Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/26252
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dc.contributor.authorThakur, Sameer-
dc.contributor.authorFlorisson, Daniel-
dc.contributor.authorTelianidis, Stacy-
dc.contributor.authorYaftian, Nima-
dc.contributor.authorLee, Jean-
dc.contributor.authorKnight, Simon R-
dc.contributor.authorBarnett, Stephen A-
dc.contributor.authorSeevanayagam, Siven-
dc.contributor.authorAntippa, Phillip-
dc.contributor.authorAlam, Naveed-
dc.contributor.authorWright, Gavin-
dc.date2020-04-14-
dc.date.accessioned2021-04-19T05:58:49Z-
dc.date.available2021-04-19T05:58:49Z-
dc.date.issued2021-07-
dc.identifier.citationAsian Cardiovascular & Thoracic Annals 2021; 29(6): 532-540en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/26252-
dc.description.abstractPulmonary carcinoids are rare neoplasms, accounting for approximately 1%-2% of all lung malignancies. A retrospective analysis was undertaken of all patients who underwent surgical resection of pulmonary carcinoid tumours across multiple institutions in Melbourne, Australia. From May 2000 through April 2020, 241 patients who underwent surgical resection of pulmonary carcinoid tumours were retrospectively reviewed. Patient demographics, pathologic data, and long-term outcomes were recorded. Median age was 57.7 years and the majority of patients were female (58.9% vs. 41.1%). Typical carcinoid was present in 77.1%. Histological subtype was associated with several factors. Atypical carcinoid was more likely to have larger tumour size and nodal involvement. Overall survival for typical carcinoid at 5, 10, and 15 years was 98%, 95%, and 84%, and for atypical carcinoid was 88%, 82%, and 62%, respectively. Histological subtype and age were found to be independent predictors of overall survival, with worse outcomes for atypical and those above 60 years of age. Disease-free survival was related to sublobar resection (p < 0.001, sub-hazard ratio (SHR): 6.89), lymph node involvement (p = 0.022, SHR: 3.18), and atypical histology (p < 0.001, SHR: 9.89). Excellent long-term outcomes can be achieved following surgical resection of pulmonary carcinoids. Atypical histology and lymph node involvement are significant prognostic factors, and sublobar resection should not be considered in patients with either of the above features. Typical carcinoid tumour without nodal involvement may be appropriate for sublobar resection. Typical and atypical carcinoid tumours should be considered distinct disease entities, and as such treated accordingly.en
dc.language.isoeng
dc.subjectThoracic surgeryen
dc.subjectlung canceren
dc.subjectneuroendocrine tumoursen
dc.subjectoncologyen
dc.subjectpulmonary carcinoiden
dc.titlePulmonary carcinoid tumours: A multi-centre analysis of survival and predictors of outcome following sublobar, lobar, and extended pulmonary resections.en
dc.typeJournal Articleen
dc.identifier.journaltitleAsian Cardiovascular & Thoracic Annalsen
dc.identifier.affiliationDepartment of Medical Imaging, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australiaen
dc.identifier.affiliationDepartment of Cardiothoracic Surgery, Royal Melbourne Hospital, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDivision of Cancer Surgery, Peter McCallum Cancer Centre, Parkville, Victoria, Australiaen
dc.identifier.affiliationThoracic Surgeryen
dc.identifier.affiliationDepartment of Cardiothoracic Surgery, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australiaen
dc.identifier.doi10.1177/02184923211010090en
dc.type.contentTexten
dc.identifier.orcid0000-0002-8206-0319en
dc.identifier.pubmedid33853389
local.name.researcherBarnett, Stephen A
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
crisitem.author.deptThoracic Surgery-
crisitem.author.deptThoracic Surgery-
crisitem.author.deptEndocrinology-
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