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https://ahro.austin.org.au/austinjspui/handle/1/26597
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DC Field | Value | Language |
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dc.contributor.author | Khor, Yet H | - |
dc.contributor.author | Holland, Anne E | - |
dc.contributor.author | Goh, Nicole S L | - |
dc.contributor.author | Miller, Belinda R | - |
dc.contributor.author | Vlahos, Ross | - |
dc.contributor.author | Bozinovski, Steven | - |
dc.contributor.author | Lahham, Aroub | - |
dc.contributor.author | Glaspole, Ian | - |
dc.contributor.author | McDonald, Christine F | - |
dc.date | 2020-02-28 | - |
dc.date.accessioned | 2021-05-24T05:45:39Z | - |
dc.date.available | 2021-05-24T05:45:39Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.citation | Chest 2020; 158(1): 234-244 | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/26597 | - |
dc.description.abstract | Despite a lack of evidence, ambulatory oxygen therapy is frequently prescribed for patients with interstitial lung disease (ILD) and exertional desaturation. Patients often prefer portable oxygen concentrators to oxygen cylinders. This study aimed to examine the feasibility of conducting a clinical trial of ambulatory oxygen delivered via portable concentrators in patients with ILD. Is it feasible to conduct a clinical trial of ambulatory oxygen delivered via portable concentrators in patients with ILD? In this randomized, triple-blinded, sham-controlled trial, 30 participants with ILD and isolated exertional desaturation to < 90% on 6-minute walk tests were randomized to 12-week ambulatory oxygen or air delivered via portable concentrators, with assessments performed at baseline and weeks 4, 12, and 18. Primary outcomes were trial feasibility and the change in 6-minute walk distance (6MWD) on room air at week 12. Study recruitment was completed within 18 months, with six withdrawals. Participant blinding was successful, with the Bang's Blinding Index being 0 (95% CI, -0.40 to 0.40) for the oxygen group and 0 (95% CI, -0.42 to 0.42) for the sham group. No significant difference in 6MWD was seen between groups at week 12 (mean difference of -34 m [95% CI, -105 to 36], P = .34). For secondary outcomes, compared with the sham group, the oxygen group had a significantly higher Leicester Cough Questionnaire psychological domain score, indicating better cough-related quality of life (mean difference of 0.9 [95% CI, 0.2 to 1.6], P = .01), but a shorter duration of moderate-to-vigorous activities (mean difference of -135 [95% CI, -267 to -3], P = .04) at week 12. Based on the results of this pilot study, a definitive randomized controlled trial with a longer intervention duration is warranted to clarify therapeutic impacts of ambulatory oxygen in patients with ILD. Australian New Zealand Clinical Trials Registry; No.: ACTRN12617000054314; URL: www.anzctr.org.au/. | en |
dc.language.iso | eng | |
dc.subject | exertional hypoxemia | en |
dc.subject | idiopathic pulmonary fibrosis | en |
dc.subject | interstitial lung disease | en |
dc.subject | oxygen | en |
dc.subject | pulmonary fibrosis | en |
dc.title | Ambulatory Oxygen in Fibrotic Interstitial Lung Disease: A Pilot, Randomized, Triple-Blinded, Sham-Controlled Trial. | en |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | Chest | en |
dc.identifier.affiliation | School of Medicine, University of Melbourne, Melbourne, Victoria, Australia | en |
dc.identifier.affiliation | Department of Respiratory Medicine, Alfred Health, Melbourne, Victoria, Australia | en |
dc.identifier.affiliation | Department of Medicine, Monash University, Melbourne, Australia | en |
dc.identifier.affiliation | School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia | en |
dc.identifier.affiliation | Menzies Institute for Medical Research, University of Tasmania, Tasmania, Australia | en |
dc.identifier.affiliation | Institute for Breathing and Sleep | en |
dc.identifier.affiliation | Department of Physiotherapy, Alfred Health and Monash University, Melbourne, Australia | en |
dc.identifier.affiliation | Respiratory and Sleep Medicine | en |
dc.identifier.doi | 10.1016/j.chest.2020.01.049 | en |
dc.type.content | Text | en_US |
dc.identifier.pubmedid | 32113924 | |
local.name.researcher | Goh, Nicole S L | |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Respiratory and Sleep Medicine | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
crisitem.author.dept | Medicine (University of Melbourne) | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
crisitem.author.dept | Physiotherapy | - |
crisitem.author.dept | Respiratory and Sleep Medicine | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
crisitem.author.dept | Respiratory and Sleep Medicine | - |
Appears in Collections: | Journal articles |
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