Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/28095
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTan, Daniel J-
dc.contributor.authorLodge, Caroline J-
dc.contributor.authorLowe, Adrian J-
dc.contributor.authorBui, Dinh S-
dc.contributor.authorBowatte, Gayan-
dc.contributor.authorJohns, David P-
dc.contributor.authorHamilton, Garun S-
dc.contributor.authorThomas, Paul S-
dc.contributor.authorAbramson, Michael J-
dc.contributor.authorWalters, E Haydn-
dc.contributor.authorPerret, Jennifer L-
dc.contributor.authorDharmage, Shyamali C-
dc.date2021-01-
dc.date.accessioned2021-11-24T05:39:51Z-
dc.date.available2021-11-24T05:39:51Z-
dc.date.issued2021-02-08-
dc.identifier.citationERJ open research 2021; 7(1): 00042-2020en
dc.identifier.issn2312-0541-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/28095-
dc.description.abstractBronchodilator reversibility (BDR) is often used as a diagnostic test for adult asthma. However, there has been limited assessment of its diagnostic utility. We aimed to determine the discriminatory accuracy of common BDR cut-offs in the context of current asthma and asthma-COPD overlap (ACO) in a middle-aged community sample. The Tasmanian Longitudinal Health Study is a population-based cohort first studied in 1968 (n=8583). In 2012, participants completed respiratory questionnaires and spirometry (n=3609; mean age 53 years). Receiver operating characteristic (ROC) curves were fitted for current asthma and ACO using continuous BDR measurements. Diagnostic parameters were calculated for different categorical cut-offs. Area under the ROC curve (AUC) was highest when BDR was expressed as change in forced expiratory volume in 1 s (FEV1) as a percentage of initial FEV1, as compared with predicted FEV1. The corresponding AUC was 59% (95% CI 54-64%) for current asthma and 87% (95% CI 81-93%) for ACO. Of the categorical cut-offs examined, the European Respiratory Society/American Thoracic Society threshold (≥12% from baseline and ≥200 mL) was assessed as providing the best balance between positive and negative likelihood ratios (LR+ and LR-, respectively), with corresponding sensitivities and specificities of 9% and 97%, respectively, for current asthma (LR+ 3.26, LR- 0.93), and 47% and 97%, respectively, for ACO (LR+ 16.05, LR- 0.55). With a threshold of ≥12% and ≥200 mL from baseline, a positive BDR test provided a clinically meaningful change in the post-test probability of disease, whereas a negative test did not. BDR was more useful as a diagnostic test in those with co-existent post-bronchodilator airflow obstruction (ACO).en
dc.language.isoeng-
dc.titleBronchodilator reversibility as a diagnostic test for adult asthma: findings from the population-based Tasmanian Longitudinal Health Study.en
dc.typeJournal Articleen
dc.identifier.journaltitleERJ open researchen
dc.identifier.affiliationInstitute for Breathing and Sleepen
dc.identifier.affiliationSchool of Public Health & Preventive Medicine, Monash University, Melbourne, Victoria, Australia..en
dc.identifier.affiliationSchool of Medicine, University of Tasmania, Hobart, Tasmania, Australia..en
dc.identifier.affiliationMonash Lung and Sleep, Monash Health, Clayton, Victoria, Australia..en
dc.identifier.affiliationSchool of Clinical Sciences, Monash University, Clayton, Victoria, Australia..en
dc.identifier.affiliationAllergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia..en
dc.identifier.affiliationDept of Basic Sciences, Faculty of Allied Health Sciences, University of Peradeniya, Peradeniya, Sri Lanka..en
dc.identifier.affiliationNational Institute of Fundamental Studies, Kandy, Sri Lanka..en
dc.identifier.affiliationPrince of Wales' Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia..en
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/33585659/en
dc.identifier.doi10.1183/23120541.00042-2020en
dc.type.contentTexten
dc.identifier.orcid0000-0002-9954-0538en
dc.identifier.orcid0000-0001-7034-0615en
dc.identifier.pubmedid33585659-
local.name.researcherPerret, Jennifer L
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptInstitute for Breathing and Sleep-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

18
checked on Nov 22, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.