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https://ahro.austin.org.au/austinjspui/handle/1/26428
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | McGauran, Monica Francesca Giannini | - |
dc.contributor.author | Pendlebury, Adam Bernard | - |
dc.contributor.author | Hiscock, Richard John | - |
dc.contributor.author | Lamont, Julie M | - |
dc.contributor.author | Jones, Antonia P M | - |
dc.contributor.author | Grant, Peter | - |
dc.contributor.author | Newman, Marsali R | - |
dc.contributor.author | Ireland-Jenkin, Kerryn | - |
dc.contributor.author | McGrath, Shaun | - |
dc.contributor.author | Pham, Kim | - |
dc.contributor.author | Hyde, Simon | - |
dc.date | 2021-05-03 | - |
dc.date.accessioned | 2021-05-10T07:13:24Z | - |
dc.date.available | 2021-05-10T07:13:24Z | - |
dc.date.issued | 2021-05-03 | - |
dc.identifier.citation | The Australian & New Zealand Journal of Obstetrics & Gynaecology 2021; 61(4): 569-575 | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/26428 | - |
dc.description.abstract | A renewed National Cervical Screening Program (NCSP) was introduced in Australia in December 2017. Under the renewed NCSP, there are limited data to guide the management of discordant colposcopy and biopsy results after a liquid-based cytology (LBC) finding of 'possible high-grade squamous intraepithelial lesion' (pHSIL). This study aims to determine the proportion of women referred with pHSIL who are found to have HSIL, identify influencing factors of women most at risk, and examine the role that cytopathology review plays in management decisions. Two-hundred and thirty-two women presenting to a tertiary women's hospital in Australia with pHSIL since December 2017 were identified. Women with HSIL following colposcopy directed biopsy were referred for treatment. When HSIL was not identified, these patients were referred for multidisciplinary clinicopathological review. Pathological outcomes and treatment recommendations are included. The primary outcome of the study was histological confirmation of HSIL. Primary outcome data were available for 182 women (78.5%); 62 (34.1%) had HSIL on histology, three (1.7%) had adenocarcinoma in situ (AIS) and one (1%) had cervical squamous cell carcinoma (SCC). There was no association between age and the presence of HSIL. The presence of human papillomavirus 16 and/or 18 increased the likelihood of HSIL on histology (relative risk 1.9; 95% CI 1.27-2.80, P = 0.002). Fifty-nine (25.4%) women were referred for observation who had low-grade squamous intraepithelial lesion/no dysplasia. Clinicopathological review optimises management and triage of patients with pHSIL on referral cytology. Understanding outcomes in these patients informs counselling and management. | en |
dc.language.iso | eng | - |
dc.subject | ASC-H atypical squamous cell | en |
dc.subject | HPV infection | en |
dc.subject | cervical intraepithelial neoplasm | en |
dc.subject | cervical smear | en |
dc.subject | pHSIL | en |
dc.title | Possible high-grade squamous intraepithelial lesion (pHSIL) in the new cervical screening paradigm: The outcomes and the role of clinicopathological review. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | The Australian & New Zealand Journal of Obstetrics & Gynaecology | en |
dc.identifier.affiliation | Department of Obstetrics & Gynaecology, The Mercy Hospital for Women, Melbourne, Victoria, Australia | en |
dc.identifier.affiliation | Department of Gynaecological Oncology, The Royal Women's Hospital, Melbourne, Victoria, Australia | en |
dc.identifier.affiliation | Department of Obstetrics & Gynaecology, The Northern Hospital, Melbourne, Victoria, Australia | en |
dc.identifier.affiliation | Anatomical Pathology | en |
dc.identifier.affiliation | Translational Obstetrics Group, Department of Obstetrics & Gynaecology, The Mercy Hospital for Women, University of Melbourne, Melbourne, Victoria, Australia | en |
dc.identifier.affiliation | Mercy Perinatal, The Mercy Hospital for Women, Melbourne, Victoria, Australia | en |
dc.identifier.affiliation | Department of Gynaecological Oncology, The Mercy Hospital for Women, Melbourne, Victoria, Australia | en |
dc.identifier.doi | 10.1111/ajo.13348 | en |
dc.type.content | Text | en |
dc.identifier.orcid | 0000-0002-2556-0755 | en |
dc.identifier.pubmedid | 33939180 | - |
local.name.researcher | Ireland-Jenkin, Kerryn | |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Anatomical Pathology | - |
Appears in Collections: | Journal articles |
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