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dc.contributor.authorO'Donnell, David-
dc.contributor.authorWisnoskey, Brian-
dc.contributor.authorBadie, Nima-
dc.contributor.authorOdgers, Lisa-
dc.contributor.authorSmart, Taylah-
dc.contributor.authorOrd, Michelle-
dc.contributor.authorLin, Tina-
dc.contributor.authorMangual, Jan O-
dc.contributor.authorCranke, Gary-
dc.contributor.authorMcSpadden, Luke C-
dc.contributor.authorRyu, Kyungmoo-
dc.contributor.authorBianchi, Valter-
dc.contributor.authorD'Onofrio, Antonio-
dc.contributor.authorPappone, Carlo-
dc.contributor.authorCalò, Leonardo-
dc.contributor.authorChow, Anthony-
dc.contributor.authorBetts, Tim R-
dc.contributor.authorThibault, Bernard-
dc.contributor.authorVarma, Niraj-
dc.identifier.citationJournal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing 2021; 61(3): 453-460en
dc.description.abstractMultipoint pacing (MPP) improves left ventricular (LV) electrical synchrony in cardiac resynchronization therapy (CRT). SyncAV automatically adjusts atrioventricular delay (AVD) according to intrinsic AV intervals and may further improve synchrony. Their combination has not been assessed. The objective was to evaluate the improvement in electrical synchrony achieved by SyncAV combined with MPP in an international, multicenter study. Patients with LBBB undergoing CRT implant with a quadripolar lead (Abbott Quartet™) were prospectively enrolled. QRS duration (QRSd) was measured by blinded observers from 12-lead ECG during: intrinsic conduction, BiV pacing (conventional biventricular pacing, nominal static AVD), MPP (2 LV cathodes maximally spaced, nominal static AVD), BiV + SyncAV, and MPP + SyncAV. All SyncAV offsets were individualized for each patient to yield the narrowest QRSd during BiV pacing. QRSd changes were compared by ANOVA and post hoc Tukey-Kramer tests. One hundred and three patients were enrolled (65.7 ± 12.1 years, 67% male, 37% ischemic, EF 26.4 ± 6.5%, PR 190.3 ± 39.1 ms). Relative to intrinsic conduction (QRSd of 165 ± 16 ms), BiV reduced QRSd by 11.9% to 145 ± 18 ms (P < 0.001 vs intrinsic), and MPP reduced QRSd by 13.3% to 142 ± 19 ms (P < 0.001 vs intrinsic). However, enabling SyncAV with a patient-optimized offset nearly doubled this QRSd reduction. BiV + SyncAV reduced QRSd by 22.0% to 128 ± 13 ms (P < 0.001 vs BiV), while MPP + SyncAV reduced QRSd further by 25.6% to 122 ± 14 ms (P < 0.05 vs BiV + SyncAV). SyncAV can significantly improve acute electrical synchrony beyond conventional CRT, with further improvement achieved by superimposing MPP.en
dc.subjectAtrioventricular delayen
dc.subjectCardiac resynchronization therapyen
dc.subjectHeart failureen
dc.subjectMultipoint pacingen
dc.subjectQRS durationen
dc.titleElectrical synchronization achieved by multipoint pacing combined with dynamic atrioventricular delay.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacingen
dc.identifier.affiliationGenesisCare Cardiology, Burgundy Street, Heidelberg, Victoria, 3084, Australiaen
dc.identifier.affiliationAbbott, Cleveland, OH, USA..en
dc.identifier.affiliationAbbott, Sylmar, CA, USA..en
dc.identifier.affiliationAbbott, Cleveland, OH, USA..en
dc.identifier.affiliationAbbott, Sylmar, CA, USA..en
dc.identifier.affiliationDepartment of Cardiology, Monaldi Hospital, Naples, Italy..en
dc.identifier.affiliationDepartment of Arrhythmology, I.R.C.C.S. Policlinico San Donato, San Donato Milanese, Italy..en
dc.identifier.affiliationPoliclinico Casilino, Rome, Italy..en
dc.identifier.affiliationBarts Heart Centre, St. Bartholomew's Hospital, London, UK..en
dc.identifier.affiliationCardiology Department, Oxford University Hospital, Oxford, UK..en
dc.identifier.affiliationMontreal Heart Institute, Montreal, Canada..en
dc.identifier.affiliationCleveland Clinic, Cleveland, OH, USA..en
dc.identifier.pubmedid32740689'Donnell, David
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
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