Strategies for the Management of Solitary Pulmonary Nodules. A Survey of Patient Preferences.

Abstract

Guideline-based strategies for evaluation of solitary pulmonary nodules are tailored to the likelihood of malignancy. Surveillance, biopsy or resection are all reasonable approaches in fit individuals when the likelihood of malignancy is intermediate. Given the paucity of data demonstrating superior outcomes and important trade-offs between strategies, guidelines emphasize the importance of eliciting patient preferences and engaging in shared decision-making, however there is little literature on what patient preferences actually are. We conducted a cross-sectional, interview-administered questionnaire in 100 adults recruited from a metropolitan teaching hospital, using a hypothetical scenario designed to elicit patient preferences for different management strategies of solitary pulmonary nodules with probability of malignancy between 10% and 70%. The mean age of participants was 62 years (range 45 to 80), 56% were male, 94% were current or ex-smokers. Ninety-four percent completed all questions. At 10% probability of malignancy, 36.3% preferred surveillance, 42.4% preferred needle biopsy and 21.2% preferred surgical resection. Preference for surgical resection increased to 53.5% and 86.2% when the probability of malignancy was 30% and 70% respectively. Changes in the diagnostic yield of CT biopsy significantly altered preferences when probability of malignancy was 10% or 30%. The majority of participants surveyed expressed a preference for some type of biopsy over observation at all levels of solitary pulmonary nodule probability of malignancy evaluated. In an era of increasing solitary pulmonary nodule detection and patient-centered care, if confirmed in broader studies, these findings have considerable implications for processes of care and resource allocation.