Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/26214
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLee, Sze Ting-
dc.contributor.authorTebbutt, Niall C-
dc.contributor.authorGan, Hui K-
dc.contributor.authorLiu, Zhanqi-
dc.contributor.authorSachinidis, John-
dc.contributor.authorPathmaraj, Kunthi-
dc.contributor.authorScott, Andrew M-
dc.date2021-03-17-
dc.date.accessioned2021-04-12T05:42:47Z-
dc.date.available2021-04-12T05:42:47Z-
dc.date.issued2021-03-17-
dc.identifier.citationFrontiers in Oncology 2021; 11: 606210en
dc.identifier.issn2234-943X
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/26214-
dc.description.abstractTumor hypoxia and angiogenesis are implicated in tumor growth and metastases, and anti-angiogenic therapies have an important role in treating patients with metastatic colorectal cancer. However, the prevalence of hypoxia has not been fully evaluated in colorectal liver metastases, and hypoxic response to anti-angiogenic therapy has not been clearly established. The aims of the study were to evaluate the changes seen on 18F-FMISO and 18F-FDG PET scans in patients treated with anti-angiogenic therapy, and to correlate these measures of hypoxia and metabolism with clinical outcomes, and blood biomarkers of angiogenesis. Patients with metastatic colorectal carcinoma planned for treatment with bevacizumab and chemotherapy received routine staging investigations prior to any treatment, including a FDG PET scan. A FMISO PET scan was performed within 4 weeks of staging tests, with blood specimens collected at that time for serum VEGF and osteopontin measurement. Follow-up FDG and FMISO scans were performed after 1 cycle of treatment. Results were compared to response (RECIST), progression free survival (PFS), and overall survival (OS). A total of 15 patients were recruited into this prospective trial, of which 13 patients were evaluable for assessment of treatment follow-up. Baseline FDG uptake was higher than FMISO uptake, and there was a significant decrease in FDG uptake (SUVmax and TGV) but not FMISO uptake (SUVmax and TNR) after treatment. There was a positive correlation between FDG and FMISO SUVmax on both baseline and post-treatment PET scans. Blood biomarkers of serum VEGF and osteopontin were significantly correlated with the FDG and FMISO PET parameters. This study shows that hypoxia in metastatic colorectal cancer, assessed by FMISO PET, shows minor changes following initial treatment with anti-angiogenic therapy, but is associated with therapeutic response. FDG PET uptake changes (SUVmax, TLG) are also associated with response to anti-angiogenic therapy. These findings demonstrate the interplay between tumor metabolism and hypoxic regulation following anti-angiogenic treatment of metastatic colorectal cancer.en
dc.language.isoeng
dc.subjectangiogenesisen
dc.subjectbevacizumaben
dc.subjectfluoromisonidazole (FMISO) positron emission tomography (PET)en
dc.subjecthypoxiaen
dc.subjectmetastatic colorectal carcinomaen
dc.subjectresponseen
dc.titleEvaluation of 18F-FMISO PET and 18F-FDG PET Scans in Assessing the Therapeutic Response of Patients With Metastatic Colorectal Cancer Treated With Anti-Angiogenic Therapy.en
dc.typeJournal Articleen
dc.identifier.journaltitleFrontiers in Oncologyen
dc.identifier.affiliationMedical Oncologyen
dc.identifier.affiliationSurgery (University of Melbourne)en
dc.identifier.affiliationMedicine (University of Melbourne)en
dc.identifier.affiliationMolecular Imaging and Therapyen
dc.identifier.affiliationOlivia Newton-John Cancer Research Instituteen
dc.identifier.affiliationSchool of Cancer Medicine, La Trobe University, Melbourne, VIC, Australiaen
dc.identifier.doi10.3389/fonc.2021.606210en
dc.type.contentTexten
dc.identifier.pubmedid33816239
local.name.researcherGan, Hui K
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMedical Oncology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
crisitem.author.deptMedical Oncology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

28
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.