
dc.identifier.journaltitleAnnals of the American Thoracic Societyen
dc.identifier.affiliationInstitute for Breathing and Sleep..en
dc.identifier.affiliationUniversity of Queensland, Brisbane, Queensland, Australia..en
dc.identifier.affiliationDepartment of Respiratory Medicine, School of Medicine, Flinders University, Adelaide, South Australia, Australia..en
dc.identifier.affiliationSchool of Public Health, the University of Queensland, Brisbane, Queensland, Australia..en
dc.identifier.affiliationSchool of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia..en
dc.identifier.affiliationRespiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, United Kingdom..en
dc.identifier.affiliationUnit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy..en
dc.identifier.affiliationAllergy and Lung Health Unit, The University of Melbourne, Melbourne, Victoria, Australia..en
dc.identifier.affiliationDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health..en
dc.identifier.affiliationCentre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway..en
dc.identifier.affiliationDepartment of Occupational Medicine, Haukeland University Hospital, Bergen, Norway..en
dc.identifier.affiliationDepartment of Analytical Chemistry and Toxicology, Hanoi University of Pharmacy, Hanoi, Vietnam..en
dc.identifier.affiliationSchool of Clinical Sciences, Monash Health, Melbourne, Victoria, Australia..en
dc.identifier.affiliationMonash Lung and Sleep, Monash Health, Melbourne, Victoria, Australia..en
dc.identifier.affiliationPrecision Medicine, School of Clinical Sciences at Monash Health, Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia..en
dc.identifier.affiliationCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia..en
dc.identifier.affiliationPrince of Wales Hospital Clinical School and School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia..en
dc.identifier.affiliationISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain..en
dc.identifier.affiliationUniversitat Pompeu Fabra (UPF), Barcelona, Spain..en
dc.identifier.affiliationCentral Clinical School, Monash University, Melbourne, Victoria, Australia..en
dc.identifier.affiliationAllergy, Immunology, and Respiratory Medicine, The Alfred Hospital, Melbourne, Victoria, Australia..en
dc.identifier.affiliationSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia...en
dc.identifier.affiliationCIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain..en
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/31800292/en
dc.identifier.doi10.1513/AnnalsATS.201904-329OCen
dc.type.contentTexten
dc.identifier.orcid0000-0002-4388-784Xen
dc.identifier.orcid0000-0002-7097-4586en
dc.identifier.orcid0000-0001-6063-1937en
dc.identifier.orcid0000-0001-7034-0615en
dc.identifier.pubmedid31800292
local.name.researcherPerret, Jennifer L
item.languageiso639-1en-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
crisitem.author.deptInstitute for Breathing and Sleep-
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