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Title: Human epididymis protein 4: a novel predictor of ischemic cardiomyopathy.
Austin Authors: Tang, Yi;Wang, Yinzhen;Xu, Xiaoping;Tu, Laura Yan;Huang, Pei;Yang, Xiaoyan;Li, Lihua;Wu, Juan;Zhang, Yan;Fu, Qinghua;Yu, Yingli;Zheng, Zhaofen;Song, Lixia;Zhang, Yi
Affiliation: General Medicine
Department of Cardiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal University, Changsha, 410005, China
Department of Gastroenterology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Hunan Normal University, Changsha, 410005, China
Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China
Issue Date: 2021
Date: 2021-10-21
Publication information: BMC cardiovascular disorders 2021; 21(1): 511
Abstract: The prognostic value of human epididymis protein 4 (HE4) in patients with ischemic cardiomyopathy (ICM) is unknown. A total of 103 patients with ICM were prospectively enrolled in this study from Hunan Provincial People's Hospital between February 2019 and June 2019. All patients were tested for HE4 levels at baseline and follow-up. Endpoints of the study included cardiovascular death and heart failure-related hospitalization. A total of 96 patients with ICM were included for analysis. After a mean follow-up period of 263 (153-313) days, cardiovascular events were observed in 45 patients. Serum HE4 levels in patients with events were significantly higher than those in patients without events [188.70 (113.35-326.82) pmol/L versus 92.90 (61.50-123.20) pmol/L, P < 0.001]. Multivariate Cox regression analysis revealed that HE4 [χ2: 9.602, hazard ratio (HR): 1.003, 95% confidence interval (CI): 1.001-1.005, P = 0.002] and age [χ2: 4.55, HR: 1.044, 95% CI: 1.003-1.085, P = 0.033] were independent predictors of events. After adjusting for age and sex, the risk of events in patients with HE4 > 100.2 pmol/L was higher than that in patients with HE4 ≤ 100.2 pmol/L [HR: 3.372, 95% CI: 1.409-8.065, P < 0.001]. HE4 is an independent predictor of cardiovascular death and heart failure-related rehospitalization in patients with ICM.
DOI: 10.1186/s12872-021-02319-5
Journal: BMC Cardiovascular Disorders
PubMed URL: 34674652
Type: Journal Article
Subjects: Human epididymis protein 4
Ischemic cardiomyopathy
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