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DC Field | Value | Language |
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dc.contributor.author | Tan, Daniel J | - |
dc.contributor.author | Lodge, Caroline J | - |
dc.contributor.author | Lowe, Adrian J | - |
dc.contributor.author | Bui, Dinh S | - |
dc.contributor.author | Bowatte, Gayan | - |
dc.contributor.author | Johns, David P | - |
dc.contributor.author | Hamilton, Garun S | - |
dc.contributor.author | Thomas, Paul S | - |
dc.contributor.author | Abramson, Michael J | - |
dc.contributor.author | Walters, E Haydn | - |
dc.contributor.author | Perret, Jennifer L | - |
dc.contributor.author | Dharmage, Shyamali C | - |
dc.date | 2021-01 | - |
dc.date.accessioned | 2021-11-24T05:39:51Z | - |
dc.date.available | 2021-11-24T05:39:51Z | - |
dc.date.issued | 2021-02-08 | - |
dc.identifier.citation | ERJ open research 2021; 7(1): 00042-2020 | en |
dc.identifier.issn | 2312-0541 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/28095 | - |
dc.description.abstract | Bronchodilator reversibility (BDR) is often used as a diagnostic test for adult asthma. However, there has been limited assessment of its diagnostic utility. We aimed to determine the discriminatory accuracy of common BDR cut-offs in the context of current asthma and asthma-COPD overlap (ACO) in a middle-aged community sample. The Tasmanian Longitudinal Health Study is a population-based cohort first studied in 1968 (n=8583). In 2012, participants completed respiratory questionnaires and spirometry (n=3609; mean age 53 years). Receiver operating characteristic (ROC) curves were fitted for current asthma and ACO using continuous BDR measurements. Diagnostic parameters were calculated for different categorical cut-offs. Area under the ROC curve (AUC) was highest when BDR was expressed as change in forced expiratory volume in 1 s (FEV1) as a percentage of initial FEV1, as compared with predicted FEV1. The corresponding AUC was 59% (95% CI 54-64%) for current asthma and 87% (95% CI 81-93%) for ACO. Of the categorical cut-offs examined, the European Respiratory Society/American Thoracic Society threshold (≥12% from baseline and ≥200 mL) was assessed as providing the best balance between positive and negative likelihood ratios (LR+ and LR-, respectively), with corresponding sensitivities and specificities of 9% and 97%, respectively, for current asthma (LR+ 3.26, LR- 0.93), and 47% and 97%, respectively, for ACO (LR+ 16.05, LR- 0.55). With a threshold of ≥12% and ≥200 mL from baseline, a positive BDR test provided a clinically meaningful change in the post-test probability of disease, whereas a negative test did not. BDR was more useful as a diagnostic test in those with co-existent post-bronchodilator airflow obstruction (ACO). | en |
dc.language.iso | eng | - |
dc.title | Bronchodilator reversibility as a diagnostic test for adult asthma: findings from the population-based Tasmanian Longitudinal Health Study. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | ERJ open research | en |
dc.identifier.affiliation | Institute for Breathing and Sleep | en |
dc.identifier.affiliation | School of Public Health & Preventive Medicine, Monash University, Melbourne, Victoria, Australia.. | en |
dc.identifier.affiliation | School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.. | en |
dc.identifier.affiliation | Monash Lung and Sleep, Monash Health, Clayton, Victoria, Australia.. | en |
dc.identifier.affiliation | School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.. | en |
dc.identifier.affiliation | Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.. | en |
dc.identifier.affiliation | Dept of Basic Sciences, Faculty of Allied Health Sciences, University of Peradeniya, Peradeniya, Sri Lanka.. | en |
dc.identifier.affiliation | National Institute of Fundamental Studies, Kandy, Sri Lanka.. | en |
dc.identifier.affiliation | Prince of Wales' Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia.. | en |
dc.identifier.pubmeduri | https://pubmed.ncbi.nlm.nih.gov/33585659/ | en |
dc.identifier.doi | 10.1183/23120541.00042-2020 | en |
dc.type.content | Text | en |
dc.identifier.orcid | 0000-0002-9954-0538 | en |
dc.identifier.orcid | 0000-0001-7034-0615 | en |
dc.identifier.pubmedid | 33585659 | - |
local.name.researcher | Perret, Jennifer L | |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
Appears in Collections: | Journal articles |
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