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dc.contributor.authorYanase, Fumitaka-
dc.contributor.authorNaorungroj, Thummaporn-
dc.contributor.authorBellomo, Rinaldo-
dc.identifier.citationBiomarkers 2020; 25(6): 425-435en
dc.description.abstractDespite wide interest in glycocalyx biomarkers, their values in healthy individuals, patients after abdominal surgery, and septic patients have been poorly understood. We searched MEDLINE, CENTRAL and EMBASE for papers measured glycocalyx biomarkers in healthy individuals, patients after abdominal surgery and septic patients. We extracted 3948 titles and identified 58 eligible papers. Syndecan 1 was the most frequently measured biomarker (48 studies). Its mean or median value in healthy individuals varied to a biologically implausible degree, from 0.3 to 58.5‚ÄČng/ml, according to assay manufacturer. In post-operative patients, syndecan 1 levels increased after pancreatic surgery or liver surgery, however, they showed minor changes after hysterectomy or laparoscopic surgery. In septic patients, biomarker levels were higher than in healthy volunteers when using the same assay. However, six healthy volunteer studies reported higher syndecan 1 values than after pancreatic surgery and 24 healthy volunteer studies reported higher syndecan 1 values than the lowest syndecan 1 value in sepsis. Similar findings applied to other glycocalyx biomarkers. Glycocalyx damage biomarkers values are essentially defined by syndecan 1. Syndecan 1 levels, however, are markedly affected by assay type and show biologically implausible values in normal, post-operative, or septic subjects.en
dc.subjectabdominal surgeryen
dc.subjecthealthy volunteeren
dc.subjectsyndecan 1en
dc.titleGlycocalyx damage biomarkers in healthy controls, abdominal surgery, and sepsis: a scoping review.en
dc.typeJournal Articleen
dc.identifier.affiliationDepartment of Intensive Care, Siriraj Hospital, Mahidol University, Bangkok, Thailanden
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Monash University School of Public Health and Preventive Medicine, Melbourne, Australiaen
dc.identifier.affiliationCentre for Integrated Critical Care, Department of Medicine and Radiology, University of Melbourne, Melbourne, Australiaen
dc.identifier.affiliationIntensive Careen
dc.identifier.pubmedid32597227, Rinaldo
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.cerifentitytypePublications- Care- Care- Care- Analytics Research and Evaluation (DARE) Centre-
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