Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/26989
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dc.contributor.authorBerthelet, Jean-
dc.contributor.authorWimmer, Verena C-
dc.contributor.authorWhitfield, Holly J-
dc.contributor.authorSerrano, Antonin-
dc.contributor.authorBoudier, Thomas-
dc.contributor.authorMangiola, Stefano-
dc.contributor.authorMerdas, Michal-
dc.contributor.authorEl-Saafin, Farrah-
dc.contributor.authorBaloyan, David-
dc.contributor.authorWilcox, Jordan-
dc.contributor.authorWilcox, Steven-
dc.contributor.authorParslow, Adam C-
dc.contributor.authorPapenfuss, Anthony T-
dc.contributor.authorYeo, Belinda-
dc.contributor.authorErnst, Matthias-
dc.contributor.authorPal, Bhupinder-
dc.contributor.authorAnderson, Robin L-
dc.contributor.authorDavis, Melissa J-
dc.contributor.authorRogers, Kelly L-
dc.contributor.authorHollande, Frédéric-
dc.contributor.authorMerino, Delphine-
dc.date2021-07-07-
dc.date.accessioned2021-07-12T06:10:10Z-
dc.date.available2021-07-12T06:10:10Z-
dc.date.issued2021-
dc.identifier.citationScience advances 2021; 7(28)en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/26989-
dc.description.abstractIntratumoral heterogeneity is a driver of breast cancer progression, but the nature of the clonal interactive network involved in this process remains unclear. Here, we optimized the use of optical barcoding to visualize and characterize 31 cancer subclones in vivo. By mapping the clonal composition of thousands of metastases in two clinically relevant sites, the lungs and liver, we found that metastases were highly polyclonal in lungs but not in the liver. Furthermore, the transcriptome of the subclones varied according to their metastatic niche. We also identified a reversible niche-driven signature that was conserved in lung and liver metastases collected during patient autopsies. Among this signature, we found that the tumor necrosis factor-α pathway was up-regulated in lung compared to liver metastases, and inhibition of this pathway affected metastasis diversity. These results highlight that the cellular and molecular heterogeneity observed in metastases is largely dictated by the tumor microenvironment.en
dc.language.isoeng-
dc.titleThe site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile.en
dc.typeJournal Articleen
dc.identifier.journaltitleScience Advancesen
dc.identifier.affiliationImmunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australiaen
dc.identifier.affiliationDepartment of Medical Biology, Faculty of Medicine, Dentistry, and Health Science, The University of Melbourne, Parkville, VIC 3010, Australiaen
dc.identifier.affiliationBioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australiaen
dc.identifier.affiliationPeter MacCallum Cancer Centre, Melbourne, VIC 3000, Australiaen
dc.identifier.affiliationSir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC 3000, Australiaen
dc.identifier.affiliationOlivia Newton-John Cancer Research Instituteen
dc.identifier.affiliationSchool of Cancer Medicine, La Trobe University, Bundoora, VIC 3086, Australiaen
dc.identifier.affiliationAustin Healthen
dc.identifier.affiliationDepartment of Clinical Pathology, Faculty of Medicine, Dentistry, and Health Science, The University of Melbourne, Melbourne, VIC 3000, Australiaen
dc.identifier.affiliationAdvanced Technology and Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australiaen
dc.identifier.affiliationUniversity of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, VIC 3000, Australiaen
dc.identifier.doi10.1126/sciadv.abf4408en
dc.type.contentTexten
dc.identifier.orcid0000-0003-2562-0575en
dc.identifier.orcid0000-0002-9931-8179en
dc.identifier.orcid0000-0002-7282-387Xen
dc.identifier.orcid0000-0002-8178-6441en
dc.identifier.orcid0000-0002-0148-7733en
dc.identifier.orcid0000-0001-7474-836Xen
dc.identifier.orcid0000-0003-3257-9953en
dc.identifier.orcid0000-0002-1650-8007en
dc.identifier.orcid0000-0002-0585-9573en
dc.identifier.orcid0000-0002-9868-6914en
dc.identifier.orcid0000-0002-1102-8506en
dc.identifier.orcid0000-0002-9218-9917en
dc.identifier.orcid0000-0003-4864-7033en
dc.identifier.orcid0000-0002-6755-0221en
dc.identifier.orcid0000-0002-7046-8392en
dc.identifier.orcid0000-0002-8075-6275en
dc.identifier.pubmedid34233875-
local.name.researcherAnderson, Robin L
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
crisitem.author.deptMedical Oncology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
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