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dc.contributor.authorFindakly, Salam-
dc.contributor.authorMaingard, Julian-
dc.contributor.authorPhan, Kevin-
dc.contributor.authorBarras, Christen D-
dc.contributor.authorJhamb, Ashu-
dc.contributor.authorChandra, Ronil-
dc.contributor.authorThijs, Vincent N-
dc.contributor.authorBrooks, Mark-
dc.contributor.authorAsadi, Hamed-
dc.identifier.citationInternal Medicine Journal 2020; 50(5): 530-541en
dc.description.abstractEndovascular clot retrieval (ECR) is the standard of care for acute ischaemic stroke due to large vessel occlusion. However, isolated occlusion of the M2 segment of the middle cerebral artery (MCA) was underrepresented in the landmark trials. Given the potential treatment benefit associated with M2 MCA occlusions, we aimed to evaluate the outcome of patients undergoing ECR for M2 occlusion. We conducted a systematic review and meta-analysis of the available literature that included patients with M2 MCA occlusions who underwent ECR. Successful reperfusion was defined as a treatment in cerebral ischaemia score of 2b-3. Good outcome was defined as a modified Rankin Scale score ≤ 2. We also analysed complications such as post-procedure symptomatic intracranial haemorrhage and mortality at 3 months. Fifteen studies including 1105 patients with isolated M2 occlusions were analysed. Successful reperfusion occurred in 75.4% (95% confidence interval (CI) 67.7-84.1%) of patients; good outcome was observed in 58.3% (95% CI 51.7-63.8% of patients. The rate of symptomatic intracranial haemorrhage was 5.1% (95% CI 4.2-8.3%), and 3-month mortality rate was 12.2% (95% CI 10.4-16.3%). The outcomes of ECR treatment of M2 occlusions are favourable, with good safety profile. Comparison to medical management from large registries or randomised controlled trials is warranted.en
dc.subjectendovascular clot retrievalen
dc.subjectischaemic Strokeen
dc.titleEndovascular clot retrieval for M2 segment middle cerebral artery occlusion: a systematic review and meta-analysis.en
dc.typeJournal Articleen_US
dc.identifier.journaltitleInternal Medicine Journalen
dc.identifier.affiliationSchool of Medicine, Deakin University, Geelong, Victoria, Australiaen
dc.identifier.affiliationThe University of Adelaide, Adelaide, South Australia, Australiaen
dc.identifier.affiliationStroke Division, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationMonash Health, Melbourne, Victoria, Australiaen
dc.identifier.affiliationNeuroSpine Surgery Research Group, Prince of Wales Private Hospital, Sydney, New South Wales, Australiaen
dc.identifier.affiliationInterventional Neuroradiology Unit, Monash Imaging, Monash Health, Melbourne, Victoria, Australiaen
dc.identifier.affiliationSouth Australian Health and Medical Research Institute, Adelaide, South Australia, Australiaen
dc.identifier.affiliationDepartment of Imaging, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationThe University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.pubmedid31059208, Hamed
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristype Florey Institute of Neuroscience and Mental Health-
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